GB1274652A - Adamantanyl-alkylamine derivatives and their preparation - Google Patents
Adamantanyl-alkylamine derivatives and their preparationInfo
- Publication number
- GB1274652A GB1274652A GB40968/68A GB4096868A GB1274652A GB 1274652 A GB1274652 A GB 1274652A GB 40968/68 A GB40968/68 A GB 40968/68A GB 4096868 A GB4096868 A GB 4096868A GB 1274652 A GB1274652 A GB 1274652A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- atom
- hydrogen
- hydrogen atom
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
- C07C53/136—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
- C07C53/138—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems containing an adamantane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/44—Acyl halides containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/36—Acyl halides
- C07C55/38—Acyl halides containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pivots And Pivotal Connections (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
1,274,652. Antidepressant &c. compositions. LILLY INDUSTRIES Ltd. 28 Oct., 1969 [27 Aug., 1968], No. 40968/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions having antidepressant, -Parkinsonism and -motion sickness and appetite suppressant activity comprise, as active ingredient, at least one 1-aminoalkyladamantane of the general formula wherein n is 1 or 2; R<SP>1</SP> is a hydrogen atom or a C 1-4 alkyl group or, when n is 1, R<SP>1</SP> and R<SP>4</SP> together form a methylene group; R<SP>2</SP> is a hydrogen atom or C 1-4 alkyl group or, when n is 1, a C 1-4 hydroxyalkyl or phenyl-C 1- 4 alkyl group, R<SP>3</SP> is a hydrogen atom or a C 1-4 alkyl group or, when R<SP>2</SP> is a hydrogen atom, R<SP>3</SP> is an amidino, pyrimidinyl or C 1-4 alkylpyrimidinyl group, or NR<SP>2</SP>R<SP>3</SP> is a pyrrolidino, piperidino, NC 1-4 alkylpiperazino or N-C 1-4 hydroxyalkylpiperazino group; R<SP>4</SP> is a hydrogen or chlorine atom or a phenyl group or, when n is 1, a bromine atom or cyclohexyl group; R<SP>5</SP> and R<SP>6</SP> are each a hydrogen atom or, when n is 1, a chlorine atom or phenyl group; provided that one of R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> is not a chlorine atom and the others are hydrogen atoms or R<SP>4</SP> is not a bromine atom and R<SP>5</SP> and R<SP>6</SP> are hydrogen atoms, when R<SP>7</SP>, R<SP>8</SP> and R<SP>9</SP> are hydrogen atoms, R<SP>1</SP> is a hydrogen atom or a C 1-4 alkyl group, one of R<SP>2</SP> and R<SP>3</SP> is a hydrogen atom and the other is a C 1-4 alkyl group and n is 1; R<SP>7</SP> is a hydrogen or bromine atom or a hydroxyl or -(CH 2 ) n - -CHR a <SP>1</SP>-NR a <SP>2</SP>R a <SP>3</SP> group, wherein n is 1 or 2 and R a <SP>1</SP>, R a <SP>2</SP> and R a <SP>3</SP> are each a hydrogen atom or a C 1-4 alkyl group, or, when n is 1, R<SP>7</SP> is a methyl group; and R<SP>8</SP> and R<SP>9</SP> are each a hydrogen atom or, when n is 1, a methyl group; or pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutically acceptable carrier.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB40968/68A GB1274652A (en) | 1968-08-27 | 1968-08-27 | Adamantanyl-alkylamine derivatives and their preparation |
IL6932892A IL32892A (en) | 1968-08-27 | 1969-08-25 | Adamantyl alkylamine derivatives and pharmaceutical compositions containing the same |
CH1435971A CH551365A (en) | 1968-08-27 | 1969-08-26 | PROCESS FOR PREPARING ADAMANTYLAMINES AND USE OF THE PRODUCT OBTAINED BY THIS PROCESS. |
NL6913046A NL6913046A (en) | 1968-08-27 | 1969-08-26 | |
AT817269A AT307380B (en) | 1968-08-27 | 1969-08-26 | Process for the preparation of new aminoalkyladamantanes and their acid addition salts |
BE737975A BE737975A (en) | 1968-08-27 | 1969-08-26 | |
CH143372A CH553149A (en) | 1968-08-27 | 1969-08-26 | PROCESS FOR PREPARING ADAMENTYLAMINES AND USE OF THE PRODUCT OBTAINED BY THIS PROCESS. |
CH1300669A CH538442A (en) | 1968-08-27 | 1969-08-26 | Process for preparing adamantylamines and use of the product obtained by this process |
DK457869A DK131721C (en) | 1968-08-27 | 1969-08-26 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF ADAMANTANYLAMINES OR 3,5,7-TRIMETHYL HOMOLOGE OR ACID ADDITIONAL SALTS THEREOF |
DE19691943404 DE1943404A1 (en) | 1968-08-27 | 1969-08-26 | Adamantanylalkylamine derivatives and processes for their preparation |
SE11809/69A SE364037B (en) | 1968-08-27 | 1969-08-26 | |
FR696929356A FR2016468B1 (en) | 1968-08-27 | 1969-08-27 | |
IE1170/69A IE33929B1 (en) | 1968-08-27 | 1969-08-27 | Adamantanyl alkylamine derivatives and their preparation |
JP47064561A JPS5010856B1 (en) | 1968-08-27 | 1972-06-29 | |
JP47064562A JPS4939256B1 (en) | 1968-08-27 | 1972-06-29 | |
JP47064563A JPS4939257B1 (en) | 1968-08-27 | 1972-06-29 | |
US417174A US3929888A (en) | 1968-08-27 | 1973-11-19 | 2-Phenyl-adamantanealkylamine compounds and their salts |
US05/608,613 US4027035A (en) | 1968-08-27 | 1975-08-28 | Therapeutic uses of adamantanealkylamine compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB40968/68A GB1274652A (en) | 1968-08-27 | 1968-08-27 | Adamantanyl-alkylamine derivatives and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1274652A true GB1274652A (en) | 1972-05-17 |
Family
ID=10417493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB40968/68A Expired GB1274652A (en) | 1968-08-27 | 1968-08-27 | Adamantanyl-alkylamine derivatives and their preparation |
Country Status (12)
Country | Link |
---|---|
JP (3) | JPS5010856B1 (en) |
AT (1) | AT307380B (en) |
BE (1) | BE737975A (en) |
CH (3) | CH551365A (en) |
DE (1) | DE1943404A1 (en) |
DK (1) | DK131721C (en) |
FR (1) | FR2016468B1 (en) |
GB (1) | GB1274652A (en) |
IE (1) | IE33929B1 (en) |
IL (1) | IL32892A (en) |
NL (1) | NL6913046A (en) |
SE (1) | SE364037B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1512679A1 (en) | 2003-09-02 | 2005-03-09 | Rotta Research Laboratorium S.P.A. | Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them |
CN114181091A (en) * | 2021-12-27 | 2022-03-15 | 苏州久显新材料有限公司 | Synthesis process of adamantane triphenylamine |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS507356A (en) * | 1973-05-22 | 1975-01-25 | ||
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
SE0103836D0 (en) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
SE0300480D0 (en) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
EP2139879B1 (en) | 2007-03-22 | 2012-07-11 | AstraZeneca AB | Quinoline derivatives for the treatment of inflammatory diseases |
US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
CN109593042B (en) * | 2018-12-24 | 2021-12-07 | 陕西莱特迈思光电材料有限公司 | Organic electroluminescent material and organic electroluminescent device comprising same |
-
1968
- 1968-08-27 GB GB40968/68A patent/GB1274652A/en not_active Expired
-
1969
- 1969-08-25 IL IL6932892A patent/IL32892A/en unknown
- 1969-08-26 BE BE737975A patent/BE737975A/xx unknown
- 1969-08-26 SE SE11809/69A patent/SE364037B/xx unknown
- 1969-08-26 NL NL6913046A patent/NL6913046A/xx unknown
- 1969-08-26 CH CH1435971A patent/CH551365A/en not_active IP Right Cessation
- 1969-08-26 AT AT817269A patent/AT307380B/en active
- 1969-08-26 DK DK457869A patent/DK131721C/en active
- 1969-08-26 CH CH1300669A patent/CH538442A/en not_active IP Right Cessation
- 1969-08-26 DE DE19691943404 patent/DE1943404A1/en active Pending
- 1969-08-26 CH CH143372A patent/CH553149A/en not_active IP Right Cessation
- 1969-08-27 FR FR696929356A patent/FR2016468B1/fr not_active Expired
- 1969-08-27 IE IE1170/69A patent/IE33929B1/en unknown
-
1972
- 1972-06-29 JP JP47064561A patent/JPS5010856B1/ja active Pending
- 1972-06-29 JP JP47064563A patent/JPS4939257B1/ja active Pending
- 1972-06-29 JP JP47064562A patent/JPS4939256B1/ja active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1512679A1 (en) | 2003-09-02 | 2005-03-09 | Rotta Research Laboratorium S.P.A. | Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them |
JP2005075832A (en) * | 2003-09-02 | 2005-03-24 | Rotta Res Lab Spa | New adamantane derivative having neuroprotective, antidepressant and anti-ischemic activity, and method for producing the same |
US7145037B2 (en) | 2003-09-02 | 2006-12-05 | Rotta Research Laboraturium S.P.A. | Adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them |
CN114181091A (en) * | 2021-12-27 | 2022-03-15 | 苏州久显新材料有限公司 | Synthesis process of adamantane triphenylamine |
Also Published As
Publication number | Publication date |
---|---|
CH553149A (en) | 1974-08-30 |
SE364037B (en) | 1974-02-11 |
CH551365A (en) | 1974-07-15 |
IL32892A (en) | 1975-04-25 |
JPS4939257B1 (en) | 1974-10-24 |
FR2016468B1 (en) | 1973-06-08 |
BE737975A (en) | 1970-02-26 |
IE33929B1 (en) | 1974-12-11 |
DK131721B (en) | 1975-08-25 |
DE1943404A1 (en) | 1970-12-17 |
IL32892A0 (en) | 1969-11-12 |
FR2016468A1 (en) | 1970-05-08 |
JPS5010856B1 (en) | 1975-04-24 |
NL6913046A (en) | 1970-03-03 |
AT307380B (en) | 1973-05-25 |
CH538442A (en) | 1973-06-30 |
DK131721C (en) | 1976-01-26 |
JPS4939256B1 (en) | 1974-10-24 |
IE33929L (en) | 1970-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |