PE20091036A1 - Derivado de quinolina como antagonista del receptor p2x7 - Google Patents
Derivado de quinolina como antagonista del receptor p2x7Info
- Publication number
- PE20091036A1 PE20091036A1 PE2008001976A PE2008001976A PE20091036A1 PE 20091036 A1 PE20091036 A1 PE 20091036A1 PE 2008001976 A PE2008001976 A PE 2008001976A PE 2008001976 A PE2008001976 A PE 2008001976A PE 20091036 A1 PE20091036 A1 PE 20091036A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- antagonist
- receptor
- formula
- refers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Abstract
SE REFIERE AL COMPUESTO 6-CLORO-N-[(1-HIDROXICICLOHEPTIL)METIL]-2-{(3S)-3-[(2-HIDROXIETIL)AMINO]-PIRROLIDIN-1-IL}QUINOLINA-5-CARBOXAMIDA DE FORMULA (I). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN CONDICIONES DE AMINACION REDUCTORA, DONDE PG ES UN GRUPO PROTECTOR; Y B) FORMAR OPCIONALMENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL COMPUESTO. DICHO COMPUESTO ES ANTAGONISTA DEL RECEPTOR P2X7 SIENDO UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99126507P | 2007-11-30 | 2007-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091036A1 true PE20091036A1 (es) | 2009-08-15 |
Family
ID=40676391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001976A PE20091036A1 (es) | 2007-11-30 | 2008-11-26 | Derivado de quinolina como antagonista del receptor p2x7 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8106073B2 (es) |
EP (1) | EP2225222B1 (es) |
JP (1) | JP2011505356A (es) |
AR (1) | AR069508A1 (es) |
AT (1) | ATE524458T1 (es) |
ES (1) | ES2370960T3 (es) |
HK (1) | HK1148002A1 (es) |
PE (1) | PE20091036A1 (es) |
TW (1) | TW200932229A (es) |
WO (1) | WO2009070116A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008228067B2 (en) * | 2007-03-22 | 2011-12-08 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
US9199939B2 (en) * | 2009-12-17 | 2015-12-01 | Merck Sharp & Dohme Corp. | Quinoline amide M1 receptor positive allosteric modulators |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
ES2574840T3 (es) | 2011-07-22 | 2016-06-22 | Actelion Pharmaceuticals Ltd. | Derivados de amidas heterocíclicas como antagonistas de receptores p2x7 |
EP2804865B1 (en) | 2012-01-20 | 2015-12-23 | Actelion Pharmaceuticals Ltd. | Heterocyclic amide derivatives as p2x7 receptor antagonists |
BR112015013463B1 (pt) | 2012-12-12 | 2022-06-14 | Idorsia Pharmaceuticals Ltd | Derivados de carboxamida indol como antagonistas do receptor de p2x7 |
AR094053A1 (es) | 2012-12-18 | 2015-07-08 | Actelion Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x₇ |
ES2616114T3 (es) | 2013-01-22 | 2017-06-09 | Actelion Pharmaceuticals Ltd. | Derivados de amida heterocíclica como antagonistas del receptor P2X7 |
CA2897459C (en) | 2013-01-22 | 2021-03-02 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
US9399623B2 (en) * | 2014-06-05 | 2016-07-26 | Merck Patent Gmbh | Quinoline derivatives and their use in neurodegenerative diseases |
MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
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CZ20013608A3 (cs) | 1999-04-09 | 2002-05-15 | Astrazeneca Ab | Adamantanové deriváty |
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SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
WO2003087037A1 (en) | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Substituted aryl amides |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302139D0 (sv) | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
SE0402925D0 (sv) | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
US20080058309A1 (en) | 2006-07-27 | 2008-03-06 | Astrazeneca Ab | Novel Compounds 171 |
AU2008228067B2 (en) * | 2007-03-22 | 2011-12-08 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
-
2008
- 2008-11-26 PE PE2008001976A patent/PE20091036A1/es not_active Application Discontinuation
- 2008-11-26 US US12/324,397 patent/US8106073B2/en not_active Expired - Fee Related
- 2008-11-28 ES ES08855156T patent/ES2370960T3/es active Active
- 2008-11-28 AR ARP080105220A patent/AR069508A1/es unknown
- 2008-11-28 TW TW097146304A patent/TW200932229A/zh unknown
- 2008-11-28 AT AT08855156T patent/ATE524458T1/de not_active IP Right Cessation
- 2008-11-28 JP JP2010535919A patent/JP2011505356A/ja not_active Withdrawn
- 2008-11-28 EP EP08855156A patent/EP2225222B1/en not_active Not-in-force
- 2008-11-28 WO PCT/SE2008/051370 patent/WO2009070116A1/en active Application Filing
-
2011
- 2011-03-02 HK HK11102084.0A patent/HK1148002A1/xx not_active IP Right Cessation
Also Published As
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---|---|
ES2370960T3 (es) | 2011-12-26 |
TW200932229A (en) | 2009-08-01 |
EP2225222A4 (en) | 2010-12-01 |
US20090143428A1 (en) | 2009-06-04 |
EP2225222B1 (en) | 2011-09-14 |
WO2009070116A1 (en) | 2009-06-04 |
EP2225222A1 (en) | 2010-09-08 |
ATE524458T1 (de) | 2011-09-15 |
US8106073B2 (en) | 2012-01-31 |
HK1148002A1 (en) | 2011-08-26 |
JP2011505356A (ja) | 2011-02-24 |
AR069508A1 (es) | 2010-01-27 |
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