GB1390091A - 4-4-biphenylyl-butyric acid derivatives - Google Patents

4-4-biphenylyl-butyric acid derivatives

Info

Publication number
GB1390091A
GB1390091A GB1241672A GB1241672A GB1390091A GB 1390091 A GB1390091 A GB 1390091A GB 1241672 A GB1241672 A GB 1241672A GB 1241672 A GB1241672 A GB 1241672A GB 1390091 A GB1390091 A GB 1390091A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
halogen atom
atom
analgesic
biphenylyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1241672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712112716 external-priority patent/DE2112716A1/en
Priority claimed from DE19712112840 external-priority patent/DE2112840A1/en
Priority claimed from DE19712112715 external-priority patent/DE2112715A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1390091A publication Critical patent/GB1390091A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1390091 Analgesic &c medicines DR KARL THOMAE GmbH 16 March 1972 [17 March 1971 (3)] 12416/72 Heading A5B [Also in Division C2] Pharmaceutical compositions having antiphlogistic, analgesic and antitussive activity and an inhibiting effect on the aggregation of thrombocytes comprise, as active ingredient, a 4-(4-biphenylyl)-butyric acid derivative of the general formula: wherein R 1 is a hydrogen or halogen atom, or a methyl group with the proviso that R 2 and R 3 do not both represent hydrogen atoms; R 2 is a hydrogen or halogen atom or a cyano, nitro or optionally C 1-4 acylated amino group; R 3 is a hydrogen or halogen atom, with the proviso that at least one of R 1 and R 2 is other than a hydrogen atom and in the case where R 1 is a methyl group, R 2 is other than a hydrogen atom; R 4 is a hydrogen atom or a C 1-4 alkyl group; and A is -CH 2 -, -CHOH- or -CO-, or a physiologically compatible base addition salt thereof, in association with a pharmaceutical carrier or excipient, and may be administered orally, parenterally or rectally in the form of granules, tablets, coated tablets, capsules, pills, syrups, emulsions, suspensions, powders, drops, suppositories or injection solutions. They may contain further physiologically active ingredients, e.g. p-ethoxyacetanilide.
GB1241672A 1971-03-17 1972-03-16 4-4-biphenylyl-butyric acid derivatives Expired GB1390091A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19712112716 DE2112716A1 (en) 1971-03-17 1971-03-17 Biphenylyl-butyric acid derivs. - anti phlogistics
DE19712112840 DE2112840A1 (en) 1971-03-17 1971-03-17 New 4- (4-biphenylyl) butyric acids, their salts and esters
DE19712112715 DE2112715A1 (en) 1971-03-17 1971-03-17 New 4- (4-biphenylyl) -4-hydroxybutyric acids, their salts, esters and lactones

Publications (1)

Publication Number Publication Date
GB1390091A true GB1390091A (en) 1975-04-09

Family

ID=27183276

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1241672A Expired GB1390091A (en) 1971-03-17 1972-03-16 4-4-biphenylyl-butyric acid derivatives

Country Status (6)

Country Link
BE (1) BE780821A (en)
FR (1) FR2130390A1 (en)
GB (1) GB1390091A (en)
IE (1) IE36174B1 (en)
IL (1) IL38999A (en)
NL (1) NL7203400A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATA785173A (en) * 1972-08-17 1975-01-15 Thomae Gmbh Dr K PROCESS FOR PREPARING NEW 4- (4-BIPHENYLYL) -4-HYDROXY-BUTTERIC ACID AMIDES
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids
WO1998009940A1 (en) * 1996-09-04 1998-03-12 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Also Published As

Publication number Publication date
IL38999A (en) 1975-10-15
IE36174B1 (en) 1976-09-01
IL38999A0 (en) 1972-05-30
FR2130390A1 (en) 1972-11-03
BE780821A (en) 1972-09-18
NL7203400A (en) 1972-09-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee