CR20120542A - HETEROARIL-CICLOHEXIL-TETRAAZABENZO [e] AZULENOS - Google Patents

HETEROARIL-CICLOHEXIL-TETRAAZABENZO [e] AZULENOS

Info

Publication number
CR20120542A
CR20120542A CR20120542A CR20120542A CR20120542A CR 20120542 A CR20120542 A CR 20120542A CR 20120542 A CR20120542 A CR 20120542A CR 20120542 A CR20120542 A CR 20120542A CR 20120542 A CR20120542 A CR 20120542A
Authority
CR
Costa Rica
Prior art keywords
tetraazabenzo
azulenos
ciclohexil
heteroaril
receptor
Prior art date
Application number
CR20120542A
Other languages
English (en)
Inventor
Cosimo Dolente
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20120542A publication Critical patent/CR20120542A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a heteroaril-ciclo-hexil-tetraazabenzo [e] azulenos de la fórmula I en la que R1, R2 y R3 tienen los significados aquí descritos. Los compuestos de la invención actúan como moduladores del receptor de la V1a y en particular como antagonistas del receptor de la V1a; la invención se refiere también a su obtención, a composiciones farmacéuticas que los contienen y a su utilización como medicamentos.
CR20120542A 2010-05-10 2012-10-23 HETEROARIL-CICLOHEXIL-TETRAAZABENZO [e] AZULENOS CR20120542A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10162451 2010-05-10

Publications (1)

Publication Number Publication Date
CR20120542A true CR20120542A (es) 2013-01-11

Family

ID=44080459

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120542A CR20120542A (es) 2010-05-10 2012-10-23 HETEROARIL-CICLOHEXIL-TETRAAZABENZO [e] AZULENOS

Country Status (34)

Country Link
US (1) US8513238B2 (es)
EP (1) EP2569319B1 (es)
JP (1) JP5868959B2 (es)
KR (1) KR20130109958A (es)
CN (1) CN102884065B (es)
AR (1) AR081374A1 (es)
AU (1) AU2011252116B2 (es)
BR (1) BR112012028763A2 (es)
CA (1) CA2797920A1 (es)
CL (1) CL2012003132A1 (es)
CO (1) CO6620058A2 (es)
CR (1) CR20120542A (es)
CY (1) CY1115820T1 (es)
DK (1) DK2569319T3 (es)
EA (1) EA021441B1 (es)
EC (1) ECSP12012291A (es)
ES (1) ES2523881T3 (es)
HK (1) HK1176934A1 (es)
HR (1) HRP20141250T1 (es)
IL (1) IL222815A (es)
MA (1) MA34252B1 (es)
MX (1) MX2012012857A (es)
MY (1) MY160517A (es)
NZ (1) NZ603223A (es)
PE (1) PE20130401A1 (es)
PL (1) PL2569319T3 (es)
PT (1) PT2569319E (es)
RS (1) RS53669B1 (es)
SG (1) SG185484A1 (es)
SI (1) SI2569319T1 (es)
TW (1) TWI419892B (es)
UA (1) UA110616C2 (es)
WO (1) WO2011141396A1 (es)
ZA (1) ZA201208317B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2356123E (pt) 2008-11-13 2012-10-31 Hoffmann La Roche Espiro-5,6-di-hidro-4h-2,3,5,10b-tetra-azabenzo[ e]azulenos
CN102216304B (zh) 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
SG171846A1 (en) 2008-11-28 2011-07-28 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
EP3568392B1 (de) 2017-01-10 2021-02-24 Bayer Aktiengesellschaft Imidazol-derivate als schädlingsbekämpfungsmittel
KR20230020566A (ko) 2017-01-10 2023-02-10 바이엘 악티엔게젤샤프트 해충 방제제로서의 헤테로사이클 유도체
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
CN113544125A (zh) 2019-03-08 2021-10-22 先正达农作物保护股份公司 杀有害生物活性的唑-酰胺化合物
ES2972949T3 (es) 2019-03-20 2024-06-17 Syngenta Crop Protection Ag Compuestos de azolamida plaguicidamente activos
WO2022135335A1 (zh) * 2020-12-21 2022-06-30 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428157A (en) 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
NL9401174A (nl) 1994-07-15 1996-02-01 A P I S Medical Bv Inspuitsamenstel met opzuignaald en terugtrekbare inspuitnaald.
BR9811585A (pt) * 1997-07-30 2000-09-26 American Home Prod Agonistas de vasopressinas tricìclicas
PT1147115E (pt) 1999-01-19 2004-02-27 Ortho Mcneil Pharm Inc Benzodiazepinas triciclicas como antagonistas do receptor da vasopressina
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US6852730B2 (en) 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
GB0303852D0 (en) 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
GB0400700D0 (en) 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
KR100840852B1 (ko) 2004-05-25 2008-06-23 화이자 프로덕츠 인크. 테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체
EP1753766A1 (en) 2004-05-25 2007-02-21 Pfizer Products Inc. Tetraazabenzo(e)azulene derivatives and analogs thereof
EP1632494A1 (en) 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
WO2006021882A1 (en) 2004-08-25 2006-03-02 Pfizer Limited Triazolobenzodiazepines and their use as vasopressin antagonists
ES2355923T3 (es) * 2004-08-26 2011-04-01 Pfizer, Inc. Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
US20080188478A1 (en) 2005-04-26 2008-08-07 Pfizer Inc. Compounds Useful In Therapy
WO2006123242A1 (en) 2005-05-18 2006-11-23 Pfizer Limited 1, 2, 4 -triazole derivatives as vasopressin antagonists
AU2008204491B2 (en) 2007-01-12 2012-05-03 F. Hoffmann-La Roche Ag Spiropiperidine glycinamide derivatives
CN102216304B (zh) 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes

Also Published As

Publication number Publication date
JP2013526500A (ja) 2013-06-24
EA021441B1 (ru) 2015-06-30
CN102884065A (zh) 2013-01-16
JP5868959B2 (ja) 2016-02-24
ES2523881T3 (es) 2014-12-02
CA2797920A1 (en) 2011-11-17
CY1115820T1 (el) 2017-01-25
AR081374A1 (es) 2012-08-29
EA201291187A1 (ru) 2013-04-30
UA110616C2 (uk) 2016-01-25
MA34252B1 (fr) 2013-05-02
CL2012003132A1 (es) 2013-06-28
US20110275801A1 (en) 2011-11-10
SI2569319T1 (sl) 2014-12-31
SG185484A1 (en) 2012-12-28
RS53669B1 (en) 2015-04-30
PE20130401A1 (es) 2013-04-10
HK1176934A1 (zh) 2013-08-09
KR20130109958A (ko) 2013-10-08
HRP20141250T1 (en) 2015-03-13
US8513238B2 (en) 2013-08-20
AU2011252116B2 (en) 2014-03-13
MX2012012857A (es) 2012-11-29
BR112012028763A2 (pt) 2016-07-19
ECSP12012291A (es) 2012-12-28
TWI419892B (zh) 2013-12-21
AU2011252116A1 (en) 2012-11-22
PL2569319T3 (pl) 2015-03-31
DK2569319T3 (da) 2014-10-20
ZA201208317B (en) 2014-04-30
TW201200520A (en) 2012-01-01
WO2011141396A1 (en) 2011-11-17
EP2569319B1 (en) 2014-09-24
PT2569319E (pt) 2014-11-24
CO6620058A2 (es) 2013-02-15
EP2569319A1 (en) 2013-03-20
NZ603223A (en) 2014-09-26
CN102884065B (zh) 2015-11-25
MY160517A (en) 2017-03-15
IL222815A (en) 2014-08-31

Similar Documents

Publication Publication Date Title
CR20120542A (es) HETEROARIL-CICLOHEXIL-TETRAAZABENZO [e] AZULENOS
BR112015012555A2 (pt) derivados de benzimidazol como antagonistas de ep4
EA201401351A1 (ru) Производные бензимидазол-пролина
CR20130671A (es) Antagonistas de trpv4
GT201300196A (es) Moduladores del receptor de glucagón
ECSP11011517A (es) Compuestos antivirales
GT201200307A (es) NUEVOS DERIVADOS DE CICLOHEXILAMINA QUE TIENEN ACTIVIDAD COMO AGONISTAS ADRENÉRGICOS ß2 Y COMO ANTAGONISTAS MUSCARÍNICOS M3
DOP2014000115A (es) Uso de 4-fenil-piridinas sustituidas para la fabricación de medicamentos útiles en el tratamiento de enfermedades relacionadas con el receptor de nk1
ECSP14008606A (es) Nuevos derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
BR112015001613A8 (pt) Compostos que são agentes de modulação de s1p e/ou agentes de modulação de atx, seus usos e composição farmacêutica
CO6480918A2 (es) Antagonistas policíclicos de receptores de ácido lisofosfatídico.
UY33078A (es) Derivados de imidazoquinolina
ECSP14013327A (es) Compuestos con actividad nematicida
CR20130239A (es) Compuestos de triazolopiridina
CR20150204A (es) Nuevos derivados de piridina
UY33871A (es) Compuestos y formulaciones farmacéuticas basadas en derivados de benzo y heteroarilos condensados 2,3-dihidrofurán-2-il-piperidina y sus usos
DOP2011000382A (es) Sulfonamidas heterociclicas, usos y composiciones farmaceuticas de las mismas
NI201500080A (es) Nuevos derivados carbamato de ciclohexilo y quinuclidinilo que tienen actividad como agonistas b2 adrenérgicos y como antagonistas muscarínicos m3.
CR20150322A (es) Nuevos derivados carbamato de ciclohexilo y quinuclidinilo que tienen actividad como agonistas b2 adrenérgicos y como antagonistas muscarínicos m3
ECSP13012838A (es) Nuevos compuestos de benzodioxol-piperazina
CO6351723A2 (es) Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1
GEP20186911B (en) Substituted chroman compounds as calcium sensing receptor modulators
UY32520A (es) Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
TR201903918T4 (tr) Bir dağıtım ajanı içeren bileşimler ve bunların hazırlanması.
EA201501163A1 (ru) Модуляторы рецептора cxcr7