HUP9901016A2 - 4-Kinolinkarboxamid-származékok, előállításuk, valamint neurokinin-3 (NK-3) és neurokinin-2 (NK-2) receptor antagonistákként történő felhasználásuk - Google Patents
4-Kinolinkarboxamid-származékok, előállításuk, valamint neurokinin-3 (NK-3) és neurokinin-2 (NK-2) receptor antagonistákként történő felhasználásukInfo
- Publication number
- HUP9901016A2 HUP9901016A2 HU9901016A HUP9901016A HUP9901016A2 HU P9901016 A2 HUP9901016 A2 HU P9901016A2 HU 9901016 A HU9901016 A HU 9901016A HU P9901016 A HUP9901016 A HU P9901016A HU P9901016 A2 HUP9901016 A2 HU P9901016A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- amino
- carbonyl
- cyclic
- optionally substituted
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 title 1
- 102100024304 Protachykinin-1 Human genes 0.000 title 1
- LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 carboxy- Chemical class 0.000 abstract 4
- 239000000843 powder Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- GZAINRLYQOVLRP-UHFFFAOYSA-N 2-[cyano(nitro)amino]-2-oxoacetic acid Chemical compound [N+](=O)([O-])N(C(=O)C(=O)O)C#N GZAINRLYQOVLRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010040722 Neurokinin-2 Receptors Proteins 0.000 abstract 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 abstract 1
- 102100029409 Neuromedin-K receptor Human genes 0.000 abstract 1
- 102100037342 Substance-K receptor Human genes 0.000 abstract 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000005265 dialkylamine group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003431 oxalo group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
A találmány egy (I) általánős képletű vegyületre - amelynek képletében Ar adőtt esetben szűbsztitűált aril-, ciklőalkadienil- vagy adőttesetben szűbsztitűált, mőnőciklűsős vagy kőndenzált gyűrűs, arőmásheterőciklűsős csőpőrt; R alkil-, ciklőalkil-, ciklőalkil-alkil-, adőtt esetben szűbsztitűáltfenil- vagy fenil-(1-6 szénatőmős alkil)-, adőtt esetben szűbsztitűáltöttagú, legfeljebb négy, az őxigén- és/vagy nitrőgénatőm közülkiválasztőtt heterőatőmőt tartalmazó heterőarőmás csőpőrt, hidrőxi-alkil-, aminő-alkil-, alkil-aminő-alkil-, dialkil-aminő-alkil-, acil-aminő-alkil-, alkőxi-alkil-, alkil-karbőnil-, karbőxi-, alkőxi-karbőnil-, alkőxi-karbőnil-alkil-, karbamőil-alkil-aminő-karbőnil-,dialkil-aminő-karbőnil-, halőgén-alkil-, vagy egy, az Ar csőpőrt egyikszénatőmjával gyűrűt képező -(CH2)p- általánős képletű csőpőrt,amelyben p 2 vagy 3; R1 hidrőgénatőm vagy adőtt esetben legfeljebb négy szűbsztitűens akövetkezők közül: alkil-, alkenil-, aril-, alkőxi-, hidrőxicsőpőrt,halőgénatőm, nitrő-, cianő-, karbőxi-, karbőxamidő-, szűlfőnamidő-,alkőxi-karbőnil-, triflűőrmetil-, acil-őxi, ftálimidő-, aminő-, mőnő-vagy dialkil-aminő-csőpőrt; R2 hidrőgénatőm, alkil-, hidrőxi-, halőgénatőm, cianő-, aminő-, mőnő-vagy dialkil-aminő-, alki-szűlfőnil-aminő-, mőnő- vagy dialkanőil-aminő-, ahől bármely alkilcsőpőrt adőtt esetben aminő- vagy dialkil-aminő-csőpőrttal szűbsztitűált, vagy -X-(CH2)n-Y általánős képletűcsőpőrt; R3 alkil-, ciklőalkil-, ciklőalkil-alkil-, adőtt esetben szűbsztitűáltaril- vagy mőnőciklűsős, vagy kőndenzált gyűrűs, arőmás heterőciklűsőscsőpőrt; és R4 hidrőgénatőm vagy alkilcsőpőrt - vagy a vegyületnek egyszőlvátjára, vagy sójára vőnatkőzik. A találmány szerinti vegyületekNK-3 és NK-2 receptőr antagőnisták. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002462 IT1276171B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
| ITMI961688 IT1307330B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
| PCT/EP1996/005207 WO1997019926A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901016A2 true HUP9901016A2 (hu) | 2000-03-28 |
| HUP9901016A3 HUP9901016A3 (en) | 2002-01-28 |
Family
ID=26331327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901016A HUP9901016A3 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3(nk-3)-and neurokinin 2(nk-2) receptor antagonists |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20020068827A1 (hu) |
| EP (1) | EP1019377A1 (hu) |
| JP (1) | JP2000513325A (hu) |
| KR (1) | KR19990071598A (hu) |
| CN (1) | CN1207729A (hu) |
| AP (1) | AP9801238A0 (hu) |
| AR (1) | AR004735A1 (hu) |
| AU (1) | AU1031897A (hu) |
| BG (1) | BG102557A (hu) |
| BR (1) | BR9611757A (hu) |
| CA (1) | CA2238328A1 (hu) |
| CZ (1) | CZ158098A3 (hu) |
| DZ (1) | DZ2128A1 (hu) |
| EA (1) | EA001771B1 (hu) |
| HU (1) | HUP9901016A3 (hu) |
| IL (1) | IL124418A0 (hu) |
| MA (1) | MA24011A1 (hu) |
| MX (1) | MX9804108A (hu) |
| NO (1) | NO311213B1 (hu) |
| OA (1) | OA11011A (hu) |
| PL (1) | PL326928A1 (hu) |
| SK (1) | SK66898A3 (hu) |
| TR (1) | TR199800883T2 (hu) |
| TW (1) | TW409123B (hu) |
| UY (2) | UY24375A1 (hu) |
| WO (1) | WO1997019926A1 (hu) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041506A1 (en) * | 1997-03-14 | 1998-09-24 | Smithkline Beecham Corporation | Novel quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain |
| WO1998052942A1 (en) * | 1997-05-23 | 1998-11-26 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
| US6339089B2 (en) | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
| US6262070B1 (en) | 1998-11-04 | 2001-07-17 | Darwin Discovery Ltd. | Heterocyclic compounds and their therapeutic use |
| GB9825554D0 (en) | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| IL143137A0 (en) * | 1998-11-20 | 2002-04-21 | Smithkline Beecham Spa | Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
| US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
| DK1035115T3 (da) * | 1999-02-24 | 2005-01-24 | Hoffmann La Roche | 4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister |
| US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| WO2000058307A2 (en) * | 1999-03-11 | 2000-10-05 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: nk3 receptor ligands |
| EP1165542B1 (en) | 1999-03-29 | 2003-08-20 | Neurogen Corporation | 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands |
| AU4802500A (en) * | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| TWI259180B (en) | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| WO2002013825A1 (en) * | 2000-08-11 | 2002-02-21 | Smithkline Beecham P.L.C. | Novel pharmaceutical use of quinnoline derivatives |
| WO2002038547A1 (en) * | 2000-11-13 | 2002-05-16 | Glaxosmithkline Spa | Quinoline derivatives as nk-3 and nk-2 antagonists |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
| EP1385839B1 (en) * | 2001-04-11 | 2006-02-22 | GlaxoSmithKline S.p.A. | 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
| AU2003244080A1 (en) * | 2002-06-26 | 2004-01-19 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| WO2005000247A2 (en) * | 2003-06-25 | 2005-01-06 | Smithkline Beecham Corporation | 4-carboxamido quinoline derivatives for use as nk-2 and nk-3 |
| US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
| SE0302139D0 (sv) * | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
| GB0318727D0 (en) * | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| CN101189211A (zh) * | 2005-06-03 | 2008-05-28 | 阿斯利康(瑞典)有限公司 | 作为nk3拮抗剂的喹啉衍生物 |
| CN101208304A (zh) * | 2005-06-23 | 2008-06-25 | 阿斯利康(瑞典)有限公司 | 作为nk3受体调节剂的喹啉3-磺酸酯 |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| JP2009504640A (ja) * | 2005-08-11 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | Ｎｋ−３受容体の調節剤としてのアミドアルキルピリジルキノリン |
| CN101282964A (zh) * | 2005-08-11 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 作为nk3受体调节剂的氧-吡啶基喹啉酰胺 |
| JP2009504641A (ja) * | 2005-08-11 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | Ｎｋ−３受容体の調節剤としてのアルキルピリジルキノリン |
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| AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| MX2009010059A (es) | 2007-03-22 | 2009-10-12 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias. |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| CN102924375B (zh) * | 2012-06-21 | 2015-02-18 | 江苏恩华药业股份有限公司 | Talnetant中间体及其制备方法和应用 |
| US9475773B2 (en) | 2013-04-19 | 2016-10-25 | Astrazeneca Ab | NK3 receptor antagonist compound (NK3RA) for use in a method for the treatment of polycystic ovary syndrome (PCOS) |
| EP3191452A1 (de) | 2014-09-09 | 2017-07-19 | Bayer Pharma Aktiengesellschaft | Substituierte n,2-diarylchinolin-4-carboxamide und ihre anti-inflammatorische verwendung |
| EP3271334A1 (de) | 2015-03-18 | 2018-01-24 | Bayer Pharma Aktiengesellschaft | Substituierte n-bicyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
| WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| WO2017153234A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017153231A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung |
| TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
| EA201992386A1 (ru) * | 2017-04-10 | 2020-03-27 | Байер Акциенгезельшафт | Замещенные n-арилэтил-2-арилхинолин-4-карбоксамиды и их применение |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| EP0585913B1 (en) * | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| DE69533408T2 (de) * | 1994-05-27 | 2005-09-08 | Glaxosmithkline S.P.A. | Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-21 AR ARP960105282A patent/AR004735A1/es unknown
- 1996-11-22 UY UY24375A patent/UY24375A1/es not_active IP Right Cessation
- 1996-11-22 CZ CZ981580A patent/CZ158098A3/cs unknown
- 1996-11-22 HU HU9901016A patent/HUP9901016A3/hu unknown
- 1996-11-22 IL IL12441896A patent/IL124418A0/xx unknown
- 1996-11-22 JP JP09520158A patent/JP2000513325A/ja active Pending
- 1996-11-22 PL PL96326928A patent/PL326928A1/xx unknown
- 1996-11-22 AP APAP/P/1998/001238A patent/AP9801238A0/en unknown
- 1996-11-22 AU AU10318/97A patent/AU1031897A/en not_active Abandoned
- 1996-11-22 MA MA24399A patent/MA24011A1/fr unknown
- 1996-11-22 SK SK668-98A patent/SK66898A3/sk unknown
- 1996-11-22 KR KR1019980703874A patent/KR19990071598A/ko not_active Application Discontinuation
- 1996-11-22 CA CA002238328A patent/CA2238328A1/en not_active Abandoned
- 1996-11-22 BR BR9611757A patent/BR9611757A/pt unknown
- 1996-11-22 WO PCT/EP1996/005207 patent/WO1997019926A1/en not_active Application Discontinuation
- 1996-11-22 EP EP96941025A patent/EP1019377A1/en not_active Withdrawn
- 1996-11-22 EA EA199800538A patent/EA001771B1/ru not_active IP Right Cessation
- 1996-11-22 CN CN96199747A patent/CN1207729A/zh active Pending
- 1996-11-22 TR TR1998/00883T patent/TR199800883T2/xx unknown
- 1996-11-23 DZ DZ960173A patent/DZ2128A1/fr active
- 1996-11-23 TW TW085114501A patent/TW409123B/zh not_active IP Right Cessation
-
1997
- 1997-05-16 UY UY24555A patent/UY24555A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 MX MX9804108A patent/MX9804108A/es unknown
- 1998-05-22 NO NO19982333A patent/NO311213B1/no not_active IP Right Cessation
- 1998-05-22 OA OA9800062A patent/OA11011A/en unknown
- 1998-06-18 BG BG102557A patent/BG102557A/bg unknown
-
2001
- 2001-11-26 US US09/994,402 patent/US20020068827A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO982333D0 (no) | 1998-05-22 |
| CZ158098A3 (cs) | 1998-10-14 |
| WO1997019926A1 (en) | 1997-06-05 |
| EA001771B1 (ru) | 2001-08-27 |
| EA199800538A1 (ru) | 1998-12-24 |
| AU1031897A (en) | 1997-06-19 |
| CN1207729A (zh) | 1999-02-10 |
| IL124418A0 (en) | 1998-12-06 |
| MA24011A1 (fr) | 1997-07-01 |
| KR19990071598A (ko) | 1999-09-27 |
| MX9804108A (es) | 1998-09-30 |
| AP9801238A0 (en) | 1998-06-30 |
| US20020068827A1 (en) | 2002-06-06 |
| JP2000513325A (ja) | 2000-10-10 |
| DZ2128A1 (fr) | 2002-10-26 |
| SK66898A3 (en) | 1998-12-02 |
| HUP9901016A3 (en) | 2002-01-28 |
| PL326928A1 (en) | 1998-11-09 |
| AR004735A1 (es) | 1999-03-10 |
| EP1019377A1 (en) | 2000-07-19 |
| TW409123B (en) | 2000-10-21 |
| UY24375A1 (es) | 1997-05-22 |
| CA2238328A1 (en) | 1997-06-05 |
| UY24555A1 (es) | 2001-04-30 |
| BG102557A (bg) | 1999-03-31 |
| BR9611757A (pt) | 1999-04-06 |
| OA11011A (en) | 2003-03-06 |
| NO982333L (no) | 1998-07-22 |
| NO311213B1 (no) | 2001-10-29 |
| TR199800883T2 (xx) | 2000-12-21 |
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