CY1117078T1 - Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων - Google Patents

Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

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Publication number
CY1117078T1
CY1117078T1 CY20151101197T CY151101197T CY1117078T1 CY 1117078 T1 CY1117078 T1 CY 1117078T1 CY 20151101197 T CY20151101197 T CY 20151101197T CY 151101197 T CY151101197 T CY 151101197T CY 1117078 T1 CY1117078 T1 CY 1117078T1
Authority
CY
Cyprus
Prior art keywords
riskinisminal
phosphidrisilisnacilin
heterarylythesisol
carboxamidis
aminocarbonyl
Prior art date
Application number
CY20151101197T
Other languages
English (en)
Inventor
Giorgio Caravatti
Robin Alec Fairhurst
Pascal Furet
Vito Guagnano
Patricia Imbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40350060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117078(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1117078T1 publication Critical patent/CY1117078T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Η παρούσα εφεύρεση σχετίζεται με μια ένωση του χημικού τύπου (I) ή ενός άλατος αυτού, όπου οι υποκαταστάτες είναι όπως περιγράφηκαν στην περιγραφή, με συνθέσεις και με τη χρήση των ενώσεων στη θεραπεία νόσων οι οποίες βελτιώνονται από την αναστολή της φωσφατιδυλινοσιτολ 3-κινάσης.
CY20151101197T 2008-09-10 2015-12-29 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων CY1117078T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08164104 2008-09-10
US9667408P 2008-09-12 2008-09-12
EP09782777.8A EP2331537B1 (en) 2008-09-10 2009-09-08 1-((5-heteroarylthiazol-2-yl)aminocarbonyl)pyrrolidine-2-carboxamide derivatives as phosphatidylinositol 3-kinase (pi3k) inhibitors useful in the treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
CY1117078T1 true CY1117078T1 (el) 2017-04-05

Family

ID=40350060

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151101197T CY1117078T1 (el) 2008-09-10 2015-12-29 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων
CY2020037C CY2020037I2 (el) 2008-09-10 2020-11-24 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

Family Applications After (1)

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CY2020037C CY2020037I2 (el) 2008-09-10 2020-11-24 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

Country Status (49)

Country Link
US (4) US8227462B2 (el)
EP (1) EP2331537B1 (el)
JP (1) JP5486601B2 (el)
KR (1) KR101290844B1 (el)
CN (1) CN102149711B (el)
AR (2) AR073369A1 (el)
AU (1) AU2009290904B2 (el)
BR (1) BRPI0918750B8 (el)
CA (1) CA2734819C (el)
CL (1) CL2011000504A1 (el)
CO (1) CO6351738A2 (el)
CR (1) CR20110059A (el)
CU (1) CU24000B1 (el)
CY (2) CY1117078T1 (el)
DK (1) DK2331537T3 (el)
DO (1) DOP2011000070A (el)
EA (1) EA018863B1 (el)
EC (1) ECSP11010880A (el)
ES (1) ES2560673T3 (el)
GE (1) GEP20135991B (el)
HK (1) HK1156305A1 (el)
HN (1) HN2011000699A (el)
HR (1) HRP20160014T1 (el)
HU (2) HUE025884T2 (el)
IL (1) IL210976A (el)
JO (1) JO3121B1 (el)
LT (1) LTC2331537I2 (el)
MA (1) MA32604B1 (el)
ME (1) ME01284B (el)
MX (1) MX2011002597A (el)
MY (1) MY151556A (el)
NI (1) NI201100049A (el)
NL (1) NL301071I2 (el)
NO (1) NO2020037I1 (el)
NZ (1) NZ590754A (el)
PA (1) PA8841901A1 (el)
PE (1) PE20110796A1 (el)
PL (1) PL2331537T3 (el)
PT (1) PT2331537E (el)
RS (1) RS54476B1 (el)
SI (1) SI2331537T1 (el)
SM (1) SMP201100019B (el)
SV (1) SV2011003853A (el)
TN (1) TN2011000053A1 (el)
TW (1) TWI453206B (el)
UA (1) UA104147C2 (el)
UY (1) UY32096A (el)
WO (1) WO2010029082A1 (el)
ZA (1) ZA201100699B (el)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
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AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
CA2729914A1 (en) 2008-07-11 2010-01-14 Novartis Ag Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
AU2015203865B2 (en) * 2010-11-08 2016-11-03 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
CN105412105A (zh) * 2010-11-08 2016-03-23 诺华有限公司 2-甲酰胺环氨基尿素衍生物在治疗egfr依赖性疾病或对靶向egfr家族成员的药剂有获得性耐受性的疾病中的应用
UA112539C2 (uk) 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
BR112013027486A2 (pt) * 2011-04-25 2017-02-14 Novartis Ag combinação de um inibidor de fosfatidilinositol-3-cinase (pi3k) e um inibidor de mtor
US9006270B2 (en) 2011-06-21 2015-04-14 Novartis Ag Polymorphs of (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide
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