GB1174988A - Novel Benzylaminoimidazoline Derivatives, the preparation thereof and Compositions containing the same - Google Patents
Novel Benzylaminoimidazoline Derivatives, the preparation thereof and Compositions containing the sameInfo
- Publication number
- GB1174988A GB1174988A GB30393/67A GB3039367A GB1174988A GB 1174988 A GB1174988 A GB 1174988A GB 30393/67 A GB30393/67 A GB 30393/67A GB 3039367 A GB3039367 A GB 3039367A GB 1174988 A GB1174988 A GB 1174988A
- Authority
- GB
- United Kingdom
- Prior art keywords
- contain
- benzylaminoimidazoline
- compositions
- hypotensive
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- DXOSVIPCIFJHDK-UHFFFAOYSA-N n-benzyl-4,5-dihydroimidazol-1-amine Chemical class C=1C=CC=CC=1CNN1CCN=C1 DXOSVIPCIFJHDK-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000001077 hypotensive effect Effects 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- HAVZTGSQJIEKPI-UHFFFAOYSA-N benzothiadiazine Chemical compound C1=CC=C2C=NNSC2=C1 HAVZTGSQJIEKPI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 abstract 1
- 229960003602 guanethidine Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
Abstract
1,174,988. Hypotensive compositions. BOEHRINGER INGELHEIM G.m.b.H. 30 June, 1967 [30 June, 1966; 18 Jan., 1967], No. 30393/ 67. Heading A5B. [Also in Division C2] Pharmaceutical compositions having hypotensive activity comprise, as active ingredient, at least one 2-benzylaminoimidazoline-(2) derivative of the general formula: wherein R, is hydrogen or C 1-4 alkyl, R 2 is hydrogen, a halogen, trifluoromethyl or C 1-4 alkyl, and Hal is a halogen, or a non-toxic acid addition salt thereof, in association with a pharmaceutical carrier or excipient. The compositions may also contain other physiologically active ingredients, such as another hypotensive agent (e.g. guanethidine or a benzothiadiazine) and/or a spasmolytic agent. They may be presented in the form of tablets, capsules, suppositories, solutions or powders, which may contain any conventional auxiliary agents, carriers, disintegrating agents or lubricants. Dosage units for oral administration conveniently contain from 0.1 to 100 mg., preferably 1 to 30 mg., of active ingredient.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0087792 | 1966-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1174988A true GB1174988A (en) | 1969-12-17 |
Family
ID=6983950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30393/67A Expired GB1174988A (en) | 1966-06-30 | 1967-06-30 | Novel Benzylaminoimidazoline Derivatives, the preparation thereof and Compositions containing the same |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE700802A (en) |
| CH (1) | CH486466A (en) |
| ES (1) | ES342394A1 (en) |
| FR (1) | FR7072M (en) |
| GB (1) | GB1174988A (en) |
| NL (1) | NL6708160A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140204A2 (en) * | 2008-05-16 | 2009-11-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| JP2011522893A (en) * | 2008-06-09 | 2011-08-04 | アラーガン インコーポレイテッド | How to treat alpha-adrenergic mediated symptoms |
| US20120165380A1 (en) * | 2008-06-09 | 2012-06-28 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
-
1967
- 1967-06-13 NL NL6708160A patent/NL6708160A/xx unknown
- 1967-06-15 CH CH850167A patent/CH486466A/en not_active IP Right Cessation
- 1967-06-27 ES ES342394A patent/ES342394A1/en not_active Expired
- 1967-06-30 GB GB30393/67A patent/GB1174988A/en not_active Expired
- 1967-06-30 BE BE700802D patent/BE700802A/xx unknown
- 1967-09-28 FR FR122668A patent/FR7072M/fr not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2319511A3 (en) * | 2008-05-16 | 2012-08-15 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| WO2009140204A3 (en) * | 2008-05-16 | 2010-01-07 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| JP2011520893A (en) * | 2008-05-16 | 2011-07-21 | アラーガン インコーポレイテッド | Selective subtype alpha 2 adrenergic agents and methods of use thereof |
| WO2009140204A2 (en) * | 2008-05-16 | 2009-11-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| US8486985B2 (en) | 2008-05-16 | 2013-07-16 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| JP2011522893A (en) * | 2008-06-09 | 2011-08-04 | アラーガン インコーポレイテッド | How to treat alpha-adrenergic mediated symptoms |
| US20120165380A1 (en) * | 2008-06-09 | 2012-06-28 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
| US8071636B2 (en) * | 2008-06-09 | 2011-12-06 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
| CN102099032B (en) * | 2008-06-09 | 2014-07-09 | 阿勒根公司 | Methods of treating alpha adrenergic mediated conditions |
| US9034910B2 (en) | 2008-06-09 | 2015-05-19 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
| US20150224080A1 (en) * | 2008-06-09 | 2015-08-13 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
| US9623006B2 (en) * | 2008-06-09 | 2017-04-18 | Allergan, Inc. | Methods of treating α adrenergic mediated conditions |
| US9849113B2 (en) | 2008-06-09 | 2017-12-26 | Allergan, Inc. | Methods of treating α adrenergic mediated conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| CH486466A (en) | 1970-02-28 |
| ES342394A1 (en) | 1968-09-16 |
| NL6708160A (en) | 1968-01-02 |
| BE700802A (en) | 1968-01-02 |
| FR7072M (en) | 1969-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |