IE33929B1 - Adamantanyl alkylamine derivatives and their preparation - Google Patents

Adamantanyl alkylamine derivatives and their preparation

Info

Publication number
IE33929B1
IE33929B1 IE1170/69A IE117069A IE33929B1 IE 33929 B1 IE33929 B1 IE 33929B1 IE 1170/69 A IE1170/69 A IE 1170/69A IE 117069 A IE117069 A IE 117069A IE 33929 B1 IE33929 B1 IE 33929B1
Authority
IE
Ireland
Prior art keywords
group
atom
hydrogen
hydrogen atom
alkyl group
Prior art date
Application number
IE1170/69A
Other versions
IE33929L (en
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of IE33929L publication Critical patent/IE33929L/en
Publication of IE33929B1 publication Critical patent/IE33929B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/136—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
    • C07C53/138—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems containing an adamantane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/38—Acyl halides
    • C07C53/44—Acyl halides containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/36—Acyl halides
    • C07C55/38—Acyl halides containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

1,274,652. Antidepressant &c. compositions. LILLY INDUSTRIES Ltd. 28 Oct., 1969 [27 Aug., 1968], No. 40968/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions having antidepressant, -Parkinsonism and -motion sickness and appetite suppressant activity comprise, as active ingredient, at least one 1-aminoalkyladamantane of the general formula wherein n is 1 or 2; R<SP>1</SP> is a hydrogen atom or a C 1-4 alkyl group or, when n is 1, R<SP>1</SP> and R<SP>4</SP> together form a methylene group; R<SP>2</SP> is a hydrogen atom or C 1-4 alkyl group or, when n is 1, a C 1-4 hydroxyalkyl or phenyl-C 1- 4 alkyl group, R<SP>3</SP> is a hydrogen atom or a C 1-4 alkyl group or, when R<SP>2</SP> is a hydrogen atom, R<SP>3</SP> is an amidino, pyrimidinyl or C 1-4 alkylpyrimidinyl group, or NR<SP>2</SP>R<SP>3</SP> is a pyrrolidino, piperidino, NC 1-4 alkylpiperazino or N-C 1-4 hydroxyalkylpiperazino group; R<SP>4</SP> is a hydrogen or chlorine atom or a phenyl group or, when n is 1, a bromine atom or cyclohexyl group; R<SP>5</SP> and R<SP>6</SP> are each a hydrogen atom or, when n is 1, a chlorine atom or phenyl group; provided that one of R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> is not a chlorine atom and the others are hydrogen atoms or R<SP>4</SP> is not a bromine atom and R<SP>5</SP> and R<SP>6</SP> are hydrogen atoms, when R<SP>7</SP>, R<SP>8</SP> and R<SP>9</SP> are hydrogen atoms, R<SP>1</SP> is a hydrogen atom or a C 1-4 alkyl group, one of R<SP>2</SP> and R<SP>3</SP> is a hydrogen atom and the other is a C 1-4 alkyl group and n is 1; R<SP>7</SP> is a hydrogen or bromine atom or a hydroxyl or -(CH 2 ) n - -CHR a <SP>1</SP>-NR a <SP>2</SP>R a <SP>3</SP> group, wherein n is 1 or 2 and R a <SP>1</SP>, R a <SP>2</SP> and R a <SP>3</SP> are each a hydrogen atom or a C 1-4 alkyl group, or, when n is 1, R<SP>7</SP> is a methyl group; and R<SP>8</SP> and R<SP>9</SP> are each a hydrogen atom or, when n is 1, a methyl group; or pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutically acceptable carrier. [GB1274652A]
IE1170/69A 1968-08-27 1969-08-27 Adamantanyl alkylamine derivatives and their preparation IE33929B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB40968/68A GB1274652A (en) 1968-08-27 1968-08-27 Adamantanyl-alkylamine derivatives and their preparation

Publications (2)

Publication Number Publication Date
IE33929L IE33929L (en) 1970-02-27
IE33929B1 true IE33929B1 (en) 1974-12-11

Family

ID=10417493

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1170/69A IE33929B1 (en) 1968-08-27 1969-08-27 Adamantanyl alkylamine derivatives and their preparation

Country Status (12)

Country Link
JP (3) JPS4939257B1 (en)
AT (1) AT307380B (en)
BE (1) BE737975A (en)
CH (3) CH551365A (en)
DE (1) DE1943404A1 (en)
DK (1) DK131721C (en)
FR (1) FR2016468B1 (en)
GB (1) GB1274652A (en)
IE (1) IE33929B1 (en)
IL (1) IL32892A (en)
NL (1) NL6913046A (en)
SE (1) SE364037B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS507356A (en) * 1973-05-22 1975-01-25
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
SE0103836D0 (en) * 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
SE0300480D0 (en) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
ITTO20030668A1 (en) 2003-09-02 2005-03-03 Rotta Res Lab S P A O Ra Rottapharm DERIVATIVES OF ADAMANTAN EQUIPPED WITH NEUROPROTECTIVE, ANTIDEPRESSIVE AND ANTI-ISCHEMIC ACTIVITY AND PROCEDURE FOR THEIR PREPARATION.
AU2008228067B2 (en) 2007-03-22 2011-12-08 Astrazeneca Ab Quinoline derivatives for the treatment of inflammatory diseases
PE20091036A1 (en) 2007-11-30 2009-08-15 Astrazeneca Ab QUINOLINE DERIVATIVE AS ANTAGONIST OF THE P2X7 RECEPTOR
CN109593042B (en) * 2018-12-24 2021-12-07 陕西莱特迈思光电材料有限公司 Organic electroluminescent material and organic electroluminescent device comprising same
CN114181091A (en) * 2021-12-27 2022-03-15 苏州久显新材料有限公司 Synthesis process of adamantane triphenylamine

Also Published As

Publication number Publication date
NL6913046A (en) 1970-03-03
CH538442A (en) 1973-06-30
SE364037B (en) 1974-02-11
GB1274652A (en) 1972-05-17
CH551365A (en) 1974-07-15
CH553149A (en) 1974-08-30
BE737975A (en) 1970-02-26
JPS4939257B1 (en) 1974-10-24
JPS5010856B1 (en) 1975-04-24
FR2016468B1 (en) 1973-06-08
DK131721B (en) 1975-08-25
FR2016468A1 (en) 1970-05-08
IE33929L (en) 1970-02-27
DK131721C (en) 1976-01-26
JPS4939256B1 (en) 1974-10-24
DE1943404A1 (en) 1970-12-17
IL32892A0 (en) 1969-11-12
AT307380B (en) 1973-05-25
IL32892A (en) 1975-04-25

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