UY24555A1 - Nuevos compuestos - Google Patents

Nuevos compuestos

Info

Publication number
UY24555A1
UY24555A1 UY24555A UY24555A UY24555A1 UY 24555 A1 UY24555 A1 UY 24555A1 UY 24555 A UY24555 A UY 24555A UY 24555 A UY24555 A UY 24555A UY 24555 A1 UY24555 A1 UY 24555A1
Authority
UY
Uruguay
Prior art keywords
new compounds
compounds
solvates
envisaged
medicine
Prior art date
Application number
UY24555A
Other languages
English (en)
Inventor
Farina Giardina Grugn Raveglia
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952462 external-priority patent/IT1276171B1/it
Priority claimed from IT96MI001688 external-priority patent/IT1307330B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of UY24555A1 publication Critical patent/UY24555A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se prevé nuevos derivados de quinoleína de fórmula (I); o sales o solvatos de dichos compuestos, composiciones farmacéuticas que contienen dichos compuestos, uso de los mismos en medicina.
UY24555A 1995-11-24 1997-05-16 Nuevos compuestos UY24555A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI952462 IT1276171B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
IT96MI001688 IT1307330B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici

Publications (1)

Publication Number Publication Date
UY24555A1 true UY24555A1 (es) 2001-04-30

Family

ID=26331327

Family Applications (2)

Application Number Title Priority Date Filing Date
UY24375A UY24375A1 (es) 1995-11-24 1996-11-22 Procedimiento para la preparacion de derivados de quinolin-4 -carboxamida
UY24555A UY24555A1 (es) 1995-11-24 1997-05-16 Nuevos compuestos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY24375A UY24375A1 (es) 1995-11-24 1996-11-22 Procedimiento para la preparacion de derivados de quinolin-4 -carboxamida

Country Status (26)

Country Link
US (1) US20020068827A1 (es)
EP (1) EP1019377A1 (es)
JP (1) JP2000513325A (es)
KR (1) KR19990071598A (es)
CN (1) CN1207729A (es)
AP (1) AP9801238A0 (es)
AR (1) AR004735A1 (es)
AU (1) AU1031897A (es)
BG (1) BG102557A (es)
BR (1) BR9611757A (es)
CA (1) CA2238328A1 (es)
CZ (1) CZ158098A3 (es)
DZ (1) DZ2128A1 (es)
EA (1) EA001771B1 (es)
HU (1) HUP9901016A3 (es)
IL (1) IL124418A0 (es)
MA (1) MA24011A1 (es)
MX (1) MX9804108A (es)
NO (1) NO311213B1 (es)
OA (1) OA11011A (es)
PL (1) PL326928A1 (es)
SK (1) SK66898A3 (es)
TR (1) TR199800883T2 (es)
TW (1) TW409123B (es)
UY (2) UY24375A1 (es)
WO (1) WO1997019926A1 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US6100267A (en) * 1997-03-14 2000-08-08 Smithkline Beecham Corporation Quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
BR9809652A (pt) * 1997-05-23 2001-09-11 Smithkline Beecham Spa Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3
US6339089B2 (en) 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
US6262070B1 (en) 1998-11-04 2001-07-17 Darwin Discovery Ltd. Heterocyclic compounds and their therapeutic use
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
TR200101412T2 (tr) * 1998-11-20 2001-10-22 Smithkline Beecham S.P.A. Yeni bileşikler.
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
ES2359235T3 (es) * 1999-02-24 2011-05-19 F. Hoffmann-La Roche Ag Derivados de 4-fenilpiridina y su empleo como antagonistas del receptor nk-1.
EP1165555B1 (en) * 1999-03-11 2003-07-16 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: nk3 receptor ligands
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
TWI259180B (en) 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
EP1334089A1 (en) * 2000-11-13 2003-08-13 GlaxoSmithKline S.p.A. Quinoline derivatives as nk-3 and nk-2 antagonists
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
EP1377567B1 (en) * 2001-04-11 2005-12-21 GlaxoSmithKline S.p.A. Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
AU2003244080A1 (en) * 2002-06-26 2004-01-19 Kyowa Hakko Kogyo Co., Ltd. Phosphodiesterase inhibitor
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
JP2007521276A (ja) * 2003-06-25 2007-08-02 スミスクライン・ビーチャム・コーポレイション Ｎｋ−２およびｎｋ−３として用いるための４−カルボキサミドキノリン誘導体
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
SE0302139D0 (sv) * 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
GB0318727D0 (en) * 2003-08-08 2003-09-10 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
MX2007014831A (es) * 2005-06-03 2008-02-15 Astrazeneca Ab Derivados de quinolina como antagonistas de neurocinina-3.
CN101208304A (zh) * 2005-06-23 2008-06-25 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的喹啉3-磺酸酯
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
JP2009504642A (ja) * 2005-08-11 2009-02-05 アストラゼネカ・アクチエボラーグ Ｎｋ−３受容体の調節剤としてのオキソピリジルキノリンアミド
WO2007018465A1 (en) * 2005-08-11 2007-02-15 Astrazeneca Ab Amide alkyl pyridiyl quinolines as nk3 receptor modulators
EP1915361A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Alkylpyridyl quinolines as nk3 receptor modulators
AR058051A1 (es) * 2005-09-21 2008-01-23 Astrazeneca Ab Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas.
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) * 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
MX2009010059A (es) 2007-03-22 2009-10-12 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias.
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
CN102924375B (zh) * 2012-06-21 2015-02-18 江苏恩华药业股份有限公司 Talnetant中间体及其制备方法和应用
EP2986293A1 (en) 2013-04-19 2016-02-24 Astrazeneca AB A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
CN107074773A (zh) 2014-09-09 2017-08-18 拜耳制药股份公司 取代的n,2‑二芳基喹啉‑4‑甲酰胺及其用途
JP2018512404A (ja) 2015-03-18 2018-05-17 バイエル ファーマ アクチエンゲゼルシャフト 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
WO2017153231A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung
WO2017153235A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung
WO2017153234A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung
TWI770157B (zh) * 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
WO2018189011A1 (de) * 2017-04-10 2018-10-18 Bayer Aktiengesellschaft Substituierte n-arylethyl-2-arylchinolin-4-carboxamide und ihre verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
DE69315920T2 (de) * 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
PL186075B1 (pl) * 1994-05-27 2003-10-31 Smithkline Beechem Spa N-(-etylobenzylo)-3-hydroksy-2-fenylochinolino-4-karboksyamid oraz kompozycja farmaceutyczna zawierająca ten związek
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
NO982333L (no) 1998-07-22
BG102557A (bg) 1999-03-31
CA2238328A1 (en) 1997-06-05
EA199800538A1 (ru) 1998-12-24
MA24011A1 (fr) 1997-07-01
TW409123B (en) 2000-10-21
JP2000513325A (ja) 2000-10-10
DZ2128A1 (fr) 2002-10-26
AR004735A1 (es) 1999-03-10
EP1019377A1 (en) 2000-07-19
CN1207729A (zh) 1999-02-10
KR19990071598A (ko) 1999-09-27
US20020068827A1 (en) 2002-06-06
HUP9901016A2 (hu) 2000-03-28
MX9804108A (es) 1998-09-30
EA001771B1 (ru) 2001-08-27
UY24375A1 (es) 1997-05-22
NO311213B1 (no) 2001-10-29
PL326928A1 (en) 1998-11-09
AU1031897A (en) 1997-06-19
NO982333D0 (no) 1998-05-22
BR9611757A (pt) 1999-04-06
OA11011A (en) 2003-03-06
WO1997019926A1 (en) 1997-06-05
IL124418A0 (en) 1998-12-06
AP9801238A0 (en) 1998-06-30
SK66898A3 (en) 1998-12-02
HUP9901016A3 (en) 2002-01-28
CZ158098A3 (cs) 1998-10-14
TR199800883T2 (xx) 2000-12-21

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Legal Events

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Effective date: 20041021