SE8904298D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE8904298D0
SE8904298D0 SE8904298A SE8904298A SE8904298D0 SE 8904298 D0 SE8904298 D0 SE 8904298D0 SE 8904298 A SE8904298 A SE 8904298A SE 8904298 A SE8904298 A SE 8904298A SE 8904298 D0 SE8904298 D0 SE 8904298D0
Authority
SE
Sweden
Prior art keywords
new compounds
compounds
analgetica
anaesthetica
local
Prior art date
Application number
SE8904298A
Other languages
English (en)
Inventor
A-L Ask
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8904298A priority Critical patent/SE8904298D0/sv
Publication of SE8904298D0 publication Critical patent/SE8904298D0/sv
Priority to NZ236293A priority patent/NZ236293A/xx
Priority to ZA909903A priority patent/ZA909903B/xx
Priority to IL9663690A priority patent/IL96636A/en
Priority to YU234690A priority patent/YU48086B/sh
Priority to SI9012346A priority patent/SI9012346B/sl
Priority to DZ900223A priority patent/DZ1468A1/xx
Priority to UA5052485A priority patent/UA26403A/uk
Priority to DK91901571.9T priority patent/DK0506778T3/da
Priority to DE69027221T priority patent/DE69027221T2/de
Priority to AU69783/91A priority patent/AU647068B2/en
Priority to AT91901571T priority patent/ATE138650T1/de
Priority to RO92-0832A priority patent/RO112864B1/ro
Priority to JP3501896A priority patent/JP2656152B2/ja
Priority to CA002069608A priority patent/CA2069608C/en
Priority to PCT/SE1990/000818 priority patent/WO1991009845A1/en
Priority to ES91901571T priority patent/ES2087280T3/es
Priority to IE453490A priority patent/IE74855B1/en
Priority to IS3659A priority patent/IS1664B/is
Priority to SG1996004491A priority patent/SG46413A1/en
Priority to KR1019920701484A priority patent/KR0179382B1/ko
Priority to HU9202044A priority patent/HU213110B/hu
Priority to EP91901571A priority patent/EP0506778B1/en
Priority to EG74690A priority patent/EG19361A/xx
Priority to PT96303A priority patent/PT96303B/pt
Priority to SK6581-90A priority patent/SK658190A3/sk
Priority to PL90288409A priority patent/PL163591B1/pl
Priority to US07/633,246 priority patent/US5227389A/en
Priority to CN90106009A priority patent/CN1037841C/zh
Priority to CS906581A priority patent/CZ278035B6/cs
Priority to SA91110209A priority patent/SA91110209B1/ar
Priority to NO922380A priority patent/NO178858C/no
Priority to FI922806A priority patent/FI100881B/sv
Priority to BG96513A priority patent/BG60912B1/bg
Priority to SU925052485A priority patent/RU2039043C1/ru
Priority to HRP-2346/90A priority patent/HRP920591B1/xx
Priority to US08/090,416 priority patent/US5360805A/en
Priority to LVP-93-1042A priority patent/LV10949B/lv
Priority to LTIP1731A priority patent/LT4005B/lt
Priority to LV960262A priority patent/LV5766B4/xx
Priority to HK22997A priority patent/HK22997A/xx
Priority to BR1100379-0A priority patent/BR1100379A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
SE8904298A 1989-12-21 1989-12-21 New compounds SE8904298D0 (sv)

Priority Applications (42)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds
NZ236293A NZ236293A (en) 1989-12-21 1990-11-30 1-(alkyl or alkoxyalkyl)-4-phenyl piperidine-4-carboxylic acid amide derivatives; preparatory processes and pharmaceutical compositions
ZA909903A ZA909903B (en) 1989-12-21 1990-12-10 New compounds
IL9663690A IL96636A (en) 1989-12-21 1990-12-11 History of piperidine Process for preparation and pharmaceutical preparations containing them
YU234690A YU48086B (sh) 1989-12-21 1990-12-12 Supstituisani 4-fenil-4-piperidinkarboksamid i postupak za njihovo dobijanje
SI9012346A SI9012346B (sl) 1989-12-21 1990-12-12 Substituirani 4-fenil-4-piperidinkarboksamidi z lokalno-anestezijskim in analgetskim učinkom kot tudi postopki za njihovo pripravo
DZ900223A DZ1468A1 (fr) 1989-12-21 1990-12-12 Composés nouveaux.
ES91901571T ES2087280T3 (es) 1989-12-21 1990-12-17 4-fenil-4-piperidina-carboxamidas sustituidas con efecto tanto anestesico local como analgesico, asi como procedimientos para su preparacion.
KR1019920701484A KR0179382B1 (ko) 1989-12-21 1990-12-17 국부 마취 및 진통 효과를 갖는 치환 4-페닐-4-피페리딘카르복스아미드 및 그의 제조 방법
EP91901571A EP0506778B1 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
DE69027221T DE69027221T2 (de) 1989-12-21 1990-12-17 Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
AU69783/91A AU647068B2 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
AT91901571T ATE138650T1 (de) 1989-12-21 1990-12-17 Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
RO92-0832A RO112864B1 (ro) 1989-12-21 1990-12-17 Derivati substituiti ai 4-fenil-4-piperidincarboxamidelor cu efect analgezic si anestezic local, procedeu de obtinere a acestora si compozitie farmaceutica care ii contine
JP3501896A JP2656152B2 (ja) 1989-12-21 1990-12-17 局所麻酔作用および鎮痛作用の両方を有する置換された４―フェニル―４―ピペリジンカルボキサミドならびにその製法
CA002069608A CA2069608C (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
PCT/SE1990/000818 WO1991009845A1 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
DK91901571.9T DK0506778T3 (da) 1989-12-21 1990-12-17 Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling
IE453490A IE74855B1 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
IS3659A IS1664B (is) 1989-12-21 1990-12-17 Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandiog kvalastillandi áhrif
SG1996004491A SG46413A1 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
UA5052485A UA26403A (uk) 1989-12-21 1990-12-17 Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
HU9202044A HU213110B (en) 1989-12-21 1990-12-17 Process for producing 4-phenyl-piperidine-4-carboxamide derivatives and pharmaceutical preparatives containing them as active agents
PT96303A PT96303B (pt) 1989-12-21 1990-12-20 Processo para a preparacao de novos derivados do acido piperidinocarboxilico com accao anestesica local e analgesica e de composicoes farmaceuticas que os contem
EG74690A EG19361A (en) 1989-12-21 1990-12-20 A process for the preparation of piperidine compound having local anaesthetica and analgetic
SK6581-90A SK658190A3 (en) 1989-12-21 1990-12-21 Substituted piperidinecarboxamides, method of their manufacture, pharmaceutical drugs containing them and their application
PL90288409A PL163591B1 (pl) 1989-12-21 1990-12-21 Sposób wytwarzania nowych pochodnych 4-fenylo-4-piperydynokarboksyamldu PL PL PL PL PL
CS906581A CZ278035B6 (en) 1989-12-21 1990-12-21 Substituted piperidinecarboxamides, process of their preparation, pharmaceutical compositions in which they are comprised
US07/633,246 US5227389A (en) 1989-12-21 1990-12-21 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
CN90106009A CN1037841C (zh) 1989-12-21 1990-12-21 具有局部麻醉和止痛作用的取代4－苯基－4－呱啶甲酰胺的制备方法
SA91110209A SA91110209B1 (ar) 1989-12-21 1991-01-09 مركبات 4-فينيل-4- بيبريدين كاربوكساميد مستبدلة Substituted -4- phenyl -4-piperidincarboxamide لها مفعول مخدر موضعي ومسكن وكذلك طرق لتحضيرها
NO922380A NO178858C (no) 1989-12-21 1992-06-17 Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt
FI922806A FI100881B (sv) 1989-12-21 1992-06-17 Förfarande för framställning av farmakologiskt aktiva, substituerade 4 -fenyl-4-piperidinkarboxamider
BG96513A BG60912B1 (bg) 1989-12-21 1992-06-19 Заместени 4-фенил-4-пиперидинкарбоксамиди с локален обезболя- ващ и болкоуспокояващ ефект и метод за получаването им
SU925052485A RU2039043C1 (ru) 1989-12-21 1992-06-19 Производное n-замещенного 1-гексил-4-фенил-4-пиперидинкарбоксамида или его фармацевтически приемлемая соль и способ его получения
HRP-2346/90A HRP920591B1 (en) 1989-12-21 1992-09-29 New compounds
US08/090,416 US5360805A (en) 1989-12-21 1993-07-12 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
LVP-93-1042A LV10949B (en) 1989-12-21 1993-08-27 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
LTIP1731A LT4005B (en) 1989-12-21 1993-12-30 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
LV960262A LV5766B4 (lv) 1989-12-21 1996-07-17 Aizvietoti 4-fenil-4-piperidinkarboksamidi ar lokalu anestezejosu un analgetisku daribu ka ari to iegusanas metodes
HK22997A HK22997A (en) 1989-12-21 1997-02-27 Substituted 4-phenyl-4-piperidine-carboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
BR1100379-0A BR1100379A (pt) 1989-12-21 1997-04-30 Composto, uso de um composto, preparação farmacêutica e processo para preparação de um composto

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds

Publications (1)

Publication Number Publication Date
SE8904298D0 true SE8904298D0 (sv) 1989-12-21

Family

ID=20377821

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds

Country Status (40)

Country Link
US (2) US5227389A (sv)
EP (1) EP0506778B1 (sv)
JP (1) JP2656152B2 (sv)
KR (1) KR0179382B1 (sv)
CN (1) CN1037841C (sv)
AT (1) ATE138650T1 (sv)
AU (1) AU647068B2 (sv)
BG (1) BG60912B1 (sv)
BR (1) BR1100379A (sv)
CA (1) CA2069608C (sv)
CZ (1) CZ278035B6 (sv)
DE (1) DE69027221T2 (sv)
DK (1) DK0506778T3 (sv)
DZ (1) DZ1468A1 (sv)
EG (1) EG19361A (sv)
ES (1) ES2087280T3 (sv)
FI (1) FI100881B (sv)
HK (1) HK22997A (sv)
HR (1) HRP920591B1 (sv)
HU (1) HU213110B (sv)
IE (1) IE74855B1 (sv)
IL (1) IL96636A (sv)
IS (1) IS1664B (sv)
LT (1) LT4005B (sv)
LV (2) LV10949B (sv)
NO (1) NO178858C (sv)
NZ (1) NZ236293A (sv)
PL (1) PL163591B1 (sv)
PT (1) PT96303B (sv)
RO (1) RO112864B1 (sv)
RU (1) RU2039043C1 (sv)
SA (1) SA91110209B1 (sv)
SE (1) SE8904298D0 (sv)
SG (1) SG46413A1 (sv)
SI (1) SI9012346B (sv)
SK (1) SK658190A3 (sv)
UA (1) UA26403A (sv)
WO (1) WO1991009845A1 (sv)
YU (1) YU48086B (sv)
ZA (1) ZA909903B (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
SE9404438D0 (sv) * 1994-12-21 1994-12-21 Astra Ab New process
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US20020102291A1 (en) * 1997-12-15 2002-08-01 Noven Pharmaceuticals, Inc. Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
PE20021081A1 (es) * 2001-04-12 2002-12-18 Pharmacopeia Drug Discovery Aril y biaril piperidinas con actividad moduladora mch
WO2004054974A2 (en) * 2002-12-13 2004-07-01 Smithkline Beecham Corporation Piperidine derivatives as ccr5 antagonists
WO2008045564A2 (en) * 2006-10-12 2008-04-17 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
EP2280766A1 (en) 2007-12-11 2011-02-09 CytoPathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US20220096452A1 (en) 2019-01-22 2022-03-31 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE96980C1 (sv)
US2486796A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) * 1964-10-20 1967-08-01 Aldrich Chem Co Inc N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) * 1967-06-26 1970-11-10 Janssen Pharm 4-aryl-4-aminoalkoxy-piperidines
CH502338A (de) * 1968-12-20 1971-01-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) * 1968-12-30 1973-06-05 Ciba Geigy Corp Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) * 1971-10-21 1973-06-01 Synthelabo 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
PL288409A1 (en) 1991-12-02
EG19361A (en) 1994-12-30
EP0506778B1 (en) 1996-05-29
AU6978391A (en) 1991-07-24
BR1100379A (pt) 1999-12-07
HRP920591A2 (en) 1997-08-31
YU48086B (sh) 1997-01-08
CN1037841C (zh) 1998-03-25
NO922380D0 (no) 1992-06-17
LV10949B (en) 1996-06-20
FI922806A0 (fi) 1992-06-17
SG46413A1 (en) 1998-02-20
IS3659A7 (is) 1991-06-22
JP2656152B2 (ja) 1997-09-24
LV5766B4 (lv) 1997-06-20
DK0506778T3 (da) 1996-10-07
RU2039043C1 (ru) 1995-07-09
FI922806A (fi) 1992-06-17
IL96636A0 (en) 1991-09-16
UA26403A (uk) 1999-08-30
HU9202044D0 (en) 1992-09-28
CA2069608C (en) 2001-07-10
HUT64518A (en) 1994-01-28
DE69027221D1 (de) 1996-07-04
NZ236293A (en) 1992-10-28
WO1991009845A1 (en) 1991-07-11
CN1053605A (zh) 1991-08-07
SA91110209B1 (ar) 2004-05-08
IL96636A (en) 1994-11-28
SK278283B6 (en) 1996-08-07
NO178858B (no) 1996-03-11
NO178858C (no) 1996-06-19
US5227389A (en) 1993-07-13
CZ278035B6 (en) 1993-07-14
FI100881B (sv) 1998-03-13
JPH05502869A (ja) 1993-05-20
CZ658190A3 (en) 1993-01-13
LTIP1731A (en) 1995-07-25
HK22997A (en) 1997-02-27
CA2069608A1 (en) 1991-06-22
HU213110B (en) 1997-02-28
RO112864B1 (ro) 1998-01-30
US5360805A (en) 1994-11-01
ZA909903B (en) 1991-08-28
LV10949A (lv) 1995-12-20
DE69027221T2 (de) 1996-10-10
EP0506778A1 (en) 1992-10-07
KR0179382B1 (ko) 1999-03-20
PT96303A (pt) 1991-09-30
SK658190A3 (en) 1996-08-07
IE74855B1 (en) 1997-08-13
LV5766A4 (lv) 1996-12-20
PL163591B1 (pl) 1994-04-29
KR927003531A (ko) 1992-12-18
LT4005B (en) 1996-07-25
BG60912B1 (bg) 1996-06-28
PT96303B (pt) 1998-07-31
NO922380L (no) 1992-06-17
ES2087280T3 (es) 1996-07-16
ATE138650T1 (de) 1996-06-15
DZ1468A1 (fr) 2004-09-13
YU234690A (sh) 1993-10-20
IS1664B (is) 1997-07-04
AU647068B2 (en) 1994-03-17
IE904534A1 (en) 1991-07-03
SI9012346A (sl) 1998-08-31
HRP920591B1 (en) 1998-12-31
SI9012346B (sl) 1999-08-31

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