AR112074A2 - Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 - Google Patents
Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3Info
- Publication number
- AR112074A2 AR112074A2 ARP180101520A ARP180101520A AR112074A2 AR 112074 A2 AR112074 A2 AR 112074A2 AR P180101520 A ARP180101520 A AR P180101520A AR P180101520 A ARP180101520 A AR P180101520A AR 112074 A2 AR112074 A2 AR 112074A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- cycloamine
- carboxamide
- urea
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
Abstract
La presente solicitud se refiere a un compuesto o a una sal del mismo, a composiciones y al uso del compuesto en el tratamiento de enfermedades que mejoran mediante la inhibición de la cinasa de fosfatidil-inositol-3. Reivindicación 1: El compuesto (S)-1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido pirrolidin-1,2-dicarboxílico, de estructura de fórmula (1), en forma libre o en forma de una sal farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08164104 | 2008-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112074A2 true AR112074A2 (es) | 2019-09-18 |
Family
ID=40350060
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103437A AR073369A1 (es) | 2008-09-10 | 2009-09-08 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
| ARP180101520A AR112074A2 (es) | 2008-09-10 | 2018-06-06 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103437A AR073369A1 (es) | 2008-09-10 | 2009-09-08 | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 |
Country Status (50)
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| KR20110028651A (ko) | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (ａ) 포스포이노시타이드 3-키나제 억제제 및 (ｂ) ｒａｓ/ｒａｆ/ｍｅｋ 경로의 조절제의 조합물 |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| AU2011328227B2 (en) * | 2010-11-08 | 2015-04-09 | Novartis Ag | Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members |
| AU2015203865B2 (en) * | 2010-11-08 | 2016-11-03 | Novartis Ag | Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members |
| UA112539C2 (uk) * | 2011-03-03 | 2016-09-26 | Новартіс Аг | Спосіб одержання похідних 2-карбоксамідциклоаміносечовини |
| JP6086902B2 (ja) * | 2011-04-25 | 2017-03-01 | ノバルティス アーゲー | ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤およびｍＴＯＲ阻害剤の組み合わせ |
| JP2014517049A (ja) * | 2011-06-21 | 2014-07-17 | ノバルティス アーゲー | （ｓ）−ピロリジン−１，２−ジカルボン酸２−アミド１−（｛４−メチル−５−［２−（２，２，２−トリフルオロ−１，１−ジメチル−エチル）−ピリジン−４−イル］−チアゾール−２−イル｝−アミドの多形 |
| JP5832647B2 (ja) | 2011-07-01 | 2015-12-16 | ノバルティス アーゲー | がんの治療における使用のためのｃｄｋ４／６阻害剤およびｐｉ３ｋ阻害剤を含む併用療法 |
| MX2014002471A (es) * | 2011-08-31 | 2014-03-27 | Novartis Ag | Combinaciones sinergicas de los inhibidores de p13k y mek. |
| US20140235630A1 (en) * | 2011-09-30 | 2014-08-21 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for the treatment of proliferative diseases |
| BR112014008400A2 (pt) * | 2011-10-14 | 2017-04-04 | Novartis Ag | derivados de 2-carboxamida cicloamino ureia em combinação com os inibidores de hsp90 para o tratamento de doenças proliferativas |
| AU2012328979B2 (en) * | 2011-10-28 | 2016-04-21 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
| JP2014532684A (ja) * | 2011-11-02 | 2014-12-08 | ノバルティス アーゲー | Ｖｅｇｆ依存性疾患の治療に使用する２−カルボキサミドシクロアミノウレア誘導体 |
| US9458147B2 (en) * | 2012-02-22 | 2016-10-04 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as TNAP inhibitors |
| WO2013144249A1 (en) | 2012-03-29 | 2013-10-03 | Novartis Ag | Pharmaceutical diagnostic |
| WO2013148912A1 (en) | 2012-03-30 | 2013-10-03 | Novartis Ag | Compounds for use in the treatment of neuroblastoma, ewing's sarcoma or rhabdomyosarcoma |
| KR20160027218A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| US8980259B2 (en) * | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| HUE042877T2 (hu) * | 2012-08-07 | 2019-07-29 | Novartis Ag | Gyógyászati kombinációk egy B-Raf inhibitor, egy EGFR inhibitor és adott esetben egy PI13K-alfa inhibitor tartalommal |
| MX369518B (es) * | 2012-08-16 | 2019-11-11 | Novartis Ag | Combinacion de inhibidor de p13k e inhibidor de c-met. |
| MX356278B (es) * | 2012-09-20 | 2018-05-22 | Novartis Ag | Combinacion farmaceutica que comprende un inhibidor de fosfatidilinositol 3-cinasa y un inhibidor de aromatasa. |
| CN104797553B (zh) * | 2012-11-16 | 2017-07-21 | 默克专利股份公司 | 3‑氨基环戊烷甲酰胺衍生物 |
| EP3251673A1 (en) | 2012-12-13 | 2017-12-06 | IP Gesellschaft für Management mbH | Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer |
| PE20151979A1 (es) | 2013-01-23 | 2016-01-15 | Astrazeneca Ab | Compuestos quimicos |
| BR112015023203A8 (pt) | 2013-03-15 | 2018-01-23 | Constellation Pharmaceuticals Inc | métodos para tratamento de câncer, método para aumentar a eficiência de um tratamento de câncer, método para retardar e/ou prevenir o desenvolvimento de câncer, método para tratar um indivíduo com câncer, método para aumentar a sensibilidade para um agente de terapia para câncer, método para estender um período de sensibilidade e método para estender a duração da resposta para uma terapia para câncer. |
| DK2976106T3 (da) * | 2013-03-21 | 2021-06-14 | Array Biopharma Inc | Kombinationsterapi, som omfatter en b-raf-hæmmer og en anden hæmmer |
| KR20150123931A (ko) * | 2013-04-05 | 2015-11-04 | 사노피 | Pi3k베타-선택적 억제제 및 pi3k알파-선택적 억제제를 포함하는 항-종양 조성물 |
| WO2014191938A1 (en) | 2013-05-31 | 2014-12-04 | Novartis Ag | Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer |
| KR20160018531A (ko) | 2013-06-11 | 2016-02-17 | 노파르티스 아게 | Pi3k 억제제 및 미세관 탈안정화제의 제약 조합물 |
| AU2014282798A1 (en) | 2013-06-18 | 2015-12-03 | Novartis Ag | Pharmaceutical combinations |
| JP2016527305A (ja) | 2013-08-08 | 2016-09-08 | ノバルティス アーゲー | Ｐｉｍキナーゼ阻害剤の組合せ |
| CA2918190C (en) | 2013-08-14 | 2023-01-17 | Novartis Ag | Combination therapy comprising a cdk4/6 inhibitor and an aromatase inhibitor or fulvestrant for the treatment of cancer |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| KR20160095035A (ko) * | 2013-12-06 | 2016-08-10 | 노파르티스 아게 | 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법 |
| RU2016133285A (ru) * | 2014-01-15 | 2018-02-20 | Новартис Аг | Фармацевтические комбинации |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| RU2016135413A (ru) | 2014-02-11 | 2018-03-14 | Новартис Аг | Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака |
| TWI697500B (zh) | 2014-03-14 | 2020-07-01 | 瑞士商諾華公司 | 針對ｌａｇ-３之抗體分子及其用途 |
| AU2015314756A1 (en) | 2014-09-13 | 2017-03-16 | Novartis Ag | Combination therapies of alk inhibitors |
| PL3200772T3 (pl) | 2014-10-03 | 2022-12-19 | Novartis Ag | Kompozycje farmaceutyczne zawierające alpelisyb |
| JP2017535528A (ja) | 2014-10-03 | 2017-11-30 | ノバルティス アーゲー | 組み合わせ治療 |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US9988452B2 (en) | 2014-10-14 | 2018-06-05 | Novartis Ag | Antibody molecules to PD-L1 and uses thereof |
| CN104844589B (zh) * | 2014-12-26 | 2018-04-20 | 中国科学院合肥物质科学研究院 | 一种pi3k激酶抑制剂 |
| CR20170410A (es) | 2015-03-10 | 2017-11-08 | Aduro Biotech Inc | Composiciones y métodos para activar la señalización dependiente del "estimulador del gen interferon" |
| CN107787226A (zh) * | 2015-03-25 | 2018-03-09 | 诺华股份有限公司 | 药物组合 |
| KR20180012324A (ko) | 2015-06-29 | 2018-02-05 | 에프. 호프만-라 로슈 아게 | 타셀리십을 사용하는 치료 방법 |
| UA121678C2 (uk) | 2015-07-02 | 2020-07-10 | Ф. Хоффманн-Ля Рош Аг | Сполука бензоксазепіноксазолідинонів та способи застосування |
| EP4378957A3 (en) | 2015-07-29 | 2024-08-07 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| EP3964528A1 (en) | 2015-07-29 | 2022-03-09 | Novartis AG | Combination therapies comprising antibody molecules to lag-3 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| US10328066B2 (en) | 2015-08-28 | 2019-06-25 | Novartis Ag | Pharmaceutical combination comprising the PI3K inhibitor alpelisib and the CDK4/6 inhibitor ribociclib, and the use thereof in the treatment/prevention of cancer |
| CN107921026A (zh) * | 2015-08-28 | 2018-04-17 | 诺华股份有限公司 | 药物组合物包含(a)α‑同种型特异性PI3K抑制剂alpelisib(BYL719)和(b)AKT抑制剂,优选MK‑2206,afuresertib或uprosertib及其在治疗/预防癌症中的应用 |
| WO2017037587A1 (en) | 2015-08-28 | 2017-03-09 | Novartis Ag | Combination of ribociclib and dabrafenib for treating or preventing cancer |
| EP4241850A3 (en) | 2015-08-28 | 2023-11-08 | Novartis AG | Mdm2 inhibitors and combinations thereof |
| CN108135905A (zh) | 2015-08-28 | 2018-06-08 | 诺华股份有限公司 | 用于治疗癌症的cdk4/6抑制剂lee011、mek1/2抑制剂曲美替尼以及可任选还包括pi3k抑制剂byl719的组合 |
| WO2017037586A1 (en) | 2015-08-28 | 2017-03-09 | Novartis Ag | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
| TW201726140A (zh) | 2015-09-17 | 2017-08-01 | 瑞典商阿斯特捷利康公司 | 治療癌症之新型生物標記及方法 |
| CN105294546B (zh) * | 2015-10-29 | 2017-12-08 | 天津市斯芬克司药物研发有限公司 | 一种吡啶化合物及其制备方法 |
| EP3370719A1 (en) | 2015-11-02 | 2018-09-12 | Novartis AG | Dosage regimen for a phosphatidylinositol 3-kinase inhibitor |
| CA3004138A1 (en) | 2015-11-03 | 2017-05-11 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and tim-3 and their uses |
| CN108366998A (zh) | 2015-12-03 | 2018-08-03 | 诺华股份有限公司 | 在ctdna中具有pik3ca突变的预选患者中用pi3k抑制剂治疗癌症 |
| JP2019503349A (ja) | 2015-12-17 | 2019-02-07 | ノバルティス アーゲー | Ｐｄ−１に対する抗体分子およびその使用 |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
| WO2018092064A1 (en) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinations of mdm2 inhibitors and bcl-xl inhibitors |
| CN106674200B (zh) * | 2016-12-21 | 2019-04-12 | 西安交通大学 | 一种含有l-脯氨酰胺片段的化合物及其制备方法和应用 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| US11312783B2 (en) | 2017-06-22 | 2022-04-26 | Novartis Ag | Antibody molecules to CD73 and uses thereof |
| US20200172628A1 (en) | 2017-06-22 | 2020-06-04 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2019073031A1 (en) | 2017-10-13 | 2019-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | POLYTHERAPY OF PANCREATIC CANCER |
| EP3713963A1 (en) | 2017-11-23 | 2020-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new marker for predicting the sensitivity to pi3k inhibitors |
| WO2019106604A1 (en) | 2017-12-01 | 2019-06-06 | Novartis Ag | Pharmaceutical combination comprising lsz102 and alpelisib |
| JP7245834B2 (ja) * | 2017-12-08 | 2023-03-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを作成するためのプロセス |
| CR20240101A (es) | 2018-03-08 | 2024-05-24 | Incyte Corp | COMPUESTOS DIÓLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-y (DIVISIONAL 2020-464) |
| TW202015726A (zh) | 2018-05-30 | 2020-05-01 | 瑞士商諾華公司 | Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法 |
| JP7456945B2 (ja) | 2018-05-30 | 2024-03-27 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | 三環式誘導体を含む阻害剤、その製造方法、及び使用 |
| US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| EP3849545A1 (en) * | 2018-09-10 | 2021-07-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of neurofibromatosis |
| WO2020072892A1 (en) * | 2018-10-05 | 2020-04-09 | Sloan-Kettering Institute For Cancer Research | Pi3k inhibitors and uses thereof |
| CN113195000A (zh) | 2018-12-21 | 2021-07-30 | 第一三共株式会社 | 抗体-药物缀合物和激酶抑制剂的组合 |
| EP3971175A4 (en) | 2019-05-13 | 2022-11-09 | Luoxin Healthcare Science and Technology Development (Beijing) Ltd. | CRYSTAL FORM OF A QUINAZOLINONE COMPOUND AND PROCESS FOR THEIR PRODUCTION |
| CN111995541A (zh) * | 2019-05-27 | 2020-11-27 | 润佳（苏州）医药科技有限公司 | 含有稳定重同位素的酰胺官能团的化合物及其应用 |
| WO2021001427A1 (en) | 2019-07-02 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prophylactic treatment of cancer in patients suffering from pancreatitis |
| US20220354452A1 (en) | 2019-07-02 | 2022-11-10 | Inserm (Institut National De La Santé Et De La Rechrche Médical) | Use of ultrafast elasticity imaging for detecting pancreatic cancers |
| WO2021001431A1 (en) | 2019-07-02 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3ka-selective inhibitors for treating metastatic disease in patients suffering from pancreatic cancer |
| EP4031578A1 (en) | 2019-09-18 | 2022-07-27 | Novartis AG | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| AU2020389670A1 (en) | 2019-11-25 | 2022-05-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Three fused ring derivative-containing salt or crystal form and pharmaceutical composition thereof |
| CN113045564B (zh) * | 2019-12-27 | 2024-09-20 | 上海天慈国际药业有限公司 | 一种阿培利司的制备方法 |
| WO2021189143A1 (en) * | 2020-03-25 | 2021-09-30 | Risen (Suzhou) Pharma Tech Co., Ltd. | Stable heavy isotopes in amide functional groups and uses thereof |
| WO2022016420A1 (zh) * | 2020-07-22 | 2022-01-27 | 罗欣药业(上海)有限公司 | 一种喹唑啉酮类化合物的晶型、其制备方法及应用 |
| KR20240004683A (ko) | 2021-05-03 | 2024-01-11 | 노파르티스 아게 | 알펠리십 제형 |
| CN115611883A (zh) * | 2021-07-13 | 2023-01-17 | 生物岛实验室 | 一种双环结构的PI3Kα抑制剂及其制备方法和用途 |
| CA3237812A1 (en) * | 2021-11-12 | 2023-05-19 | Biopolar Youtang (Guangdong) Pharmaceutical Co., Ltd. | Drak2 inhibitor, and preparation method therefor and use thereof |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
| WO2024089272A1 (en) | 2022-10-28 | 2024-05-02 | Institut National De La Sante Et De La Recherche Medicale | New inhibitors of phosphatidylinositol 3-kinase |
| WO2024100236A1 (en) | 2022-11-11 | 2024-05-16 | Astrazeneca Ab | Combination therapies for the treatment of cancer |
| WO2024206147A1 (en) | 2023-03-24 | 2024-10-03 | Arvinas Operations, Inc. | Dosage regimens of estrogen receptor degraders |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649146A (en) * | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
| DE3703435A1 (de) | 1987-02-05 | 1988-08-18 | Thomae Gmbh Dr K | Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| ATE107280T1 (de) | 1988-04-15 | 1994-07-15 | Taiho Pharmaceutical Co Ltd | Carbamoyl-2-pyrrolidinonverbindungen. |
| US5028726A (en) * | 1990-02-07 | 1991-07-02 | The University Of Vermont And State Agricultural College | Platinum amine sulfoxide complexes |
| US5780653A (en) * | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| EP0946587A2 (en) | 1996-12-16 | 1999-10-06 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds |
| US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| WO1998035036A1 (en) * | 1997-02-10 | 1998-08-13 | Genentech, Inc. | Heregulin variants |
| CA2302417A1 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
| JP2002518380A (ja) | 1998-06-18 | 2002-06-25 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤 |
| EE200200123A (et) * | 1999-09-10 | 2003-08-15 | Merck & Co., Inc. | Türosiinkinaasi pärssiv ühend, seda sisaldav farmatseutiline kompositsioon ning raviotstarbeline kasutamine |
| GB0000313D0 (en) * | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| IL151946A0 (en) * | 2000-03-29 | 2003-04-10 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
| TWI304061B (en) | 2000-10-20 | 2008-12-11 | Eisai R&D Man Co Ltd | Nitrogen-containing aromatic ring derivatives |
| DE60208630T2 (de) | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| KR100979988B1 (ko) * | 2001-08-13 | 2010-09-03 | 얀센 파마슈티카 엔.브이. | 2-아미노-4,5-삼치환 티아졸릴 유도체 |
| WO2003015778A1 (en) | 2001-08-17 | 2003-02-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| IL161092A0 (en) * | 2001-09-28 | 2004-08-31 | Cyclacel Ltd | N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-n-phenylamines as antiproliferative compounds |
| TWI314928B (en) | 2002-02-28 | 2009-09-21 | Novartis A | 5-phenylthiazole derivatives and use as pi3 kinase inhibitors |
| CA2504320A1 (en) * | 2002-10-30 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
| US7632858B2 (en) | 2002-11-15 | 2009-12-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
| WO2004062604A2 (en) * | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| GB0305152D0 (en) | 2003-03-06 | 2003-04-09 | Novartis Ag | Organic compounds |
| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| GB0320197D0 (en) * | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| JP2007504255A (ja) | 2003-09-06 | 2007-03-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターの調節因子 |
| AU2005205201B2 (en) | 2004-01-12 | 2011-05-12 | Merck Serono Sa | Thiazole derivatives and use thereof |
| AU2005260032A1 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 and LCK activity |
| SE0402735D0 (sv) | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| EP1853250B1 (en) * | 2005-02-18 | 2011-11-02 | Abraxis BioScience, LLC | Combinations and modes of administration of therapeutic agents and combination therapy |
| DE102005024157A1 (de) | 2005-05-23 | 2006-11-30 | Amedo Gmbh | Nadelpositioniersystem |
| MX2007014883A (es) | 2005-05-24 | 2008-02-15 | Serono Lab | Derivados de tiazol y uso de los mismos. |
| WO2006125807A1 (en) | 2005-05-24 | 2006-11-30 | Laboratoires Serono S.A. | Thiazole derivatives and use thereof |
| DE102005024790A1 (de) | 2005-05-26 | 2006-12-07 | Eos Gmbh Electro Optical Systems | Strahlungsheizung zum Heizen des Aufbaumaterials in einer Lasersintervorrichtung |
| US7655446B2 (en) * | 2005-06-28 | 2010-02-02 | Vertex Pharmaceuticals Incorporated | Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof |
| DE102005048072A1 (de) | 2005-09-24 | 2007-04-05 | Bayer Cropscience Ag | Thiazole als Fungizide |
| JP2009519346A (ja) | 2005-12-12 | 2009-05-14 | ジェネラブズ テクノロジーズ インコーポレーティッド | Ｎ−（５員芳香族環）−アミド抗ウイルス化合物 |
| GB0525671D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| AU2007206860A1 (en) * | 2006-01-23 | 2007-07-26 | Laboratoires Serono S.A. | Thiazole derivatives and use thereof |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| WO2007129044A1 (en) * | 2006-05-03 | 2007-11-15 | Astrazeneca Ab | Thiazole derivatives and their use as anti-tumour agents |
| GB0610243D0 (en) | 2006-05-23 | 2006-07-05 | Novartis Ag | Organic compounds |
| GB0612630D0 (en) * | 2006-06-26 | 2006-08-02 | Novartis Ag | Organic compounds |
| FR2904190B1 (fr) | 2006-07-25 | 2008-12-12 | Inst Rech Pour Le Dev I R D Et | Utilisation d'inocula fongiques pour l'amelioration de la production maraichere |
| TW200827368A (en) | 2006-11-21 | 2008-07-01 | Genelabs Tech Inc | Amido anti-viral compounds |
| WO2008124000A2 (en) | 2007-04-02 | 2008-10-16 | Ligand Pharmaceuticals Incorporated | Thiazole derivatives as androgen receptor modulator compounds |
| RU2479577C2 (ru) | 2007-05-25 | 2013-04-20 | Эбботт Гмбх Унд Ко.Кг | Гетероциклические соединения в качестве положительных модуляторов метаботропного глутаматного рецептора 2 (рецептора mglu2) |
| US20090004140A1 (en) | 2007-06-26 | 2009-01-01 | Yao-Ling Qiu | 4-substituted pyrrolidine as anti-infectives |
| PT2178865E (pt) | 2007-07-19 | 2015-11-16 | Lundbeck & Co As H | Amidas heterocíclicas com 5 membros e compostos relacionados |
| ITMI20072396A1 (it) | 2007-12-20 | 2009-06-21 | Dachi S R L | "apparato di chiusura di contenitori di materiale biologico" |
| EA201000947A1 (ru) * | 2007-12-20 | 2011-02-28 | Новартис Аг | Производные тиазола, применимые в качестве ингибиторов киназы pi3 |
| US20100298286A1 (en) | 2007-12-20 | 2010-11-25 | Novartis Ag | Organic Compounds |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
-
2009
- 2009-08-09 UA UAA201102837A patent/UA104147C2/uk unknown
- 2009-09-08 BR BRPI0918750A patent/BRPI0918750B8/pt active IP Right Grant
- 2009-09-08 EP EP09782777.8A patent/EP2331537B1/en active Active
- 2009-09-08 DK DK09782777.8T patent/DK2331537T3/en active
- 2009-09-08 ES ES09782777.8T patent/ES2560673T3/es active Active
- 2009-09-08 AU AU2009290904A patent/AU2009290904B2/en active Active
- 2009-09-08 PT PT97827778T patent/PT2331537E/pt unknown
- 2009-09-08 JP JP2011526479A patent/JP5486601B2/ja active Active
- 2009-09-08 NZ NZ590754A patent/NZ590754A/xx unknown
- 2009-09-08 ME MEP-2011-21A patent/ME01284B/me unknown
- 2009-09-08 CA CA2734819A patent/CA2734819C/en active Active
- 2009-09-08 AR ARP090103437A patent/AR073369A1/es not_active Application Discontinuation
- 2009-09-08 SI SI200931344T patent/SI2331537T1/sl unknown
- 2009-09-08 EA EA201100447A patent/EA018863B1/ru active Protection Beyond IP Right Term
- 2009-09-08 HU HUE09782777A patent/HUE025884T2/en unknown
- 2009-09-08 CN CN200980135415.7A patent/CN102149711B/zh active Active
- 2009-09-08 GE GEAP200912132A patent/GEP20135991B/en unknown
- 2009-09-08 UY UY0001032096A patent/UY32096A/es active IP Right Grant
- 2009-09-08 WO PCT/EP2009/061644 patent/WO2010029082A1/en active Application Filing
- 2009-09-08 PL PL09782777T patent/PL2331537T3/pl unknown
- 2009-09-08 MY MYPI20110510 patent/MY151556A/en unknown
- 2009-09-08 MX MX2011002597A patent/MX2011002597A/es active IP Right Grant
- 2009-09-08 KR KR1020117005524A patent/KR101290844B1/ko active IP Right Grant
- 2009-09-08 PE PE2011000591A patent/PE20110796A1/es active IP Right Grant
- 2009-09-08 RS RS20150860A patent/RS54476B1/en unknown
- 2009-09-09 TW TW098130412A patent/TWI453206B/zh active
- 2009-09-09 JO JOP/2009/0334A patent/JO3121B1/ar active
- 2009-09-10 PA PA20098841901A patent/PA8841901A1/es unknown
- 2009-09-10 US US12/556,964 patent/US8227462B2/en active Active
-
2011
- 2011-01-27 ZA ZA2011/00699A patent/ZA201100699B/en unknown
- 2011-01-31 IL IL210976A patent/IL210976A/en active IP Right Grant
- 2011-01-31 TN TN2011000053A patent/TN2011000053A1/fr unknown
- 2011-02-01 CR CR20110059A patent/CR20110059A/es unknown
- 2011-03-01 MA MA33661A patent/MA32604B1/fr unknown
- 2011-03-07 DO DO2011000070A patent/DOP2011000070A/es unknown
- 2011-03-08 HN HN2011000699A patent/HN2011000699A/es unknown
- 2011-03-09 CL CL2011000504A patent/CL2011000504A1/es unknown
- 2011-03-09 NI NI201100049A patent/NI201100049A/es unknown
- 2011-03-10 SV SV2011003853A patent/SV2011003853A/es unknown
- 2011-03-10 CU CU2011000052A patent/CU24000B1/es active IP Right Grant
- 2011-03-10 EC EC2011010880A patent/ECSP11010880A/es unknown
- 2011-03-17 CO CO11033546A patent/CO6351738A2/es active IP Right Grant
- 2011-04-07 SM SM201100019T patent/SMP201100019B/it unknown
- 2011-10-04 HK HK11110482.1A patent/HK1156305A1/xx unknown
-
2012
- 2012-06-05 US US13/488,589 patent/US8476268B2/en active Active
-
2013
- 2013-05-24 US US13/901,930 patent/US8710085B2/en active Active
-
2014
- 2014-02-27 US US14/192,633 patent/US20140186469A1/en not_active Abandoned
-
2015
- 2015-12-29 CY CY20151101197T patent/CY1117078T1/el unknown
-
2016
- 2016-01-07 HR HRP20160014TT patent/HRP20160014T1/hr unknown
-
2018
- 2018-06-06 AR ARP180101520A patent/AR112074A2/es unknown
-
2020
- 2020-11-06 NL NL301071C patent/NL301071I2/nl unknown
- 2020-11-16 NO NO2020037C patent/NO2020037I1/no unknown
- 2020-11-18 HU HUS2000044C patent/HUS2000044I1/hu unknown
- 2020-11-20 LU LU00186C patent/LUC00186I2/fr unknown
- 2020-11-24 CY CY2020037C patent/CY2020037I1/el unknown
- 2020-11-25 LT LTPA2020534C patent/LTC2331537I2/lt unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR112074A2 (es) | Derivados de 2-carboxamida-cicloamino-urea como inhibidores de pi-3 | |
| ECSP10010556A (es) | Piridinas y pirazinas como inhibidores de pi3k | |
| UY32062A (es) | Inhibidores de beta-secretasa | |
| SMT201300096B (it) | Inibitori di prolil idrossilasi | |
| DOP2011000204A (es) | Inhibidores de proteina cinasa | |
| PE20110062A1 (es) | N-(3-(3,5-dimetoxifenetil)-1h-pirazol-5-il)-4-(3,4-dimetilpiperazin-1-il)benzamida y sales del mismo | |
| MX2009008439A (es) | Nuevos inhibidores de la replicacion del virus de hepatitis c. | |
| EA201170520A1 (ru) | Ингибитор p38 mapk-киназы | |
| EA201071040A1 (ru) | Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1, cx3cr1 и p40 | |
| NO20084924L (no) | N-(2-thiazolyl)-amid derivater som GSK-3 inhibitorer | |
| MX2009002239A (es) | Derivados de 5-(2-furil)-1,3-tiazol util como inhibidores de fosfatidilinositol 3-cinasa. | |
| EA201100358A1 (ru) | Дабигатран для чрескожной хирургической катетеризации сердца | |
| MX2012004311A (es) | Derivados de ciclohexano spiro condensados como inhibidores de lipasa sensible a hormonas (hsl) utiles en el tratamiento de diabetes. | |
| NZ600310A (en) | 4-[2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine salts | |
| CR20120061A (es) | Tableta | |
| EA201171339A1 (ru) | Способ снижения внутриглазного давления у людей | |
| ECSP11010841A (es) | [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos | |
| CO6361993A2 (es) | Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina | |
| NO20085052L (no) | 4-((fluorofenoksyl)fenylmetyl)piperidin metansulfonat: anvendelser, synteseprosess og farmasoytiske sammensetninger | |
| DE602007011434D1 (de) | 1h-indol-5-ylpiperazin-1-ylmethanonderivate | |
| BR112012027813A2 (pt) | piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos | |
| EA201100502A1 (ru) | Гликозидные производные и их применения | |
| UY32852A (es) | [4-(5-aminometil-fenil)-piperidin-1-il]-1h-indol-3-il]-metanonas disustituidas. | |
| PE20120249A1 (es) | Compuestos etanaminicos | |
| MX2011007641A (es) | Nuevos compuestos heterociclicos como inhibidores de metap-2. |