EA200400306A1 - 2-амино-4,5-тризамещенные производные тиазолила - Google Patents

2-амино-4,5-тризамещенные производные тиазолила

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Publication number
EA200400306A1
EA200400306A1 EA200400306A EA200400306A EA200400306A1 EA 200400306 A1 EA200400306 A1 EA 200400306A1 EA 200400306 A EA200400306 A EA 200400306A EA 200400306 A EA200400306 A EA 200400306A EA 200400306 A1 EA200400306 A1 EA 200400306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
alkyl
aminocarbonyl
mono
optionally substituted
Prior art date
Application number
EA200400306A
Other languages
English (en)
Other versions
EA007717B1 (ru
Inventor
Кристофер Джон Лав
Ги Розалия Эген Ван Ломмен
Жюльен Жорж Пьер-Оливье Дойон
Жан-Пьер Андре Марк Бонгартз
Марсель Йозеф Мария Ван Дер Аа
Роберт Йозеф Мария Хендрикс
Петер Якобус Йоханнес Антониус Бейнстерс
Людвиг Поль Коиманс
Неле Вандермасен
Эрвин Кусеманс
Густаф Мария Букс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200400306A1 publication Critical patent/EA200400306A1/ru
Publication of EA007717B1 publication Critical patent/EA007717B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Изобретение относится к применению соединения формулы (I'), его N-оксида, фармацевтически приемлемой аддитивной соли, четвертичного амина и стереохимически изомерной формы, где Z представляет собой галоген; Cалкил; Cалкилкарбонил; Cалкилоксикарбонил; аминокарбонил; Cалкил, замещенный гидрокси, карбоксилом, циано, амино, амино, замещенным пиперидинилом, амино, замещенным Cалкилом, замещенным пиперидинилом, моно- или ди(Cалкил)амино, аминокарбонилом, моно- или ди(Cалкил)аминокарбонилом, Cалкилоксикарбонилом, Cалкилокси, пиперидинилом, пиперазинилом, морфолинилом, тиоморфолинилом; полигалоген-Cалкил; циано; амино; моно- или ди(Cалкил)аминокарбонил; Cалкилоксикарбонил; Cалкилкарбонилокси; амино-S(=O)-; моно- или ди(Cалкил)амино-S(=O)или -C(=N-R)NRR; Q представляет собой необязательно замещенный Cциклоалкил, фенил, пиридил, пиримидинил, пиразинил, пиридазинил, бензтиазолил, бензоксазолил, бензимидазолил, индазолил или имидазопиридил или Q представляет собой радикал формул (b-1), (b-2) или (b-3), L представляет собой необязательно замещенный фенил или необязательно замещенный моноциклический 5- или 6-членный частично насыщенный или ароматический гетероцикл или бициклический частично насыщенный или ароматический гетероцикл; арил представляет собой необязательно замещенный фенил, для изготовления лекарственного средства для предотвращения или лечения воспалительных или аутоиммунных заболеваний, опосредованных TNF-α и/или IL-12.Отчет о международном поиске был опубликован 2003.12.18.
EA200400306A 2001-08-13 2002-08-09 2-амино-4,5-тризамещенные производные тиазолила EA007717B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203087 2001-08-13
PCT/EP2002/008955 WO2003015773A2 (en) 2001-08-13 2002-08-09 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases

Publications (2)

Publication Number Publication Date
EA200400306A1 true EA200400306A1 (ru) 2004-08-26
EA007717B1 EA007717B1 (ru) 2006-12-29

Family

ID=8180790

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400306A EA007717B1 (ru) 2001-08-13 2002-08-09 2-амино-4,5-тризамещенные производные тиазолила

Country Status (21)

Country Link
US (2) US7232838B2 (ru)
EP (1) EP1418909B1 (ru)
JP (1) JP4388805B2 (ru)
KR (2) KR101034489B1 (ru)
CN (1) CN100496493C (ru)
AU (1) AU2002324045C1 (ru)
BR (1) BR0211887A (ru)
CA (1) CA2451980C (ru)
EA (1) EA007717B1 (ru)
ES (1) ES2407807T3 (ru)
HK (1) HK1069997A1 (ru)
HR (1) HRP20040097B1 (ru)
HU (1) HUP0401748A3 (ru)
IL (2) IL160329A0 (ru)
MX (1) MXPA04001399A (ru)
NO (1) NO327409B1 (ru)
NZ (1) NZ530950A (ru)
PL (1) PL368130A1 (ru)
UA (1) UA82176C2 (ru)
WO (1) WO2003015773A2 (ru)
ZA (1) ZA200401162B (ru)

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JP6240078B2 (ja) 2011-10-04 2017-11-29 バルーク エス．ブルームバーグ インスティテュート 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール
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Also Published As

Publication number Publication date
CN1541097A (zh) 2004-10-27
JP2005501099A (ja) 2005-01-13
JP4388805B2 (ja) 2009-12-24
CA2451980A1 (en) 2003-02-27
KR100979988B1 (ko) 2010-09-03
AU2002324045C1 (en) 2008-05-29
IL160329A (en) 2010-05-31
EP1418909A2 (en) 2004-05-19
AU2002324045B2 (en) 2007-10-04
HRP20040097A2 (en) 2004-06-30
EP1418909B1 (en) 2013-02-20
KR20040031712A (ko) 2004-04-13
NO20040632L (no) 2004-03-11
HUP0401748A3 (en) 2011-03-28
HRP20040097B1 (hr) 2013-10-11
WO2003015773A3 (en) 2003-12-18
EA007717B1 (ru) 2006-12-29
NO327409B1 (no) 2009-06-22
CN100496493C (zh) 2009-06-10
UA82176C2 (en) 2008-03-25
US20070203189A1 (en) 2007-08-30
ZA200401162B (en) 2005-07-27
IL160329A0 (en) 2004-07-25
KR20100076043A (ko) 2010-07-05
BR0211887A (pt) 2004-09-21
US7803823B2 (en) 2010-09-28
HK1069997A1 (en) 2005-06-10
CA2451980C (en) 2012-12-11
ES2407807T3 (es) 2013-06-14
PL368130A1 (en) 2005-03-21
MXPA04001399A (es) 2004-05-27
US20040254191A1 (en) 2004-12-16
HUP0401748A2 (hu) 2004-12-28
NZ530950A (en) 2006-03-31
KR101034489B1 (ko) 2011-05-17
WO2003015773A2 (en) 2003-02-27
US7232838B2 (en) 2007-06-19

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