GB1296544A - - Google Patents

Info

Publication number
GB1296544A
GB1296544A GB5289069A GB1296544DA GB1296544A GB 1296544 A GB1296544 A GB 1296544A GB 5289069 A GB5289069 A GB 5289069A GB 1296544D A GB1296544D A GB 1296544DA GB 1296544 A GB1296544 A GB 1296544A
Authority
GB
United Kingdom
Prior art keywords
oct
pharmaceutically acceptable
nucleus
forms
comcompound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5289069A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1296544A publication Critical patent/GB1296544A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

1296544 Antihistamines SMITH KLINE & FRENCH LABORATORIES Ltd 26 Oct 1970 [29 Oct 1969] 52890/69 Heading A5B [Also in Division C2] Pharmaceutical compositions in conventional forms and having antihistamine activity other than at the H1 site comprise a pharmaceutically acceptable carrier and a comcompound of formula wherein n is from 2 to 4; A is such that it forms with the carbon and nitrogen atom shown an unsaturated heterocyclic basic nucleus having five or six atoms, which nucleus may be substituted by one or more halogen or aralkyl groups; R 1 is hydrogen or lower alkyl, R 2 together form an ethylene bridge; or its pharmaceutically acceptable acid addition salts, but excluding simple solutions in absolute ethanol of S-[2-(4(5)-imidazolyl) ethyl] isothiourea.
GB5289069A 1969-10-29 1969-10-29 Expired GB1296544A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5289069 1969-10-29

Publications (1)

Publication Number Publication Date
GB1296544A true GB1296544A (en) 1972-11-15

Family

ID=10465720

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5289069A Expired GB1296544A (en) 1969-10-29 1969-10-29

Country Status (9)

Country Link
JP (1) JPS4917262B1 (en)
BE (1) BE758145A (en)
CA (1) CA953725A (en)
DE (1) DE2052692A1 (en)
FR (1) FR2070177B1 (en)
GB (1) GB1296544A (en)
IE (1) IE34665B1 (en)
SE (1) SE390303B (en)
ZA (1) ZA707150B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4262125A (en) * 1979-07-23 1981-04-14 American Home Products Corporation (1H-Imidazol-5-ylmethyl)isothioureas
US4666932A (en) * 1982-05-18 1987-05-19 Istituto De Angeli S.P.A. Formamidine derivatives and pharmaceutical use
FR2660862A1 (en) * 1990-04-13 1991-10-18 Bioprojet Soc Civ THERAPEUTIC APPLICATION OF HISTAMINE DERIVATIVES, A NEW HISTAMINE DERIVATIVE, AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS.
EP0531219A1 (en) * 1991-09-06 1993-03-10 Societe Civile Bioprojet Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs
US5837718A (en) * 1991-02-27 1998-11-17 Seed Capital Investment (Sci) B.V. Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA938556A (en) * 1970-06-25 1973-12-18 Smith Kline And French Laboratories Limited Pharmaceutical compositions containing thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE69222757T2 (en) * 1991-02-27 1998-02-12 Seed Capital Investments IMIDAZOLE DERIVATIVES WITH ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3 RECEPTOR
GB0404434D0 (en) * 2004-02-27 2004-03-31 Novartis Ag Organic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2548746A (en) * 1947-10-10 1951-04-10 Sharp & Dohme Inc S-(4-thiazolylmethyl)-isothioureas
IL25931A (en) * 1965-07-07 1972-01-27 Merck & Co Inc New 4-or 5-nitro imidazole and 5,6-dihydroimidazo(1,2-a)pyrrol-7-yl-carbamates and pseudo thioureido imidazoles and their preparation

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4234735A (en) 1977-04-20 1980-11-18 Imperial Chemical Industries Limited Guanidino imidazoles and thiazoles
US4262126A (en) 1977-04-20 1981-04-14 Imperial Chemical Industries Limited Guanidine derivatives of imidazoles and thiazoles
US4262125A (en) * 1979-07-23 1981-04-14 American Home Products Corporation (1H-Imidazol-5-ylmethyl)isothioureas
US4666932A (en) * 1982-05-18 1987-05-19 Istituto De Angeli S.P.A. Formamidine derivatives and pharmaceutical use
US4699915A (en) * 1982-05-18 1987-10-13 Istituto De Angeli S.P.A. Substituted heterocyclyl-phenylformamidines and salts thereof
FR2660862A1 (en) * 1990-04-13 1991-10-18 Bioprojet Soc Civ THERAPEUTIC APPLICATION OF HISTAMINE DERIVATIVES, A NEW HISTAMINE DERIVATIVE, AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS.
EP0458661A1 (en) * 1990-04-13 1991-11-27 Societe Civile Bioprojet Therapeutical application of histamine H3 receptor agonists, new compounds and their use for the preparation of medicaments
US5321039A (en) * 1990-04-13 1994-06-14 Societe Civile Bioprojet Method of inducing a histamine agonist action on H2 receptors
US5837718A (en) * 1991-02-27 1998-11-17 Seed Capital Investment (Sci) B.V. Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor
EP0531219A1 (en) * 1991-09-06 1993-03-10 Societe Civile Bioprojet Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs

Also Published As

Publication number Publication date
FR2070177A1 (en) 1971-09-10
ZA707150B (en) 1971-07-28
IE34665B1 (en) 1975-07-09
JPS4917262B1 (en) 1974-04-27
BE758145A (en) 1971-04-28
SE390303B (en) 1976-12-13
FR2070177B1 (en) 1974-10-11
CA953725A (en) 1974-08-27
DE2052692A1 (en) 1971-05-06
IE34665L (en) 1971-04-29

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee