BR112012027813A2 - piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos - Google Patents

piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos

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Publication number
BR112012027813A2
BR112012027813A2 BR112012027813A BR112012027813A BR112012027813A2 BR 112012027813 A2 BR112012027813 A2 BR 112012027813A2 BR 112012027813 A BR112012027813 A BR 112012027813A BR 112012027813 A BR112012027813 A BR 112012027813A BR 112012027813 A2 BR112012027813 A2 BR 112012027813A2
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Brazil
Prior art keywords
amino ethyl
acryloyl
piperazinotriazines
treatment
ethyl
Prior art date
Application number
BR112012027813A
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English (en)
Inventor
Giese Bernd
Wymann Mathias
Cmiljanovic Natasa
Cmiljanovic Vladimir
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Univ Of Basel
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Publication date
Application filed by Univ Of Basel filed Critical Univ Of Basel
Publication of BR112012027813A2 publication Critical patent/BR112012027813A2/pt

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Abstract

piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos. a invenção refere-se a compostos de fórmula (i), em que r1 é metila, n-hexila, amino etila, metil amino etila, etil amino etila, dimetil amino etila, acriloil amino etila, metacriloil amino etila, metoxietila, etoxietila, d-c4-alquil sulfonila, acriloíla, ou metacriloíla; ou r1 é amino etila, acriloíla, ou acriloil amino atila transportando um ligante e uma etiqueta, e r2 e r3, independentemente um do outro, são hidrogênio ou crc4-alquila, ou r2 e r3 juntos formam uma ponte metileno ou etileno; e seus tautômeros, solvatos e sais farmaceuticamente aceitáveis. estes compostos são eficazes na prevenção ou tratamento de uma doença ou distúrbio modulado por pi3 cinases e/ou mtor, em particular tratamento de um distúrbio hiperproliferativo.
BR112012027813A 2010-04-30 2011-04-27 piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos BR112012027813A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1007227.0A GB201007227D0 (en) 2010-04-30 2010-04-30 Piperazinotriazines
PCT/IB2011/051829 WO2011135520A1 (en) 2010-04-30 2011-04-27 Piperazinotriazines as pi3k inhibitors for use in the treatment antiproliferative disorders

Publications (1)

Publication Number Publication Date
BR112012027813A2 true BR112012027813A2 (pt) 2018-05-15

Family

ID=42289874

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012027813A BR112012027813A2 (pt) 2010-04-30 2011-04-27 piperazinotriazinas como inibidores de pi3k para uso no tratamento de distúrbios antiproliferativos

Country Status (16)

Country Link
US (1) US20130040912A1 (pt)
EP (1) EP2563368A1 (pt)
JP (1) JP2013525419A (pt)
KR (1) KR20130118731A (pt)
CN (1) CN103002899A (pt)
AU (1) AU2011246952A1 (pt)
BR (1) BR112012027813A2 (pt)
CA (1) CA2797808A1 (pt)
GB (1) GB201007227D0 (pt)
IL (1) IL222692A0 (pt)
MX (1) MX2012012560A (pt)
NZ (1) NZ603859A (pt)
RU (1) RU2012151201A (pt)
SG (1) SG185067A1 (pt)
WO (1) WO2011135520A1 (pt)
ZA (1) ZA201206898B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968345B1 (en) 2013-03-13 2017-12-13 The Regents of The University of Michigan Dual mek/pi3k inhibitors and their application in the treatment of cancer diseases
US9951040B2 (en) 2014-11-20 2018-04-24 Council Of Scientific And Industrial Research 1,3,5 -triazine based PI3K inhibitors as anticancer agents and a process for the preparation thereof
CN105130960B (zh) * 2015-07-31 2018-07-06 沈阳药科大学 1,3,5-三嗪类衍生物及其应用
CN109563088B (zh) 2016-07-06 2022-10-11 密歇根大学董事会 MEK/PI3K和mTOR/MEK/PI3K的多功能抑制剂和治疗用途
CN109810100B (zh) * 2017-11-21 2022-03-11 中国药科大学 含有苯并呋喃的parp-1和pi3k双靶点抑制剂
CN113200969B (zh) * 2021-05-19 2022-11-25 中国药科大学 一种PI3Kα选择性抑制剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1020462T3 (da) 1997-07-24 2004-04-26 Zenyaku Kogyo Kk Heterocykliske forbindelser og antitumormiddel indeholdende disse som aktiv ingrediens
DE60217322T2 (de) 2001-04-27 2007-10-04 Zenyaku Kogyo K.K. Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
JP2005531347A (ja) 2002-07-01 2005-10-20 アミジッチ，オグニエン 試験人物の認知または感覚運動の能力もしくは才能を評価するために使用されるデータを生成するための方法
CA2507100C (en) * 2002-11-21 2012-10-09 Chiron Corporation 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer
PT1864665E (pt) 2005-03-11 2012-06-27 Zenyaku Kogyo Kk Agente imunossupressor compreendendo um composto heterocíclico como ingrediente activo
WO2008032033A1 (en) 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
WO2009066084A1 (en) * 2007-11-21 2009-05-28 F. Hoffmann-La Roche Ag 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
EP2276750A2 (en) * 2008-03-27 2011-01-26 Auckland Uniservices Limited Substituted pyrimidines and triazines and their use in cancer therapy
US8513221B2 (en) * 2008-07-07 2013-08-20 Xcovery Holding, LLC PI3K isoform selective inhibitors
US8461158B2 (en) * 2009-03-27 2013-06-11 Pathway Therapeutics Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy

Also Published As

Publication number Publication date
ZA201206898B (en) 2013-07-31
GB201007227D0 (en) 2010-06-16
IL222692A0 (en) 2012-12-31
RU2012151201A (ru) 2014-06-10
US20130040912A1 (en) 2013-02-14
WO2011135520A8 (en) 2012-09-27
CN103002899A (zh) 2013-03-27
MX2012012560A (es) 2012-12-17
AU2011246952A1 (en) 2012-12-20
JP2013525419A (ja) 2013-06-20
SG185067A1 (en) 2012-12-28
KR20130118731A (ko) 2013-10-30
CA2797808A1 (en) 2011-11-03
EP2563368A1 (en) 2013-03-06
WO2011135520A1 (en) 2011-11-03
NZ603859A (en) 2014-07-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2472 DE 22-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.