AR037506A1 - Compuestos derivados de 4-fenil-4-[1h-imidazol-2-il]piperidina sustituida, sus profarmacos, composiciones farmaceuticas que comprenden dichos compuestos derivados, y uso de dichos compuestos derivados o composiciones farmaceuticas para la elaboracion de medicamentos - Google Patents
Compuestos derivados de 4-fenil-4-[1h-imidazol-2-il]piperidina sustituida, sus profarmacos, composiciones farmaceuticas que comprenden dichos compuestos derivados, y uso de dichos compuestos derivados o composiciones farmaceuticas para la elaboracion de medicamentosInfo
- Publication number
- AR037506A1 AR037506A1 ARP020103837A ARP020103837A AR037506A1 AR 037506 A1 AR037506 A1 AR 037506A1 AR P020103837 A ARP020103837 A AR P020103837A AR P020103837 A ARP020103837 A AR P020103837A AR 037506 A1 AR037506 A1 AR 037506A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- group
- carbon atoms
- alkyloxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina sustituida de fórmula (1), las sales de adición de ácido o base farmacéuticamente aceptables de los mismos, las formas estereoquímicamente isómericas de los mismos, las formas tautoméricas de los mismos, y las formas N-óxido de los mismos, en donde: A=B es un radical con enlace p bivalente; X es un enlace covalente, -CH2- o CH2CH2-; R1 es hidrógeno, alquiloxi, alquilcarboniloxi, Ar-oxi, Het-oxi, Ar-carboniloxi, Het-carboniloxi, Ar-alquiloxi, Het-alquiloxi, alquilo, polihaloalquilo, alquiloxialquilo, Ar-alquilo, Het-alquilo, Ar, Het, tio, alquiltio, Ar-tio, Het-tio o NR9R10 donde cada uno de R9 y R10 es independientemente hidrógeno, alquilo, Ar, Ar-alquilo, Het, Het-alquilo, alquil-carbonilo, Ar-carbonilo, Het-carbonilo o alquiloxicarbonilalquilo; o bien A=B y R1 juntos, forman un radical Het2 o Het3 carbocíclico o heterocíclico semiaromático o aromático optativamente sustituido; R2 es hidroxi, alquiloxi, alquilcarboniloxi, feniloxi, fenilcarboniloxi, halo, ciano, alquilo, polihaloalquilo, alquiloxialquilo, formilo, carboxi, alquilcarbonilo, alquiloxicarbonilo, aminocarbonilo, mono- o dialquilaminocarbonilo, fenilo, nitro, amino, mono- o dialquilamino, tio o alquiltio; R3 es alquilo, Ar, Ar-alquilo, Ar-alquenilo, Het, Het-alquilo o Het-alquenilo; R4, R5 es independientemente en cada caso hidrógeno, alquilo, carboxi, aminocarbonilo, alquiloxicarbonilo, halo o hidroxialquilo; P es un entero igual a cero, 1, 2 o 3; alquilo es un radical hidrocarburo saturado recto o ramificado con 1 a 6 átomos de carbono o es un radical hidrocarburo saturado cíclico (cicloalquilo) con 3 a 7 átomos de carbono, o es un radical hidrocarburo saturado cíclico con 3 a 7 átomos de carbono adherido a un radical hidrocarburo saturado recto o ramificado con 1 a 6 átomos de carbono, donde cada átomo de carbono puede estar optativamente sustituido con amino, nitro, tio, hidroxi, oxo, ciano, formilo o carboxi; alquenilo es un radical alquilo con uno o más enlaces dobles; Ar es un homociclo seleccionado entre el grupo que consiste en fenilo y naftilo, cada uno de los cuales está optativamente sustituido con uno o más sustituyentes, donde cada sustituyente es independientemente seleccionado entre el grupo que consiste en hidroxi, alquiloxi, feniloxi, fenilcarboniloxi, polihaloalquiloxi, halo, ciano, alquilo, polihaloalquilo, alquiloxialquilo, formilo, haloformilo, carboxi, alquilcarbonilo, alquiloxicarbonilo, aminocarbonilo, mono- o dialquilaminocarbonilo, fenilalquilo, fenilo, nitro, amino, mono- o dialquilamino, tio, alquiltio o SO2-CH3; halo es un sustituyente seleccionado entre el grupo que consiste en flúor, cloro, bromo y yodo; polihaloalquilo es un radical hidrocarburo recto o ramificado con 1 a 6 átomos de carbono o un radical hidrocarburo saturado cíclico con 3 a 7 átomos de carbono, donde uno o más de los átomos de carbono está sustituido con uno o más átomos de halógeno; Het es un radical heterocíclico seleccionado entre el grupo que consiste en Het1, Het2 y Het3; Het1 es un radical heterocíclico monocíclico alifático seleccionado entre el grupo que consiste en pirrolidinilo, dioxolilo, imidazolidinilo, pirazolidinilo, piperidinilo, dioxilo, morfolinilo, ditienilo, tiomorfolinilo, piperazinilo y tetrahidrofuranilo; Het2 es un radical heterocíclico monocíclico semiaromático seleccionado entre el grupo que consiste en 2H-pirrolilo, pirrolinilo, imidazolinilo y pirazolinilo; Het3 es un radical heterocíclico monocíclico aromático seleccionado entre el grupo que consiste en pirrolilo, pirazolilo, imidazolilo, furanilo, tienilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, piridinilo, pirimidinilo, pirazinilo, piridazinilo y triazinilo; o un radical heterocíclico bicíclico aromático seleccionado entre el grupo que consiste en quinolinilo, quinoxalinilo, indolilo, bencimidazolilo, benzoxazolilo, bencisoxazolilo, benzotiazolilo, bencisotiazolilo, benzofuranilo y benzotienilo; cada radical heterocíclico monocíclico y bicíclico puede estar optativamente sustituido en un carbono y/o un heteroátomo con halo, hidroxi, alquiloxi, alquilo, Ar, Ar-alquilo o piridinilo. Dichos compuestos son agonistas selectivos no peptídicos de opioides para uso en el tratamiento de diversos trastornos dolorosos. También se dan a conocer: sus profármacos, composiciones farmacéuticas que comprenden dichos compuestos derivados, y el uso de dichos compuestos derivados o composiciones farmacéuticas para la elaboración de medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203926 | 2001-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037506A1 true AR037506A1 (es) | 2004-11-17 |
Family
ID=8181080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103837A AR037506A1 (es) | 2001-10-15 | 2002-10-11 | Compuestos derivados de 4-fenil-4-[1h-imidazol-2-il]piperidina sustituida, sus profarmacos, composiciones farmaceuticas que comprenden dichos compuestos derivados, y uso de dichos compuestos derivados o composiciones farmaceuticas para la elaboracion de medicamentos |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7282508B2 (es) |
| EP (1) | EP1438304B1 (es) |
| JP (1) | JP4417108B2 (es) |
| KR (1) | KR100898562B1 (es) |
| CN (1) | CN100354273C (es) |
| AR (1) | AR037506A1 (es) |
| AT (1) | ATE347549T1 (es) |
| AU (1) | AU2002346994B2 (es) |
| BR (1) | BR0213327A (es) |
| CA (1) | CA2462953C (es) |
| CY (1) | CY1106356T1 (es) |
| DE (1) | DE60216627T2 (es) |
| EA (1) | EA006507B1 (es) |
| ES (1) | ES2278065T3 (es) |
| HR (1) | HRP20040324A2 (es) |
| HU (1) | HUP0600447A3 (es) |
| IL (2) | IL161348A0 (es) |
| MX (1) | MXPA04003479A (es) |
| MY (1) | MY137356A (es) |
| NO (1) | NO327602B1 (es) |
| NZ (1) | NZ531679A (es) |
| PL (1) | PL367967A1 (es) |
| PT (1) | PT1438304E (es) |
| UA (1) | UA76224C2 (es) |
| WO (1) | WO2003033486A1 (es) |
| ZA (1) | ZA200402818B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4418676B2 (ja) * | 2001-10-15 | 2010-02-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 虚血性損傷を減らすための置換された４−フェニル−４−（１ｈ−イミダゾール−２−イル）−ピペリジン誘導体 |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| US6982268B2 (en) | 2002-05-08 | 2006-01-03 | Neurogen Corporation | Substituted imidazolylmethyl pyridine and pyrazine derivatives GABAA receptor ligands |
| DE60330794D1 (de) * | 2002-07-03 | 2010-02-11 | Glaxo Group Ltd | Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer |
| AR044010A1 (es) * | 2003-04-11 | 2005-08-24 | Janssen Pharmaceutica Nv | Uso de derivados de 4-fenil-4- [1h-imidazol-2-il]- piperidina sustituidos como agonistas delta opioideos no peptidos selectivos, con actividad antidepresiva y ansiolitica |
| CA2541014A1 (en) | 2003-10-01 | 2005-04-14 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| AU2013205089B2 (en) * | 2004-03-15 | 2013-12-19 | Janssen Pharmaceutica, N.V. | Novel compounds as opioid receptor modulators |
| KR101166342B1 (ko) * | 2004-03-15 | 2012-07-18 | 얀센 파마슈티카 엔.브이. | 아편계 약물 수용체 조절자로서의 신규의 화합물 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| AU2007294968A1 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| TWI652264B (zh) * | 2013-09-26 | 2019-03-01 | 東麗股份有限公司 | Cyclic amine derivatives and their medical uses |
| WO2019079578A1 (en) | 2017-10-19 | 2019-04-25 | Amgen Inc. | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2985322B2 (ja) | 1991-03-01 | 1999-11-29 | 東レ株式会社 | イソキノリン誘導体およびその医薬用途 |
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| JPH09505030A (ja) | 1993-08-06 | 1997-05-20 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | ヒドロイソキノリン誘導体 |
| US5618934A (en) | 1994-05-17 | 1997-04-08 | Merck & Co., Inc. | Boronic acid compound |
| AU4458996A (en) | 1995-01-20 | 1996-08-07 | Nippon Shinyaku Co. Ltd. | Ethylamine derivatives and drugs |
| IT1307327B1 (it) | 1995-09-12 | 2001-10-30 | Smithkline Beecham Spa | Derivati idroisochinolinici sostituiti |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| DE19805370A1 (de) | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| GB9709972D0 (en) | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| WO2000037470A1 (en) * | 1998-12-19 | 2000-06-29 | Janssen Pharmaceutica N.V. | Antihistaminic spiro compounds |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| JP2005231995A (ja) | 1999-12-22 | 2005-09-02 | Meiji Seika Kaisha Ltd | オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物 |
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2002
- 2002-10-10 EA EA200400545A patent/EA006507B1/ru not_active IP Right Cessation
- 2002-10-10 AU AU2002346994A patent/AU2002346994B2/en not_active Ceased
- 2002-10-10 UA UA20040503667A patent/UA76224C2/uk unknown
- 2002-10-10 KR KR1020047002381A patent/KR100898562B1/ko not_active IP Right Cessation
- 2002-10-10 NZ NZ531679A patent/NZ531679A/en not_active IP Right Cessation
- 2002-10-10 PL PL02367967A patent/PL367967A1/xx unknown
- 2002-10-10 EP EP02782881A patent/EP1438304B1/en not_active Expired - Lifetime
- 2002-10-10 CN CNB028203275A patent/CN100354273C/zh not_active Expired - Fee Related
- 2002-10-10 WO PCT/EP2002/011372 patent/WO2003033486A1/en active IP Right Grant
- 2002-10-10 HU HU0600447A patent/HUP0600447A3/hu unknown
- 2002-10-10 US US10/491,379 patent/US7282508B2/en not_active Expired - Fee Related
- 2002-10-10 MX MXPA04003479A patent/MXPA04003479A/es active IP Right Grant
- 2002-10-10 CA CA2462953A patent/CA2462953C/en not_active Expired - Lifetime
- 2002-10-10 JP JP2003536226A patent/JP4417108B2/ja not_active Expired - Fee Related
- 2002-10-10 ES ES02782881T patent/ES2278065T3/es not_active Expired - Lifetime
- 2002-10-10 AT AT02782881T patent/ATE347549T1/de active
- 2002-10-10 DE DE60216627T patent/DE60216627T2/de not_active Expired - Lifetime
- 2002-10-10 BR BR0213327-0A patent/BR0213327A/pt not_active IP Right Cessation
- 2002-10-10 PT PT02782881T patent/PT1438304E/pt unknown
- 2002-10-10 IL IL16134802A patent/IL161348A0/xx unknown
- 2002-10-11 AR ARP020103837A patent/AR037506A1/es unknown
- 2002-10-11 MY MYPI20023800A patent/MY137356A/en unknown
-
2004
- 2004-04-06 HR HR20040324A patent/HRP20040324A2/xx not_active Application Discontinuation
- 2004-04-13 IL IL161348A patent/IL161348A/en not_active IP Right Cessation
- 2004-04-13 ZA ZA2004/02818A patent/ZA200402818B/en unknown
- 2004-04-22 NO NO20041666A patent/NO327602B1/no not_active IP Right Cessation
-
2007
- 2007-03-06 CY CY20071100311T patent/CY1106356T1/el unknown
- 2007-05-25 US US11/753,830 patent/US20080096925A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
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