GB1188434A - Guanidine Derivatives and their preparation - Google Patents

Guanidine Derivatives and their preparation

Info

Publication number
GB1188434A
GB1188434A GB44670/68A GB4467068A GB1188434A GB 1188434 A GB1188434 A GB 1188434A GB 44670/68 A GB44670/68 A GB 44670/68A GB 4467068 A GB4467068 A GB 4467068A GB 1188434 A GB1188434 A GB 1188434A
Authority
GB
United Kingdom
Prior art keywords
sept
preparation
guanidine derivatives
saliuretics
dihydrobenzothiadiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44670/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAB DAUSSE
Original Assignee
LAB DAUSSE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR125036A external-priority patent/FR6107M/fr
Application filed by LAB DAUSSE filed Critical LAB DAUSSE
Publication of GB1188434A publication Critical patent/GB1188434A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
    • C07D241/32—(Amino-pyrazinoyl) guanidines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

1,188,434. Saliuretics. LES LABORATOIRES DAUSSE. 19 Sept., 1968 [20 Sept., 1967; 19 Oct., 1967], No. 44670/68. Heading A5B. [Also in Division C2) Pharmaceutical compositions, having salidiuretic activity and suitable for oral or rectal administration, contain as active ingredients, a novel pyrazinoylguanidine derivative of the formula: wherein X is halogen or trihalomethyl, m is I to 4 and n is 0 to 3 or an acid addition salt thereof, and, if desired, other diuretic agents such as those derived from benzothiadiazine or dihydrobenzothiadiazine. The above compounds may also be combined with any medicine which suffers from the disadvantage of causing an exaggerated elimination of potassium, especially those containing the cortiosteroids.
GB44670/68A 1967-09-20 1968-09-19 Guanidine Derivatives and their preparation Expired GB1188434A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR121577 1967-09-20
FR125036A FR6107M (en) 1967-10-19 1967-10-19

Publications (1)

Publication Number Publication Date
GB1188434A true GB1188434A (en) 1970-04-15

Family

ID=26179540

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44670/68A Expired GB1188434A (en) 1967-09-20 1968-09-19 Guanidine Derivatives and their preparation

Country Status (3)

Country Link
BE (1) BE720932A (en)
DE (1) DE1795346A1 (en)
GB (1) GB1188434A (en)

Also Published As

Publication number Publication date
DE1795346A1 (en) 1972-01-05
BE720932A (en) 1969-03-03

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees