CU24000B1 - Un derivado 2-carboxamida-cicloamino-urea-tiazol-piridilo - Google Patents

Un derivado 2-carboxamida-cicloamino-urea-tiazol-piridilo

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Publication number
CU24000B1
CU24000B1 CU2011000052A CU20110052A CU24000B1 CU 24000 B1 CU24000 B1 CU 24000B1 CU 2011000052 A CU2011000052 A CU 2011000052A CU 20110052 A CU20110052 A CU 20110052A CU 24000 B1 CU24000 B1 CU 24000B1
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CU
Cuba
Prior art keywords
cicloamino
piridilo
carboxamida
tiazol
urea
Prior art date
Application number
CU2011000052A
Other languages
English (en)
Other versions
CU20110052A7 (es
Inventor
Giorgio Caravatti
Robin Alec Fairhurst
Pascal Furet
Vito Guagnano
Patricia Imbach
Original Assignee
Novartis Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40350060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24000(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20110052A7 publication Critical patent/CU20110052A7/es
Publication of CU24000B1 publication Critical patent/CU24000B1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente invención se refiere al compuesto (S)-1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il}-amida de 2-amida del ácido pirrolidin-1,2-dicarboxílico de la fórmula I: útil en el tratamiento de enfermedades que mejoran mediante la inhibición de la cinasa de fosfatidil-inositol-3.
CU2011000052A 2008-09-10 2011-03-10 Un derivado 2-carboxamida-cicloamino-urea-tiazol-piridilo CU24000B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08164104 2008-09-10
US9667408P 2008-09-12 2008-09-12
PCT/EP2009/061644 WO2010029082A1 (en) 2008-09-10 2009-09-08 Organic compounds

Publications (2)

Publication Number Publication Date
CU20110052A7 CU20110052A7 (es) 2011-12-28
CU24000B1 true CU24000B1 (es) 2014-06-27

Family

ID=40350060

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2011000052A CU24000B1 (es) 2008-09-10 2011-03-10 Un derivado 2-carboxamida-cicloamino-urea-tiazol-piridilo

Country Status (50)

Country Link
US (4) US8227462B2 (es)
EP (1) EP2331537B1 (es)
JP (1) JP5486601B2 (es)
KR (1) KR101290844B1 (es)
CN (1) CN102149711B (es)
AR (2) AR073369A1 (es)
AU (1) AU2009290904B2 (es)
BR (1) BRPI0918750B8 (es)
CA (1) CA2734819C (es)
CL (1) CL2011000504A1 (es)
CO (1) CO6351738A2 (es)
CR (1) CR20110059A (es)
CU (1) CU24000B1 (es)
CY (2) CY1117078T1 (es)
DK (1) DK2331537T3 (es)
DO (1) DOP2011000070A (es)
EA (1) EA018863B1 (es)
EC (1) ECSP11010880A (es)
ES (1) ES2560673T3 (es)
GE (1) GEP20135991B (es)
HK (1) HK1156305A1 (es)
HN (1) HN2011000699A (es)
HR (1) HRP20160014T1 (es)
HU (2) HUE025884T2 (es)
IL (1) IL210976A (es)
JO (1) JO3121B1 (es)
LT (1) LTC2331537I2 (es)
LU (1) LUC00186I2 (es)
MA (1) MA32604B1 (es)
ME (1) ME01284B (es)
MX (1) MX2011002597A (es)
MY (1) MY151556A (es)
NI (1) NI201100049A (es)
NL (1) NL301071I2 (es)
NO (1) NO2020037I1 (es)
NZ (1) NZ590754A (es)
PA (1) PA8841901A1 (es)
PE (1) PE20110796A1 (es)
PL (1) PL2331537T3 (es)
PT (1) PT2331537E (es)
RS (1) RS54476B1 (es)
SI (1) SI2331537T1 (es)
SM (1) SMP201100019B (es)
SV (1) SV2011003853A (es)
TN (1) TN2011000053A1 (es)
TW (1) TWI453206B (es)
UA (1) UA104147C2 (es)
UY (1) UY32096A (es)
WO (1) WO2010029082A1 (es)
ZA (1) ZA201100699B (es)

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TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
MX336723B (es) 2008-07-11 2016-01-28 Novartis Ag Combinacion de (a) un inhibidor de fosfoinositido 3-cinasa y (b) un modulador de la ruta de ras/raf/mek.
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
AU2015203865B2 (en) * 2010-11-08 2016-11-03 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
KR101854484B1 (ko) * 2010-11-08 2018-05-03 노파르티스 아게 Ｅｇｆｒ 의존성 질환 또는 ｅｇｆｒ 족 구성원을 표적으로 하는 작용제에 대한 내성을 획득한 질환의 치료에서의 2-카르복사미드 시클로아미노 우레아 유도체의 용도
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
AR086481A1 (es) * 2011-04-25 2013-12-18 Novartis Ag COMBINACION DE UN INHIBIDOR DE CINASA DE FOSFATIDIL-INOSITOL-3 (PI3K), Y UN INHIBIDOR DE mTOR
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KR20140040770A (ko) * 2011-07-01 2014-04-03 노파르티스 아게 암 치료에 사용하기 위한 cdk4/6 억제제 및 pi3k 억제제를 포함하는 조합 요법
KR20140072028A (ko) * 2011-08-31 2014-06-12 노파르티스 아게 Pi3k- 및 mek-억제제의 상승작용적 조합물
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JP6180420B2 (ja) 2011-10-14 2017-08-16 ノバルティス アーゲー 増殖性疾患の治療のためのｈｓｐ９０阻害剤と組み合わせた２−カルボキサミドシクロアミノウレア誘導体
BR112014009993A2 (pt) 2011-10-28 2017-04-25 Novartis Ag método para o tratamento de tumores do estroma gastrointestinal
RU2014122198A (ru) 2011-11-02 2015-12-10 Новартис Аг Производные 2-карбоксамид циклоамино мочевины для применения в лечении vegf-зависимых заболеваний
US9458147B2 (en) 2012-02-22 2016-10-04 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as TNAP inhibitors
KR20140138771A (ko) 2012-03-29 2014-12-04 노파르티스 아게 제약학적 진단법
CN104244949A (zh) * 2012-03-30 2014-12-24 诺华股份有限公司 用于治疗神经母细胞瘤、尤文氏肉瘤或横纹肌肉瘤的化合物
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