CL2012003132A1 - Compuestos derivados de heteroaril-ciclohexil-tetraazabenzo[e]azulenos, antagonistas del receptor de la vla; proceso de preparacion; composicion farmaceutica; y su uso para la prevencion o tratamiento de dismenorrea, disfuncion sexual masculina o femenina, hipertension y cirrosis hepatica, entre otros. - Google Patents
Compuestos derivados de heteroaril-ciclohexil-tetraazabenzo[e]azulenos, antagonistas del receptor de la vla; proceso de preparacion; composicion farmaceutica; y su uso para la prevencion o tratamiento de dismenorrea, disfuncion sexual masculina o femenina, hipertension y cirrosis hepatica, entre otros.Info
- Publication number
- CL2012003132A1 CL2012003132A1 CL2012003132A CL2012003132A CL2012003132A1 CL 2012003132 A1 CL2012003132 A1 CL 2012003132A1 CL 2012003132 A CL2012003132 A CL 2012003132A CL 2012003132 A CL2012003132 A CL 2012003132A CL 2012003132 A1 CL2012003132 A1 CL 2012003132A1
- Authority
- CL
- Chile
- Prior art keywords
- tetraazabenzo
- dysmenorrhea
- treatment
- hypertension
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Compuestos derivados de heteroaril-ciclohexil-tetraazabenzo[e]azulenos, antagonistas del receptor de la vía; proceso para obtenerlos; composición farmacéutica; método de tratamiento; y su uso para la prevención o el tratamiento de dismenorrea, disfunción sexual masculina o femenina, hipertensión y cirrosis hepática, entre otros.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10162451 | 2010-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012003132A1 true CL2012003132A1 (es) | 2013-06-28 |
Family
ID=44080459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012003132A CL2012003132A1 (es) | 2010-05-10 | 2012-11-08 | Compuestos derivados de heteroaril-ciclohexil-tetraazabenzo[e]azulenos, antagonistas del receptor de la vla; proceso de preparacion; composicion farmaceutica; y su uso para la prevencion o tratamiento de dismenorrea, disfuncion sexual masculina o femenina, hipertension y cirrosis hepatica, entre otros. |
Country Status (34)
Country | Link |
---|---|
US (1) | US8513238B2 (es) |
EP (1) | EP2569319B1 (es) |
JP (1) | JP5868959B2 (es) |
KR (1) | KR20130109958A (es) |
CN (1) | CN102884065B (es) |
AR (1) | AR081374A1 (es) |
AU (1) | AU2011252116B2 (es) |
BR (1) | BR112012028763A2 (es) |
CA (1) | CA2797920A1 (es) |
CL (1) | CL2012003132A1 (es) |
CO (1) | CO6620058A2 (es) |
CR (1) | CR20120542A (es) |
CY (1) | CY1115820T1 (es) |
DK (1) | DK2569319T3 (es) |
EA (1) | EA021441B1 (es) |
EC (1) | ECSP12012291A (es) |
ES (1) | ES2523881T3 (es) |
HK (1) | HK1176934A1 (es) |
HR (1) | HRP20141250T1 (es) |
IL (1) | IL222815A (es) |
MA (1) | MA34252B1 (es) |
MX (1) | MX2012012857A (es) |
MY (1) | MY160517A (es) |
NZ (1) | NZ603223A (es) |
PE (1) | PE20130401A1 (es) |
PL (1) | PL2569319T3 (es) |
PT (1) | PT2569319E (es) |
RS (1) | RS53669B1 (es) |
SG (1) | SG185484A1 (es) |
SI (1) | SI2569319T1 (es) |
TW (1) | TWI419892B (es) |
UA (1) | UA110616C2 (es) |
WO (1) | WO2011141396A1 (es) |
ZA (1) | ZA201208317B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0921110A2 (pt) | 2008-11-13 | 2016-02-16 | Hoffmann La Roche | espiro-5,6-di-hidro-4h-2,3,5,10b-tetraaza-benzo[e]azulenos |
WO2010057795A1 (en) | 2008-11-18 | 2010-05-27 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
ES2431279T3 (es) | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
WO2017191117A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | V1a receptor antagonists for use in the treatment of renal diseases |
CN110382485B (zh) | 2017-01-10 | 2022-05-10 | 拜耳公司 | 作为害虫防治剂的杂环烯衍生物 |
KR102628073B1 (ko) | 2017-01-10 | 2024-01-22 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 헤테로사이클 유도체 |
TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
US20220167618A1 (en) | 2019-03-08 | 2022-06-02 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
WO2020188014A1 (en) | 2019-03-20 | 2020-09-24 | Syngenta Crop Protection Ag | Pesticidally active azole amide compounds |
TWI804119B (zh) * | 2020-12-21 | 2023-06-01 | 大陸商上海濟煜醫藥科技有限公司 | 三氮唑類三并環衍生物及其製備方法和應用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5428157A (en) | 1993-11-22 | 1995-06-27 | Merck & Co., Inc. | 3-acylaminobenzodiazepines |
NL9401174A (nl) | 1994-07-15 | 1996-02-01 | A P I S Medical Bv | Inspuitsamenstel met opzuignaald en terugtrekbare inspuitnaald. |
NZ502449A (en) * | 1997-07-30 | 2002-08-28 | Wyeth Corp | Tricyclic vasopressin agonists and their pharmaceutical use |
EP1147115B3 (en) | 1999-01-19 | 2008-12-24 | Ortho-McNeil Pharmaceutical, Inc. | Tricyclic benzodiazepines as vasopressin receptor antagonists |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
US6852730B2 (en) | 2002-02-07 | 2005-02-08 | Neurogen Corporation | Substituted fused pyrazolecarboxylic acid arylamides and related compounds |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
CA2568056A1 (en) | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Tetraazabenzo[e]azulene derivatives and analogs thereof |
KR100840852B1 (ko) | 2004-05-25 | 2008-06-23 | 화이자 프로덕츠 인크. | 테트라아자벤조[e]아줄렌 유도체 및 이의 유사체 |
EP1632494A1 (en) | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
JP2008510789A (ja) | 2004-08-25 | 2008-04-10 | ファイザー・インク | トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 |
AU2005276132B2 (en) * | 2004-08-26 | 2011-09-29 | Pfizer Inc. | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
US20080188478A1 (en) | 2005-04-26 | 2008-08-07 | Pfizer Inc. | Compounds Useful In Therapy |
US20080234252A1 (en) | 2005-05-18 | 2008-09-25 | Pfizer Inc | Compounds Useful in Therapy |
ES2376378T3 (es) | 2007-01-12 | 2012-03-13 | F. Hoffmann-La Roche Ag | Derivados de espiropiperidina-glicinamida. |
WO2010057795A1 (en) | 2008-11-18 | 2010-05-27 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
-
2011
- 2011-05-05 US US13/101,173 patent/US8513238B2/en active Active
- 2011-05-09 KR KR1020127032241A patent/KR20130109958A/ko not_active Application Discontinuation
- 2011-05-09 NZ NZ603223A patent/NZ603223A/en not_active IP Right Cessation
- 2011-05-09 MY MYPI2012004887A patent/MY160517A/en unknown
- 2011-05-09 WO PCT/EP2011/057368 patent/WO2011141396A1/en active Application Filing
- 2011-05-09 DK DK11718393.9T patent/DK2569319T3/da active
- 2011-05-09 AR ARP110101587A patent/AR081374A1/es unknown
- 2011-05-09 SG SG2012082483A patent/SG185484A1/en unknown
- 2011-05-09 EA EA201291187A patent/EA021441B1/ru not_active IP Right Cessation
- 2011-05-09 AU AU2011252116A patent/AU2011252116B2/en not_active Ceased
- 2011-05-09 SI SI201130313T patent/SI2569319T1/sl unknown
- 2011-05-09 CN CN201180023289.3A patent/CN102884065B/zh not_active Expired - Fee Related
- 2011-05-09 JP JP2013509524A patent/JP5868959B2/ja active Active
- 2011-05-09 CA CA2797920A patent/CA2797920A1/en not_active Abandoned
- 2011-05-09 PE PE2012002147A patent/PE20130401A1/es not_active Application Discontinuation
- 2011-05-09 MX MX2012012857A patent/MX2012012857A/es active IP Right Grant
- 2011-05-09 PL PL11718393T patent/PL2569319T3/pl unknown
- 2011-05-09 MA MA35399A patent/MA34252B1/fr unknown
- 2011-05-09 TW TW100116207A patent/TWI419892B/zh not_active IP Right Cessation
- 2011-05-09 ES ES11718393.9T patent/ES2523881T3/es active Active
- 2011-05-09 RS RS20140639A patent/RS53669B1/en unknown
- 2011-05-09 EP EP11718393.9A patent/EP2569319B1/en active Active
- 2011-05-09 BR BR112012028763A patent/BR112012028763A2/pt not_active IP Right Cessation
- 2011-05-09 PT PT117183939T patent/PT2569319E/pt unknown
- 2011-09-05 UA UAA201213888A patent/UA110616C2/uk unknown
-
2012
- 2012-10-23 CR CR20120542A patent/CR20120542A/es unknown
- 2012-10-25 CO CO12191162A patent/CO6620058A2/es active IP Right Grant
- 2012-11-01 IL IL222815A patent/IL222815A/en active IP Right Grant
- 2012-11-05 ZA ZA2012/08317A patent/ZA201208317B/en unknown
- 2012-11-08 CL CL2012003132A patent/CL2012003132A1/es unknown
- 2012-11-09 EC ECSP12012291 patent/ECSP12012291A/es unknown
-
2013
- 2013-04-12 HK HK13104456.4A patent/HK1176934A1/zh not_active IP Right Cessation
-
2014
- 2014-12-16 CY CY20141101044T patent/CY1115820T1/el unknown
- 2014-12-22 HR HRP20141250AT patent/HRP20141250T1/hr unknown
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