DE60330794D1 - Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer - Google Patents
Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmerInfo
- Publication number
- DE60330794D1 DE60330794D1 DE60330794T DE60330794T DE60330794D1 DE 60330794 D1 DE60330794 D1 DE 60330794D1 DE 60330794 T DE60330794 T DE 60330794T DE 60330794 T DE60330794 T DE 60330794T DE 60330794 D1 DE60330794 D1 DE 60330794D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- alkyl
- cyano
- cycloalkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0215393A GB0215393D0 (en) | 2002-07-03 | 2002-07-03 | Chemical compounds |
| GB0306454A GB0306454D0 (en) | 2003-03-20 | 2003-03-20 | Chemical compounds |
| PCT/EP2003/007127 WO2004005256A2 (en) | 2002-07-03 | 2003-07-02 | Substituted 4-phenyl-piperidin-amides as tachykinin antagonists and serotonin reptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60330794D1 true DE60330794D1 (de) | 2010-02-11 |
Family
ID=30117089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60330794T Expired - Fee Related DE60330794D1 (de) | 2002-07-03 | 2003-07-02 | Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060128752A1 (de) |
| EP (1) | EP1558577B1 (de) |
| JP (1) | JP2005535650A (de) |
| AT (1) | ATE453621T1 (de) |
| AU (1) | AU2003257433A1 (de) |
| DE (1) | DE60330794D1 (de) |
| WO (1) | WO2004005256A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0310724D0 (en) * | 2003-05-09 | 2003-06-11 | Glaxo Group Ltd | Chemical compounds |
| GB0412865D0 (en) | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
| US7098203B2 (en) | 2004-07-20 | 2006-08-29 | Bristol-Myers Squibb Company | Homopiperidine derivatives as NK-1 antagonists |
| US7494986B2 (en) | 2004-07-20 | 2009-02-24 | Bristol-Myers Squibb Company | Cycloalkylamine derivatives as NK-1/SSRI antagonists |
| US7276631B2 (en) | 2004-07-20 | 2007-10-02 | Bristol-Myers Squibb Company | Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists |
| US7138423B2 (en) | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| US7179926B2 (en) | 2004-07-26 | 2007-02-20 | Bristol-Myers Squibb Company | Aryloxyalkylamine NK-1/SSRI inhibitors |
| JP2014159375A (ja) * | 2011-06-15 | 2014-09-04 | Takeda Chem Ind Ltd | アゼパン化合物 |
| DK2729147T3 (en) | 2011-07-04 | 2017-12-18 | Irbm - Science Park S P A | NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA |
| CN106278924B (zh) * | 2016-06-08 | 2018-08-17 | 长沙理工大学 | 一种以取代米氏酸为酰化剂水相中制备n-芳基叔酰胺的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3087209A (en) * | 1959-07-13 | 1963-04-30 | Foremost Dairies Inc | Container sterilizing apparatus |
| NL130088C (de) * | 1960-03-14 | |||
| US3097029A (en) * | 1961-07-07 | 1963-07-09 | Whirlpool Co | Broiler drawer door |
| GB1356117A (en) * | 1970-12-16 | 1974-06-12 | Searle & Co | 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives |
| EP0673367A1 (de) * | 1992-12-14 | 1995-09-27 | MERCK SHARP & DOHME LTD. | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenyl-piperidine als tachykinin rezeptor antagonisten |
| ATE286882T1 (de) * | 1998-05-15 | 2005-01-15 | Aventis Pharma Inc | Carboxy substituierte carboxamidderivative als tachykinin rezeptorantagoniste |
| US6423519B1 (en) * | 1998-07-15 | 2002-07-23 | Gpc Biotech Inc. | Compositions and methods for inhibiting fungal growth |
| FR2784377B3 (fr) * | 1998-10-09 | 2000-11-17 | Sanofi Sa | Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant |
| JP4280073B2 (ja) * | 2001-04-12 | 2009-06-17 | ファーマコペイア ドラッグ ディスカバリー， インコーポレイテッド | Ｍｃｈアンタゴニストとして使用されるアリールピペリジンおよびビアリールピペリジン |
| CA2462953C (en) * | 2001-10-15 | 2011-01-04 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
-
2003
- 2003-07-02 AT AT03762615T patent/ATE453621T1/de not_active IP Right Cessation
- 2003-07-02 DE DE60330794T patent/DE60330794D1/de not_active Expired - Fee Related
- 2003-07-02 AU AU2003257433A patent/AU2003257433A1/en not_active Abandoned
- 2003-07-02 US US10/520,143 patent/US20060128752A1/en not_active Abandoned
- 2003-07-02 JP JP2004518696A patent/JP2005535650A/ja active Pending
- 2003-07-02 EP EP03762615A patent/EP1558577B1/de not_active Expired - Lifetime
- 2003-07-02 WO PCT/EP2003/007127 patent/WO2004005256A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005535650A (ja) | 2005-11-24 |
| ATE453621T1 (de) | 2010-01-15 |
| EP1558577A2 (de) | 2005-08-03 |
| AU2003257433A1 (en) | 2004-01-23 |
| AU2003257433A8 (en) | 2004-01-23 |
| US20060128752A1 (en) | 2006-06-15 |
| WO2004005256A2 (en) | 2004-01-15 |
| WO2004005256A3 (en) | 2004-10-14 |
| EP1558577B1 (de) | 2009-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |