ATE182889T1 - Bicyclische amidinderivate als no-synthetase inhibitoren - Google Patents

Bicyclische amidinderivate als no-synthetase inhibitoren

Info

Publication number
ATE182889T1
ATE182889T1 AT95918069T AT95918069T ATE182889T1 AT E182889 T1 ATE182889 T1 AT E182889T1 AT 95918069 T AT95918069 T AT 95918069T AT 95918069 T AT95918069 T AT 95918069T AT E182889 T1 ATE182889 T1 AT E182889T1
Authority
AT
Austria
Prior art keywords
synthetase inhibitors
amideine
bicyclic
derivatives
formula
Prior art date
Application number
AT95918069T
Other languages
English (en)
Inventor
James Edwin Macdonald
William Calvin Shakespeare
Robert John Murray
James Russell Matz
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9409201A external-priority patent/GB9409201D0/en
Priority claimed from GB9409462A external-priority patent/GB9409462D0/en
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of ATE182889T1 publication Critical patent/ATE182889T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
AT95918069T 1994-05-07 1995-05-09 Bicyclische amidinderivate als no-synthetase inhibitoren ATE182889T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409201A GB9409201D0 (en) 1994-05-07 1994-05-07 Pharmaceutically active compounds
GB9409462A GB9409462D0 (en) 1994-05-12 1994-05-12 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
ATE182889T1 true ATE182889T1 (de) 1999-08-15

Family

ID=26304851

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918069T ATE182889T1 (de) 1994-05-07 1995-05-09 Bicyclische amidinderivate als no-synthetase inhibitoren

Country Status (14)

Country Link
US (2) US5807886A (de)
EP (1) EP0759027B1 (de)
JP (1) JPH10500138A (de)
AT (1) ATE182889T1 (de)
AU (1) AU682768B2 (de)
CA (1) CA2188680A1 (de)
DE (1) DE69511260T2 (de)
DK (1) DK0759027T3 (de)
ES (1) ES2137512T3 (de)
FI (1) FI964463A0 (de)
GR (1) GR3031693T3 (de)
MX (1) MX9605366A (de)
NO (1) NO964698L (de)
WO (1) WO1996001817A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE291909T1 (de) * 1994-05-11 2005-04-15 Jes Olesen Verwendung der no-faenger, inhibitoren oder antagonisten zur behandlung von migraene
KR970706272A (ko) * 1995-08-10 1997-11-03 클래스 빌헬름슨 치료에 유용한 바이시클릭 아미딘 유도체(Bicyclic Amidine Derivatives Useful in Therapy)
RU2155761C2 (ru) * 1995-08-10 2000-09-10 Астра АБ Бициклические производные амидина, способ их получения, фармацевтическая композиция и способ ингибирования синтетазы окиси азота
EP0914322A1 (de) * 1996-05-27 1999-05-12 Fujisawa Pharmaceutical Co., Ltd. Neue indolyl und benzofuranylcarboxamide als inhibitoren der stickoxidproduktion
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2764889B1 (fr) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6335445B1 (en) 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
US6166030A (en) * 1997-05-05 2000-12-26 Astra Aktiebolag Compounds
WO1999057114A1 (en) * 1998-05-04 1999-11-11 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic carboxamide derivatives as inhibitors of nitric oxide production
US6288234B1 (en) * 1998-06-08 2001-09-11 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7241774B2 (en) * 2002-03-13 2007-07-10 University Of Tennessee Research Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
TWI417099B (zh) * 2007-03-23 2013-12-01 Neuraxon Inc 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135043C (de) * 1963-10-11
GB1145278A (en) * 1964-07-07 1969-03-12 Wellcome Found Amidine derivatives, processes for their preparation, and compositions incorporating them
GB1188956A (en) * 1967-07-14 1970-04-22 Delalande Sa N-Substituted Aromatic Amidines and process for obtaining same
GB1180629A (en) * 1967-07-14 1970-02-04 Delalande Sa Di-Amidines derived from Aromatic Diamines and process for obtaining same
US3669974A (en) * 1971-03-25 1972-06-13 Usv Pharma Corp N,n1-disubstituted benzamidines
DE2321330A1 (de) * 1973-04-27 1974-11-07 Bayer Ag Azolyl-amidine, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
JPS5246949B2 (de) * 1973-10-19 1977-11-29
US3903163A (en) * 1974-10-02 1975-09-02 Dow Chemical Co N,N-Disubstituted naphthaleneacetamidines
US4073639A (en) * 1975-01-06 1978-02-14 United Technologies Corporation Metallic filler material
IE62023B1 (en) * 1989-01-02 1994-12-14 Boots Co Plc Therapeutic agents
AU636713B2 (en) * 1990-02-26 1993-05-06 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
AU671071B2 (en) * 1990-08-30 1996-08-15 State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, Substituted amidines having high binding to the sigma receptor and the use thereof
US5246971A (en) * 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
JP3251673B2 (ja) * 1991-12-16 2002-01-28 ワシントン ユニバーシティー 酸化窒素生成の抑制方法
WO1993013066A1 (en) * 1991-12-20 1993-07-08 Syntex (U.S.A.) Inc. Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
US5362747A (en) * 1992-11-25 1994-11-08 Abbott Laboratories 2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
WO1994021621A1 (en) * 1993-03-23 1994-09-29 Astra Aktiebolag Guanidine derivatives useful in therapy
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
PL180081B1 (pl) * 1993-08-12 2000-12-29 Astra Ab Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
EP0723438A1 (de) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substitutierte harnstoff und isothioharnstoff derivate als no synthase inhibitoren
GB9320484D0 (en) * 1993-10-05 1993-11-24 Wellcome Found Pharmaceutical combinations
WO1995010266A1 (fr) * 1993-10-13 1995-04-20 Otsuka Pharmaceutical Co., Ltd. Inhibiteur de synthese de monoxyde d'azote
US5854234A (en) * 1993-10-21 1998-12-29 G. D. Searle & Co. Amidino dervatives useful as nitric oxide synthase inhibitors
DK0724435T3 (da) * 1993-10-21 2002-11-25 Searle & Co Amidinoderivater, der er nyttige som nitrogenoxid-synthase-inhibitorer
US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
NO964698D0 (no) 1996-11-06
US5807886A (en) 1998-09-15
JPH10500138A (ja) 1998-01-06
WO1996001817A1 (en) 1996-01-25
DK0759027T3 (da) 2000-03-27
EP0759027B1 (de) 1999-08-04
AU682768B2 (en) 1997-10-16
CA2188680A1 (en) 1996-01-25
FI964463A7 (fi) 1996-11-06
GR3031693T3 (en) 2000-02-29
NO964698L (no) 1996-11-06
US6117898A (en) 2000-09-12
FI964463L (fi) 1996-11-06
MX9605366A (es) 1997-12-31
DE69511260T2 (de) 2000-03-16
DE69511260D1 (en) 1999-09-09
FI964463A0 (fi) 1996-11-06
EP0759027A1 (de) 1997-02-26
AU2413995A (en) 1996-02-09
ES2137512T3 (es) 1999-12-16
HK1009043A1 (en) 1999-05-21

Similar Documents

Publication Publication Date Title
ATE182889T1 (de) Bicyclische amidinderivate als no-synthetase inhibitoren
BG95818A (en) Herbicides
MY131297A (en) Herbicides
ES2188280T3 (es) Acetales heteroaril-ciclicos.
NO982913L (no) Kinolin- og kinazolinforbindelser nyttige i terapi
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
MY104850A (en) N-phenyloyrazole derivatives
NZ221699A (en) Pyridazinone derivatives; pharmaceutical compositions and intermediates
NO960441L (no) Benzopyraner og farmasöytiske forbindelser inneholdende dem
HUT43787A (en) Process for production of medical compounds decreasing blood-pressure
NO961404L (no) 4-indolylpiperazinyl-derivater
YU165791A (sh) Postupak za pripremanje derivata 8-hlorohinolona
EA200400469A1 (ru) Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
HUP9701325A1 (hu) Új 2,3-benzodiazepin-származékok
TW429147B (en) Pharmaceutical composition for the treatment of CNS disorders
AU547599B2 (en) Tricyclic compounds
DK44779A (da) 2-chlorsulfinylazetidin-4-on-forbindelser til anvendelse som mellemprodukter ved fremstilling af 3-exomethylencephamsulfoxider
MY102128A (en) Phenoxybenzamide derivatives, their preparation and herbicidal compositions containing them

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee