IE34665B1 - Isothioureas and their derivatives - Google Patents

Isothioureas and their derivatives

Info

Publication number
IE34665B1
IE34665B1 IE1345/70A IE134570A IE34665B1 IE 34665 B1 IE34665 B1 IE 34665B1 IE 1345/70 A IE1345/70 A IE 1345/70A IE 134570 A IE134570 A IE 134570A IE 34665 B1 IE34665 B1 IE 34665B1
Authority
IE
Ireland
Prior art keywords
oct
pharmaceutically acceptable
nucleus
forms
gb1296544a
Prior art date
Application number
IE1345/70A
Other versions
IE34665L (en
Original Assignee
Smith Kline & French Lab L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Lab L filed Critical Smith Kline & French Lab L
Publication of IE34665L publication Critical patent/IE34665L/en
Publication of IE34665B1 publication Critical patent/IE34665B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1296544 Antihistamines SMITH KLINE & FRENCH LABORATORIES Ltd 26 Oct 1970 [29 Oct 1969] 52890/69 Heading A5B [Also in Division C2] Pharmaceutical compositions in conventional forms and having antihistamine activity other than at the H1 site comprise a pharmaceutically acceptable carrier and a comcompound of formula wherein n is from 2 to 4; A is such that it forms with the carbon and nitrogen atom shown an unsaturated heterocyclic basic nucleus having five or six atoms, which nucleus may be substituted by one or more halogen or aralkyl groups; R 1 is hydrogen or lower alkyl, R 2 together form an ethylene bridge; or its pharmaceutically acceptable acid addition salts, but excluding simple solutions in absolute ethanol of S-[2-(4(5)-imidazolyl) ethyl] isothiourea. [GB1296544A]
IE1345/70A 1969-10-29 1970-10-19 Isothioureas and their derivatives IE34665B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5289069 1969-10-29

Publications (2)

Publication Number Publication Date
IE34665L IE34665L (en) 1971-04-29
IE34665B1 true IE34665B1 (en) 1975-07-09

Family

ID=10465720

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1345/70A IE34665B1 (en) 1969-10-29 1970-10-19 Isothioureas and their derivatives

Country Status (9)

Country Link
JP (1) JPS4917262B1 (en)
BE (1) BE758145A (en)
CA (1) CA953725A (en)
DE (1) DE2052692A1 (en)
FR (1) FR2070177B1 (en)
GB (1) GB1296544A (en)
IE (1) IE34665B1 (en)
SE (1) SE390303B (en)
ZA (1) ZA707150B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA938556A (en) * 1970-06-25 1973-12-18 Smith Kline And French Laboratories Limited Pharmaceutical compositions containing thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
IE47044B1 (en) 1977-04-20 1983-12-14 Ici Ltd Guanidine derivatives
US4262125A (en) * 1979-07-23 1981-04-14 American Home Products Corporation (1H-Imidazol-5-ylmethyl)isothioureas
IT1201523B (en) * 1982-05-18 1989-02-02 Angeli Inst Spa HETEROCYCLYLPHENYLPHOMRAMIDIN, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
FR2660862B1 (en) * 1990-04-13 1994-09-23 Bioprojet Soc Civ THERAPEUTIC APPLICATION OF HISTAMINE DERIVATIVES, NEW HISTAMINE DERIVATIVE AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS.
US5321039A (en) * 1990-04-13 1994-06-14 Societe Civile Bioprojet Method of inducing a histamine agonist action on H2 receptors
ES2108107T3 (en) * 1991-02-27 1997-12-16 Seed Capital Investments IMIDAZOLE DERIVATIVES THAT HAVE ANTAGONIST ACTIVITY IN THE H3 RECEPTOR OF HISTAMINE.
NL9100365A (en) * 1991-02-27 1992-09-16 Seed Capital Investments New imidazole compounds with activity at histamine H3 receptor - e.g. S-(2-(4-imidazolyl)ethyl)isothiourea (VUF 8325)
GB0404434D0 (en) * 2004-02-27 2004-03-31 Novartis Ag Organic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2548746A (en) * 1947-10-10 1951-04-10 Sharp & Dohme Inc S-(4-thiazolylmethyl)-isothioureas
IL25931A (en) * 1965-07-07 1972-01-27 Merck & Co Inc New 4-or 5-nitro imidazole and 5,6-dihydroimidazo(1,2-a)pyrrol-7-yl-carbamates and pseudo thioureido imidazoles and their preparation

Also Published As

Publication number Publication date
FR2070177A1 (en) 1971-09-10
FR2070177B1 (en) 1974-10-11
CA953725A (en) 1974-08-27
IE34665L (en) 1971-04-29
BE758145A (en) 1971-04-28
JPS4917262B1 (en) 1974-04-27
ZA707150B (en) 1971-07-28
DE2052692A1 (en) 1971-05-06
SE390303B (en) 1976-12-13
GB1296544A (en) 1972-11-15

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