AR112074A2 - Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 - Google Patents
Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3Info
- Publication number
- AR112074A2 AR112074A2 ARP180101520A ARP180101520A AR112074A2 AR 112074 A2 AR112074 A2 AR 112074A2 AR P180101520 A ARP180101520 A AR P180101520A AR P180101520 A ARP180101520 A AR P180101520A AR 112074 A2 AR112074 A2 AR 112074A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- cycloamine
- carboxamide
- urea
- inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Transplantation (AREA)
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- Vascular Medicine (AREA)
Abstract
La presente solicitud se refiere a un compuesto o a una sal del mismo, a composiciones y al uso del compuesto en el tratamiento de enfermedades que mejoran mediante la inhibición de la cinasa de fosfatidil-inositol-3. Reivindicación 1: El compuesto (S)-1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido pirrolidin-1,2-dicarboxílico, de estructura de fórmula (1), en forma libre o en forma de una sal farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08164104 | 2008-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR112074A2 true AR112074A2 (es) | 2019-09-18 |
Family
ID=40350060
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103437A AR073369A1 (es) | 2008-09-10 | 2009-09-08 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
ARP180101520A AR112074A2 (es) | 2008-09-10 | 2018-06-06 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103437A AR073369A1 (es) | 2008-09-10 | 2009-09-08 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
Country Status (50)
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
KR20110028651A (ko) | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (a) 포스포이노시타이드 3-키나제 억제제 및 (b) ras/raf/mek 경로의 조절제의 조합물 |
UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
AU2011328227B2 (en) * | 2010-11-08 | 2015-04-09 | Novartis Ag | Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members |
AU2015203865B2 (en) * | 2010-11-08 | 2016-11-03 | Novartis Ag | Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members |
UA112539C2 (uk) * | 2011-03-03 | 2016-09-26 | Новартіс Аг | Спосіб одержання похідних 2-карбоксамідциклоаміносечовини |
JP6086902B2 (ja) * | 2011-04-25 | 2017-03-01 | ノバルティス アーゲー | ホスファチジルイノシトール−3−キナーゼ(PI3K)阻害剤およびmTOR阻害剤の組み合わせ |
JP2014517049A (ja) * | 2011-06-21 | 2014-07-17 | ノバルティス アーゲー | (s)−ピロリジン−1,2−ジカルボン酸2−アミド1−({4−メチル−5−[2−(2,2,2−トリフルオロ−1,1−ジメチル−エチル)−ピリジン−4−イル]−チアゾール−2−イル}−アミドの多形 |
JP5832647B2 (ja) | 2011-07-01 | 2015-12-16 | ノバルティス アーゲー | がんの治療における使用のためのcdk4/6阻害剤およびpi3k阻害剤を含む併用療法 |
MX2014002471A (es) * | 2011-08-31 | 2014-03-27 | Novartis Ag | Combinaciones sinergicas de los inhibidores de p13k y mek. |
US20140235630A1 (en) * | 2011-09-30 | 2014-08-21 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for the treatment of proliferative diseases |
BR112014008400A2 (pt) * | 2011-10-14 | 2017-04-04 | Novartis Ag | derivados de 2-carboxamida cicloamino ureia em combinação com os inibidores de hsp90 para o tratamento de doenças proliferativas |
AU2012328979B2 (en) * | 2011-10-28 | 2016-04-21 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
JP2014532684A (ja) * | 2011-11-02 | 2014-12-08 | ノバルティス アーゲー | Vegf依存性疾患の治療に使用する2−カルボキサミドシクロアミノウレア誘導体 |
US9458147B2 (en) * | 2012-02-22 | 2016-10-04 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as TNAP inhibitors |
WO2013144249A1 (en) | 2012-03-29 | 2013-10-03 | Novartis Ag | Pharmaceutical diagnostic |
WO2013148912A1 (en) | 2012-03-30 | 2013-10-03 | Novartis Ag | Compounds for use in the treatment of neuroblastoma, ewing's sarcoma or rhabdomyosarcoma |
KR20160027218A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
US8980259B2 (en) * | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
HUE042877T2 (hu) * | 2012-08-07 | 2019-07-29 | Novartis Ag | Gyógyászati kombinációk egy B-Raf inhibitor, egy EGFR inhibitor és adott esetben egy PI13K-alfa inhibitor tartalommal |
MX369518B (es) * | 2012-08-16 | 2019-11-11 | Novartis Ag | Combinacion de inhibidor de p13k e inhibidor de c-met. |
MX356278B (es) * | 2012-09-20 | 2018-05-22 | Novartis Ag | Combinacion farmaceutica que comprende un inhibidor de fosfatidilinositol 3-cinasa y un inhibidor de aromatasa. |
CN104797553B (zh) * | 2012-11-16 | 2017-07-21 | 默克专利股份公司 | 3‑氨基环戊烷甲酰胺衍生物 |
EP3251673A1 (en) | 2012-12-13 | 2017-12-06 | IP Gesellschaft für Management mbH | Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer |
PE20151979A1 (es) | 2013-01-23 | 2016-01-15 | Astrazeneca Ab | Compuestos quimicos |
BR112015023203A8 (pt) | 2013-03-15 | 2018-01-23 | Constellation Pharmaceuticals Inc | métodos para tratamento de câncer, método para aumentar a eficiência de um tratamento de câncer, método para retardar e/ou prevenir o desenvolvimento de câncer, método para tratar um indivíduo com câncer, método para aumentar a sensibilidade para um agente de terapia para câncer, método para estender um período de sensibilidade e método para estender a duração da resposta para uma terapia para câncer. |
DK2976106T3 (da) * | 2013-03-21 | 2021-06-14 | Array Biopharma Inc | Kombinationsterapi, som omfatter en b-raf-hæmmer og en anden hæmmer |
KR20150123931A (ko) * | 2013-04-05 | 2015-11-04 | 사노피 | Pi3k베타-선택적 억제제 및 pi3k알파-선택적 억제제를 포함하는 항-종양 조성물 |
WO2014191938A1 (en) | 2013-05-31 | 2014-12-04 | Novartis Ag | Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer |
KR20160018531A (ko) | 2013-06-11 | 2016-02-17 | 노파르티스 아게 | Pi3k 억제제 및 미세관 탈안정화제의 제약 조합물 |
AU2014282798A1 (en) | 2013-06-18 | 2015-12-03 | Novartis Ag | Pharmaceutical combinations |
JP2016527305A (ja) | 2013-08-08 | 2016-09-08 | ノバルティス アーゲー | Pimキナーゼ阻害剤の組合せ |
CA2918190C (en) | 2013-08-14 | 2023-01-17 | Novartis Ag | Combination therapy comprising a cdk4/6 inhibitor and an aromatase inhibitor or fulvestrant for the treatment of cancer |
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- 2020-11-18 HU HUS2000044C patent/HUS2000044I1/hu unknown
- 2020-11-20 LU LU00186C patent/LUC00186I2/fr unknown
- 2020-11-24 CY CY2020037C patent/CY2020037I1/el unknown
- 2020-11-25 LT LTPA2020534C patent/LTC2331537I2/lt unknown
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