CO6351723A2 - Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 - Google Patents

Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1

Info

Publication number
CO6351723A2
CO6351723A2 CO11011419A CO11011419A CO6351723A2 CO 6351723 A2 CO6351723 A2 CO 6351723A2 CO 11011419 A CO11011419 A CO 11011419A CO 11011419 A CO11011419 A CO 11011419A CO 6351723 A2 CO6351723 A2 CO 6351723A2
Authority
CO
Colombia
Prior art keywords
crf1
derivatives
antigonist
pirazolo
oxazol
Prior art date
Application number
CO11011419A
Other languages
English (en)
Inventor
Ian Bruce
Andrew James Culshaw
Nicholas James Devereux
Francois Gessier
Jeffrey Mckenna
James Neef
Helen Elizabeth Oakman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6351723A2 publication Critical patent/CO6351723A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
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Abstract

La presente invención se refiere a derivados de pirazolo-(5.1-b}- oxazol, a su preparación, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que los contienen. Más particularmente, la presente invención se refiere a su uso como antagonistas del receptor del factor de liberación de corticotropina (CRF1). Un compuesto de a fórmula I:
CO11011419A 2008-08-06 2011-02-01 Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 CO6351723A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161930 2008-08-06
US20509609P 2009-01-14 2009-01-14
EP09150553 2009-01-14

Publications (1)

Publication Number Publication Date
CO6351723A2 true CO6351723A2 (es) 2011-12-20

Family

ID=41653505

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11011419A CO6351723A2 (es) 2008-08-06 2011-02-01 Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1

Country Status (18)

Country Link
US (1) US7994203B2 (es)
EP (1) EP2328902A1 (es)
JP (1) JP2011529943A (es)
KR (1) KR20110051226A (es)
CN (1) CN102171220A (es)
AR (1) AR073262A1 (es)
AU (1) AU2009279137A1 (es)
BR (1) BRPI0917565A2 (es)
CA (1) CA2733176A1 (es)
CO (1) CO6351723A2 (es)
EA (1) EA201100303A1 (es)
EC (1) ECSP11010801A (es)
IL (1) IL211030A0 (es)
MA (1) MA32537B1 (es)
MX (1) MX2011001392A (es)
TW (1) TW201011039A (es)
UY (1) UY32029A (es)
WO (1) WO2010015628A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ588376A (en) 2008-04-15 2011-06-30 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound having antagonism against corticotropin-releasing factor (CRF) receptor
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
JPWO2011043387A1 (ja) 2009-10-08 2013-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
WO2011092290A1 (en) * 2010-02-01 2011-08-04 Novartis Ag Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8546416B2 (en) 2011-05-27 2013-10-01 Novartis Ag 3-spirocyclic piperidine derivatives as ghrelin receptor agonists
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2867043A1 (en) 2012-05-03 2013-11-07 Novartis Ag L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists
BR112016016975B1 (pt) 2014-01-21 2022-12-27 Neurocrine Biosciences Inc Usos de um antagonista do receptor crf1 para o tratamento de hiperplasia adrenal congênita e para reduzir níveis de 17-ohp e acth em um paciente
US11878001B2 (en) 2017-07-31 2024-01-23 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5426296A (en) * 1995-04-04 1996-10-23 E.I. Du Pont De Nemours And Company Herbicidal heteroaryl-substituted anilides
JP2004531475A (ja) * 2001-01-26 2004-10-14 ブリストル−マイヤーズ　スクイブ　カンパニー コルチコトロピン放出因子阻害剤としてのイミダゾリル誘導体

Also Published As

Publication number Publication date
CN102171220A (zh) 2011-08-31
TW201011039A (en) 2010-03-16
EA201100303A1 (ru) 2011-10-31
US7994203B2 (en) 2011-08-09
CA2733176A1 (en) 2010-02-11
KR20110051226A (ko) 2011-05-17
EP2328902A1 (en) 2011-06-08
AU2009279137A8 (en) 2011-03-03
UY32029A (es) 2010-03-26
JP2011529943A (ja) 2011-12-15
US20100035874A1 (en) 2010-02-11
BRPI0917565A2 (pt) 2015-11-17
MA32537B1 (fr) 2011-08-01
IL211030A0 (en) 2011-04-28
AU2009279137A1 (en) 2010-02-11
ECSP11010801A (es) 2011-03-31
AR073262A1 (es) 2010-10-28
WO2010015628A1 (en) 2010-02-11
MX2011001392A (es) 2011-03-25

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