NO20040632L - 2-amino-4,5-trisubstituerte tiazolylderivater. - Google Patents

2-amino-4,5-trisubstituerte tiazolylderivater.

Info

Publication number
NO20040632L
NO20040632L NO20040632A NO20040632A NO20040632L NO 20040632 L NO20040632 L NO 20040632L NO 20040632 A NO20040632 A NO 20040632A NO 20040632 A NO20040632 A NO 20040632A NO 20040632 L NO20040632 L NO 20040632L
Authority
NO
Norway
Prior art keywords
amino
thiazolyl derivatives
trisubstituted
trisubstituted thiazolyl
derivatives
Prior art date
Application number
NO20040632A
Other languages
English (en)
Other versions
NO327409B1 (no
Inventor
Ludwig Paul Cooymans
Robert Jozef Maria Hendrickx
Guy Rosalia Eugene Van Lommen
Gustaaf Maria Boeckx
Erwin Coesemans
Christopher John Love
Nele Vandermaesen
Julien Georges Pierre-Ol Doyon
Jean-Pierre Andre Ma Bongaritz
Marcel Jozef Maria Van Der Aa
Peter Jacobus Johan Buijnsters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20040632L publication Critical patent/NO20040632L/no
Publication of NO327409B1 publication Critical patent/NO327409B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
NO20040632A 2001-08-13 2004-02-12 2-amino-4,5-trisubstituerte tiazolylderivater. NO327409B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203087 2001-08-13
PCT/EP2002/008955 WO2003015773A2 (en) 2001-08-13 2002-08-09 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases

Publications (2)

Publication Number Publication Date
NO20040632L true NO20040632L (no) 2004-03-11
NO327409B1 NO327409B1 (no) 2009-06-22

Family

ID=8180790

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040632A NO327409B1 (no) 2001-08-13 2004-02-12 2-amino-4,5-trisubstituerte tiazolylderivater.

Country Status (21)

Country Link
US (2) US7232838B2 (no)
EP (1) EP1418909B1 (no)
JP (1) JP4388805B2 (no)
KR (2) KR100979988B1 (no)
CN (1) CN100496493C (no)
AU (1) AU2002324045C1 (no)
BR (1) BR0211887A (no)
CA (1) CA2451980C (no)
EA (1) EA007717B1 (no)
ES (1) ES2407807T3 (no)
HK (1) HK1069997A1 (no)
HR (1) HRP20040097B1 (no)
HU (1) HUP0401748A3 (no)
IL (2) IL160329A0 (no)
MX (1) MXPA04001399A (no)
NO (1) NO327409B1 (no)
NZ (1) NZ530950A (no)
PL (1) PL368130A1 (no)
UA (1) UA82176C2 (no)
WO (1) WO2003015773A2 (no)
ZA (1) ZA200401162B (no)

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JP3836019B2 (ja) * 2001-11-21 2006-10-18 松下電器産業株式会社 受信装置、送信装置及び送信方法
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
NZ548884A (en) * 2004-01-30 2010-06-25 Ab Science 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors
UA92746C2 (en) 2005-05-09 2010-12-10 Акилайон Фармасьютикалз, Инк. Thiazole compounds and methods of use
US20070032493A1 (en) * 2005-05-26 2007-02-08 Synta Pharmaceuticals Corp. Method for treating B cell regulated autoimmune disorders
EP1926719B1 (en) * 2005-09-13 2017-05-31 Janssen Pharmaceutica NV 2-aniline-4-aryl substituted thiazole derivatives
CN101384568B (zh) * 2006-02-15 2012-12-12 雅培制药有限公司 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
CN101484433A (zh) 2006-02-15 2009-07-15 艾博特公司 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
EP1996565A2 (en) * 2006-03-08 2008-12-03 Achillion Pharmaceuticals, Inc. Substituted aminothiazole derivatives with anti-hcv activity
ES2649564T3 (es) 2006-03-31 2018-01-12 Novartis Ag Inhibidores de DGAT
BRPI0811939A2 (pt) 2007-05-22 2014-11-25 Achillion Pharmaceuticals Inc Tiazóis substituídos por heteroarila
ES2617305T3 (es) * 2007-07-17 2017-06-16 Acea Biosciences, Inc. Compuestos heterocíclicos y usos como agentes anticancerosos
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
MX2010004177A (es) 2007-10-18 2010-05-03 Janssen Pharmaceutica Nv 1,2,4-triazoles trisustituidos.
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
AR069798A1 (es) 2007-12-20 2010-02-17 Novartis Ag Derivados de 1, 3-tiazol, metodos para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la manufactura de medicamentos para el tratamiento de enfermedades mediadas por la fosfatidilinositol 3-cinasa.
WO2009114552A1 (en) * 2008-03-10 2009-09-17 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl compounds, compositions, and methods of use in cancer treatment
CN102066343B (zh) 2008-03-19 2013-12-04 詹森药业有限公司 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类
ES2525132T3 (es) 2008-05-09 2014-12-17 Janssen Pharmaceutica, N.V. Pirazoles trisustituidos como moduladores de los receptores de acetilcolina
US8106209B2 (en) * 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
WO2010002985A1 (en) * 2008-07-01 2010-01-07 Ptc Therapeutics, Inc. Bmi-1 protein expression modulators
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
TW201026693A (en) * 2008-10-01 2010-07-16 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
BR112014007963A2 (pt) * 2011-10-04 2013-04-11 Inst For Hepatitis And Virus Res aminotiazoles substituídos como inibidores de cãncer, incluindo carcinoma hepatocelular, e como inibidores da replicação do vírus da hepatite
CN103159695B (zh) * 2011-12-08 2015-08-12 首都师范大学 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途
CN102863435B (zh) * 2012-09-25 2015-02-18 盐城工学院 一种2-[[4-氟-3-(三氟甲基)苯基]氨基]-4-吡啶基-5-噻唑甲醛及其还原产物的制备方法
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
CN107531687A (zh) * 2015-02-27 2018-01-02 加利福尼亚大学董事会 能够实现软骨复壮的小分子
KR20170001969U (ko) 2015-11-27 2017-06-07 주식회사 바이오해저드특수청소 조류 퇴치기
CN105524056A (zh) * 2016-01-05 2016-04-27 中山大学肿瘤防治中心 一种氨基噻唑化合物及其制备方法和应用

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US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
BE795907A (fr) * 1972-02-25 1973-06-18 Luso Farmaco Inst 2-amino-4-arylthiazoles 5-substitues et leur preparation
US4649146A (en) * 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same
DE3486009T2 (de) * 1983-09-09 1993-04-15 Takeda Chemical Industries Ltd 5-pyridyl-1,3-thiazol-derivate, ihre herstellung und anwendung.
DE3406232A1 (de) 1984-02-21 1985-08-29 Bayer Ag, 5090 Leverkusen Faserreaktive formazanfarbstoffe
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
JPS6267022A (ja) 1985-09-18 1987-03-26 Otsuka Pharmaceut Factory Inc 抗炎症剤
US5000775A (en) * 1985-12-31 1991-03-19 Monsanto Company 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes
JPH07149745A (ja) 1993-11-30 1995-06-13 Hisamitsu Pharmaceut Co Inc 新規な２−アミノチアゾール誘導体
AU689972B2 (en) * 1994-11-29 1998-04-09 Hisamitsu Pharmaceutical Co., Inc. Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
CZ154398A3 (cs) 1995-11-23 1998-08-12 Janssen Pharmaceutica N.V. Pevné směsi cyklodextrinů připravené vytlačováním taveniny
AU4506399A (en) 1998-06-05 1999-12-30 Novartis Ag Aryl pyridinyl thiazoles
AU3740101A (en) 2000-03-01 2001-09-12 Janssen Pharmaceutica Nv 2,4-disubstituted thiazolyl derivatives
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
AU2001295992A1 (en) 2000-10-24 2002-05-06 Sankyo Company Limited Imidazopyridine derivatives

Also Published As

Publication number Publication date
CN1541097A (zh) 2004-10-27
BR0211887A (pt) 2004-09-21
CA2451980A1 (en) 2003-02-27
EA007717B1 (ru) 2006-12-29
US7232838B2 (en) 2007-06-19
HUP0401748A3 (en) 2011-03-28
CA2451980C (en) 2012-12-11
US20070203189A1 (en) 2007-08-30
JP2005501099A (ja) 2005-01-13
ZA200401162B (en) 2005-07-27
MXPA04001399A (es) 2004-05-27
UA82176C2 (en) 2008-03-25
AU2002324045C1 (en) 2008-05-29
PL368130A1 (en) 2005-03-21
WO2003015773A3 (en) 2003-12-18
EP1418909A2 (en) 2004-05-19
CN100496493C (zh) 2009-06-10
HRP20040097A2 (en) 2004-06-30
KR101034489B1 (ko) 2011-05-17
KR20040031712A (ko) 2004-04-13
US7803823B2 (en) 2010-09-28
ES2407807T3 (es) 2013-06-14
HRP20040097B1 (hr) 2013-10-11
US20040254191A1 (en) 2004-12-16
IL160329A0 (en) 2004-07-25
NO327409B1 (no) 2009-06-22
HK1069997A1 (en) 2005-06-10
EA200400306A1 (ru) 2004-08-26
NZ530950A (en) 2006-03-31
KR100979988B1 (ko) 2010-09-03
IL160329A (en) 2010-05-31
JP4388805B2 (ja) 2009-12-24
EP1418909B1 (en) 2013-02-20
AU2002324045B2 (en) 2007-10-04
KR20100076043A (ko) 2010-07-05
WO2003015773A2 (en) 2003-02-27
HUP0401748A2 (hu) 2004-12-28

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