MXPA04001399A - Derivados de tiazolilo 2-amino-4,5-trisustituidos. - Google Patents

Derivados de tiazolilo 2-amino-4,5-trisustituidos.

Info

Publication number
MXPA04001399A
MXPA04001399A MXPA04001399A MXPA04001399A MXPA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A
Authority
MX
Mexico
Prior art keywords
amino
6alkyl
aminocarbonyl
mono
optionally substituted
Prior art date
Application number
MXPA04001399A
Other languages
English (en)
Inventor
Paul Cooymans Ludwig
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04001399A publication Critical patent/MXPA04001399A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invencion se relaciona con el uso de un compuesto de formula (l'°), un N-oxido, una sal de adicion farmaceuticamente aceptable, una amina cuaternaria y una forma estereoquimicamente isomerica del mismo, en donde Z es halo; alquilo de C1-6; alquilcarbonilo de C1-6; alquiloxicarbonilo de C1-6; aminocarbonilo; alquilo de C1-6 sustituido con hidroxi, carboxilo, ciano, amino, amino sustituido con piperidinilo, amino sustituido con piperidinilo sustituido con alquilo de C1-4, mono o di(alquil de C1-6)amino, aminocarbonilo, mono o di(alquil de C1-6)aminocarbonilo, alquiloxicarbonilo d e C1-6, alquiloxi de C1-6, piperidinilo, piperacinilo, motfoIinilo, tiomorioIinilo; polihaloalquilo de C1-4; ciano; amino; mono o di(alquil de C1-6)aminocarbonilo; alquiloxicarbonilo de C1-6; alquilcarboniloxi de C1-6; amino-S(=O)2-; mono o di(alquil de C1-6)amino- S(=O)2; -C(=N-Rx)NRyRZ; Q es cicloalquilo de C3-6, fenilo, piridilo, pirimidinilo, piracinilo, piridacinilo, benztiazolilo, benzoxazolilo, bencimidazolilo, indazolilo, o imidazopiridilo sustituido opcionalmente, o Q es un radical de la formula (b- 1), (b-2), o (b-3), L es fenilo sustituido opcionalmente o un heterociclo monociclico de 5 o 6 miembros parcialmente saturado o aromatico, o un heterociclo biciclico parcialmente saturado o aromatico, sustituido opcionalmente; arilo es fenilo sustituido opcionalmente; para la fabricacion de un medicamento para la prevencion o el tratamiento de enfermedades inflamatorias y/o autoinmunes, mediadas a traves del TNF-a y/o la IL-12.
MXPA04001399A 2001-08-13 2002-08-09 Derivados de tiazolilo 2-amino-4,5-trisustituidos. MXPA04001399A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203087 2001-08-13
PCT/EP2002/008955 WO2003015773A2 (en) 2001-08-13 2002-08-09 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases

Publications (1)

Publication Number Publication Date
MXPA04001399A true MXPA04001399A (es) 2004-05-27

Family

ID=8180790

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001399A MXPA04001399A (es) 2001-08-13 2002-08-09 Derivados de tiazolilo 2-amino-4,5-trisustituidos.

Country Status (21)

Country Link
US (2) US7232838B2 (es)
EP (1) EP1418909B1 (es)
JP (1) JP4388805B2 (es)
KR (2) KR100979988B1 (es)
CN (1) CN100496493C (es)
AU (1) AU2002324045C1 (es)
BR (1) BR0211887A (es)
CA (1) CA2451980C (es)
EA (1) EA007717B1 (es)
ES (1) ES2407807T3 (es)
HK (1) HK1069997A1 (es)
HR (1) HRP20040097B1 (es)
HU (1) HUP0401748A3 (es)
IL (2) IL160329A0 (es)
MX (1) MXPA04001399A (es)
NO (1) NO327409B1 (es)
NZ (1) NZ530950A (es)
PL (1) PL368130A1 (es)
UA (1) UA82176C2 (es)
WO (1) WO2003015773A2 (es)
ZA (1) ZA200401162B (es)

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AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
BRPI0507271A (pt) * 2004-01-30 2007-06-26 Ab Science 2-(3-substituìda-aril)amino-4-aril-tiazóis como inibidores de tirosina cinase
EP1879575A2 (en) * 2005-05-09 2008-01-23 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
WO2006128172A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating b cell regulated autoimmune disorders
EP1926719B1 (en) * 2005-09-13 2017-05-31 Janssen Pharmaceutica NV 2-aniline-4-aryl substituted thiazole derivatives
CN101484433A (zh) 2006-02-15 2009-07-15 艾博特公司 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
JP2009526868A (ja) * 2006-02-15 2009-07-23 アボット・ラボラトリーズ 新規なアセチル−ＣｏＡカルボキシラーゼ（ＡＣＣ）阻害薬およびこれらの糖尿病、肥満および代謝症候群における使用
CA2645072A1 (en) * 2006-03-08 2007-09-13 Achillion Pharmaceuticals, Inc. Substituted aminothiazole derivatives with anti-hcv activity
ES2589736T3 (es) 2006-03-31 2016-11-16 Novartis Ag Derivados de piridina como inhibidores de DGAT
CN101801964A (zh) * 2007-05-22 2010-08-11 艾其林医药公司 杂芳基取代的噻唑及其作为抗病毒剂的用途
CA2693162C (en) * 2007-07-17 2017-05-16 Acea Biosciences Inc. Heterocyclic compounds and uses as anticancer agents
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
RU2474579C2 (ru) 2007-10-18 2013-02-10 Янссен Фармацевтика Нв Тризамещенные 1,2,4-триазолы
PA8809001A1 (es) 2007-12-20 2009-07-23 Novartis Ag Compuestos organicos
WO2009114552A1 (en) * 2008-03-10 2009-09-17 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl compounds, compositions, and methods of use in cancer treatment
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
US8106209B2 (en) * 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
ES2605815T3 (es) * 2008-07-01 2017-03-16 Ptc Therapeutics, Inc. Moduladores de la expresión de la proteína Bmi-1
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
TW201026693A (en) * 2008-10-01 2010-07-16 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
JP6240078B2 (ja) * 2011-10-04 2017-11-29 バルーク エス．ブルームバーグ インスティテュート 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール
CN103159695B (zh) * 2011-12-08 2015-08-12 首都师范大学 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
WO2003015773A2 (en) 2003-02-27
US20040254191A1 (en) 2004-12-16
EP1418909A2 (en) 2004-05-19
HK1069997A1 (en) 2005-06-10
IL160329A0 (en) 2004-07-25
US20070203189A1 (en) 2007-08-30
BR0211887A (pt) 2004-09-21
EA200400306A1 (ru) 2004-08-26
HRP20040097A2 (en) 2004-06-30
CN1541097A (zh) 2004-10-27
ES2407807T3 (es) 2013-06-14
HUP0401748A2 (hu) 2004-12-28
KR20040031712A (ko) 2004-04-13
JP2005501099A (ja) 2005-01-13
AU2002324045B2 (en) 2007-10-04
EA007717B1 (ru) 2006-12-29
CA2451980C (en) 2012-12-11
UA82176C2 (en) 2008-03-25
ZA200401162B (en) 2005-07-27
PL368130A1 (en) 2005-03-21
NO20040632L (no) 2004-03-11
KR20100076043A (ko) 2010-07-05
US7232838B2 (en) 2007-06-19
JP4388805B2 (ja) 2009-12-24
CN100496493C (zh) 2009-06-10
US7803823B2 (en) 2010-09-28
KR100979988B1 (ko) 2010-09-03
NO327409B1 (no) 2009-06-22
NZ530950A (en) 2006-03-31
HRP20040097B1 (hr) 2013-10-11
AU2002324045C1 (en) 2008-05-29
CA2451980A1 (en) 2003-02-27
HUP0401748A3 (en) 2011-03-28
IL160329A (en) 2010-05-31
KR101034489B1 (ko) 2011-05-17
EP1418909B1 (en) 2013-02-20
WO2003015773A3 (en) 2003-12-18

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