NO960441L - Benzopyraner og farmasöytiske forbindelser inneholdende dem - Google Patents

Benzopyraner og farmasöytiske forbindelser inneholdende dem

Info

Publication number
NO960441L
NO960441L NO960441A NO960441A NO960441L NO 960441 L NO960441 L NO 960441L NO 960441 A NO960441 A NO 960441A NO 960441 A NO960441 A NO 960441A NO 960441 L NO960441 L NO 960441L
Authority
NO
Norway
Prior art keywords
compounds
optionally
formula
substituted
group
Prior art date
Application number
NO960441A
Other languages
English (en)
Other versions
NO960441D0 (no
Inventor
Alexander Roderick Mackenzie
Sandra Marina Monaghan
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of NO960441D0 publication Critical patent/NO960441D0/no
Publication of NO960441L publication Critical patent/NO960441L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse vedrører forbindelser med. formel (I) og de farmasøytisk akseptable salter derav, hvor X betyr 0, S eller NH; R og Rhver uavhengig utvelges fra H og C-C-alkyl, eller sammen betyr C-C-alkylen; RJ betyr H eller C^-C^-alkyl; R(a) betyr en 6-leddet heterocyklisk ring inneholdende 1 eller 2 N-heteroatomer, som er bundet til X med et ringkarbon-. atom, valgfritt kan være benzkondensert og valgfritt kan være substituert, (b) når X betyr NH, betyr en gruppe med formel (i) eller (c) når X betyr NH, betyr en gruppe med formel (j); og Rbetyr fenyl som er substituert med en hydroksygruppe og valgfritt kan være ytterligere substituert med 1 eller 2 substituenter; sammen med sammensetninger inneholdende slike forbin-deiser, anvendelse av, fremgangsmåter ved fremstilling. av og mellomprodukter anvendt ved fremstilling av,. slike forbindelser.
NO960441A 1993-08-04 1996-02-02 Benzopyraner og farmasöytiske forbindelser inneholdende dem NO960441L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939316111A GB9316111D0 (en) 1993-08-04 1993-08-04 Benzopyrans
PCT/EP1994/002387 WO1995004730A1 (en) 1993-08-04 1994-07-18 Benzopyrans and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
NO960441D0 NO960441D0 (no) 1996-02-02
NO960441L true NO960441L (no) 1996-02-02

Family

ID=10739921

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960441A NO960441L (no) 1993-08-04 1996-02-02 Benzopyraner og farmasöytiske forbindelser inneholdende dem

Country Status (28)

Country Link
US (2) US5912244A (no)
EP (1) EP0712398B1 (no)
JP (1) JP2871098B2 (no)
KR (1) KR0175532B1 (no)
CN (1) CN1128536A (no)
AT (1) ATE152716T1 (no)
AU (1) AU684817B2 (no)
CA (1) CA2168563C (no)
CO (1) CO4230234A1 (no)
CZ (1) CZ281853B6 (no)
DE (1) DE69403084T2 (no)
DK (1) DK0712398T3 (no)
EC (1) ECSP941140A (no)
EG (1) EG20525A (no)
ES (1) ES2102870T3 (no)
FI (1) FI960487A0 (no)
GB (1) GB9316111D0 (no)
GR (1) GR3023521T3 (no)
HU (1) HUT75120A (no)
IL (1) IL110488A (no)
NO (1) NO960441L (no)
NZ (1) NZ271344A (no)
PE (1) PE56894A1 (no)
PL (1) PL312788A1 (no)
SG (1) SG42817A1 (no)
TW (1) TW333532B (no)
WO (1) WO1995004730A1 (no)
ZA (1) ZA945774B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
ES2199362T3 (es) * 1996-06-07 2004-02-16 Vanderbilt University Dihidrobenzopirano y compuestos relacionados utiles como agentes anti-inflamatorios.
US6333352B1 (en) * 2000-04-05 2001-12-25 Mimicking Man Manually, Inc. Method of treating benign positional vertigo
PT1818325E (pt) * 2001-04-16 2010-05-12 Schering Corp Ciclobuteno-1,2-dionas 3,4-di-substituídas como ligandos de receptor de quimoquina cxc
CA2461381A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
NZ539903A (en) * 2002-11-12 2008-02-29 Warner Lambert Co Method of stimulating hair growth using benzopyrans
CN1917878A (zh) * 2004-02-12 2007-02-21 沃尼尔·朗伯有限责任公司 刺激毛发生长的方法
US20090110892A1 (en) * 2004-06-30 2009-04-30 General Electric Company System and method for making a graded barrier coating
CN1984650A (zh) * 2004-07-16 2007-06-20 沃尼尔·朗伯有限责任公司 毛发生长促进剂
US20070225357A1 (en) * 2004-07-19 2007-09-27 Pfizer Inc. Formulation for Stimulating Hair Growth
CA2591810A1 (en) * 2004-12-21 2006-06-29 F.Hoffmann-La Roche Ag Chroman derivatives and uses thereof in the treatment of cns disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
ES2058148T3 (es) * 1987-02-04 1994-11-01 Hoechst Ag N-benzopiranil-lactamas sustituidas con alquilo, procedimiento para su preparacion, su empleo, asi como preparados farmaceuticos a base de estos compuestos.
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3824446A1 (de) * 1988-07-19 1990-01-25 Hoechst Ag, 6230 Frankfurt Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege
DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
US5061813A (en) * 1990-04-02 1991-10-29 E. R. Squibb & Sons, Inc. Substituted cyanoimino benzopyranes
GB2242628A (en) * 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
TW244350B (no) * 1991-12-14 1995-04-01 Hoechst Ag
FI930148L (fi) * 1992-01-18 1993-07-19 Hoechst Ag Foerfarande foer enantioselektiv epoxidation av i 6-staellning substituerade kromener

Also Published As

Publication number Publication date
EG20525A (en) 1999-06-30
AU684817B2 (en) 1998-01-08
ES2102870T3 (es) 1997-08-01
SG42817A1 (en) 1997-10-17
ATE152716T1 (de) 1997-05-15
US5912244A (en) 1999-06-15
NO960441D0 (no) 1996-02-02
FI960487A7 (fi) 1996-02-02
JPH08508042A (ja) 1996-08-27
IL110488A (en) 1999-08-17
CO4230234A1 (es) 1995-10-19
IL110488A0 (en) 1994-10-21
CZ33196A3 (en) 1996-05-15
HUT75120A (en) 1997-04-28
CA2168563C (en) 1999-09-07
DE69403084T2 (de) 1997-08-14
GB9316111D0 (en) 1993-09-22
DE69403084D1 (de) 1997-06-12
US6071938A (en) 2000-06-06
JP2871098B2 (ja) 1999-03-17
ECSP941140A (es) 1995-01-16
GR3023521T3 (en) 1997-08-29
PL312788A1 (en) 1996-05-13
CN1128536A (zh) 1996-08-07
FI960487L (fi) 1996-02-02
ZA945774B (en) 1996-02-05
DK0712398T3 (da) 1997-10-27
CZ281853B6 (cs) 1997-02-12
PE56894A1 (es) 1995-02-07
NZ271344A (en) 1997-10-24
WO1995004730A1 (en) 1995-02-16
EP0712398A1 (en) 1996-05-22
EP0712398B1 (en) 1997-05-07
CA2168563A1 (en) 1995-02-16
FI960487A0 (fi) 1996-02-02
KR0175532B1 (ko) 1999-02-18
TW333532B (en) 1998-06-11
AU7494894A (en) 1995-02-28

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application