DE69027221T2 - Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung - Google Patents

Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung

Info

Publication number
DE69027221T2
DE69027221T2 DE69027221T DE69027221T DE69027221T2 DE 69027221 T2 DE69027221 T2 DE 69027221T2 DE 69027221 T DE69027221 T DE 69027221T DE 69027221 T DE69027221 T DE 69027221T DE 69027221 T2 DE69027221 T2 DE 69027221T2
Authority
DE
Germany
Prior art keywords
localanesthetic
pain
phenyl
substituted
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69027221T
Other languages
English (en)
Other versions
DE69027221D1 (de
Inventor
Anna-Lena Ask
Rune Sandberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE69027221D1 publication Critical patent/DE69027221D1/de
Publication of DE69027221T2 publication Critical patent/DE69027221T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
DE69027221T 1989-12-21 1990-12-17 Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung Expired - Fee Related DE69027221T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds
PCT/SE1990/000818 WO1991009845A1 (en) 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation

Publications (2)

Publication Number Publication Date
DE69027221D1 DE69027221D1 (de) 1996-07-04
DE69027221T2 true DE69027221T2 (de) 1996-10-10

Family

ID=20377821

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69027221T Expired - Fee Related DE69027221T2 (de) 1989-12-21 1990-12-17 Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung

Country Status (40)

Country Link
US (2) US5227389A (de)
EP (1) EP0506778B1 (de)
JP (1) JP2656152B2 (de)
KR (1) KR0179382B1 (de)
CN (1) CN1037841C (de)
AT (1) ATE138650T1 (de)
AU (1) AU647068B2 (de)
BG (1) BG60912B1 (de)
BR (1) BR1100379A (de)
CA (1) CA2069608C (de)
CZ (1) CZ278035B6 (de)
DE (1) DE69027221T2 (de)
DK (1) DK0506778T3 (de)
DZ (1) DZ1468A1 (de)
EG (1) EG19361A (de)
ES (1) ES2087280T3 (de)
FI (1) FI100881B (de)
HK (1) HK22997A (de)
HR (1) HRP920591B1 (de)
HU (1) HU213110B (de)
IE (1) IE74855B1 (de)
IL (1) IL96636A (de)
IS (1) IS1664B (de)
LT (1) LT4005B (de)
LV (2) LV10949B (de)
NO (1) NO178858C (de)
NZ (1) NZ236293A (de)
PL (1) PL163591B1 (de)
PT (1) PT96303B (de)
RO (1) RO112864B1 (de)
RU (1) RU2039043C1 (de)
SA (1) SA91110209B1 (de)
SE (1) SE8904298D0 (de)
SG (1) SG46413A1 (de)
SI (1) SI9012346B (de)
SK (1) SK278283B6 (de)
UA (1) UA26403A (de)
WO (1) WO1991009845A1 (de)
YU (1) YU48086B (de)
ZA (1) ZA909903B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
SE9404438D0 (sv) * 1994-12-21 1994-12-21 Astra Ab New process
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US20020102291A1 (en) * 1997-12-15 2002-08-01 Noven Pharmaceuticals, Inc. Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
AR035234A1 (es) * 2001-04-12 2004-05-05 Pharmacopeia Drug Discovery Aril y biaril-piperidinas con actividad moduladora mch, metodo para preparar dichos compuestos, composiciones farmaceuticas, metodo para preparar las composiciones farmaceuticas y el uso de dichos compuestos para la manufactura de un medicamento
RU2005118407A (ru) * 2002-12-13 2006-03-10 СмитКлайн Бичем Корпорейшн (US) Производные пиперидина в качестве антагонистов ccr5
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
KR20100102646A (ko) 2007-12-11 2010-09-24 가부시키가이샤 사이토파스파인더 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
WO2020152212A1 (en) 2019-01-22 2020-07-30 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE96980C1 (de)
US2486796A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) * 1964-10-20 1967-08-01 Aldrich Chem Co Inc N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) * 1967-06-26 1970-11-10 Janssen Pharm 4-aryl-4-aminoalkoxy-piperidines
CH502338A (de) * 1968-12-20 1971-01-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) * 1968-12-30 1973-06-05 Ciba Geigy Corp Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) * 1971-10-21 1973-06-01 Synthelabo 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
NO178858B (no) 1996-03-11
HU213110B (en) 1997-02-28
HRP920591A2 (en) 1997-08-31
FI100881B (fi) 1998-03-13
LV5766B4 (lv) 1997-06-20
IS1664B (is) 1997-07-04
BR1100379A (pt) 1999-12-07
NO922380D0 (no) 1992-06-17
DZ1468A1 (fr) 2004-09-13
BG96513A (bg) 1993-12-24
US5360805A (en) 1994-11-01
ZA909903B (en) 1991-08-28
CN1053605A (zh) 1991-08-07
EP0506778A1 (de) 1992-10-07
IS3659A7 (is) 1991-06-22
FI922806A (fi) 1992-06-17
CZ658190A3 (en) 1993-01-13
HK22997A (en) 1997-02-27
ES2087280T3 (es) 1996-07-16
HUT64518A (en) 1994-01-28
YU48086B (sh) 1997-01-08
SA91110209B1 (ar) 2004-05-08
IE904534A1 (en) 1991-07-03
NO922380L (no) 1992-06-17
NO178858C (no) 1996-06-19
CA2069608C (en) 2001-07-10
AU647068B2 (en) 1994-03-17
JPH05502869A (ja) 1993-05-20
FI922806A0 (fi) 1992-06-17
CA2069608A1 (en) 1991-06-22
PT96303B (pt) 1998-07-31
EG19361A (en) 1994-12-30
EP0506778B1 (de) 1996-05-29
PL163591B1 (pl) 1994-04-29
RU2039043C1 (ru) 1995-07-09
RO112864B1 (ro) 1998-01-30
LT4005B (en) 1996-07-25
HRP920591B1 (en) 1998-12-31
WO1991009845A1 (en) 1991-07-11
CN1037841C (zh) 1998-03-25
JP2656152B2 (ja) 1997-09-24
ATE138650T1 (de) 1996-06-15
LV10949A (lv) 1995-12-20
SG46413A1 (en) 1998-02-20
SI9012346A (sl) 1998-08-31
UA26403A (uk) 1999-08-30
LV10949B (en) 1996-06-20
LV5766A4 (lv) 1996-12-20
KR927003531A (ko) 1992-12-18
CZ278035B6 (en) 1993-07-14
IE74855B1 (en) 1997-08-13
KR0179382B1 (ko) 1999-03-20
YU234690A (sh) 1993-10-20
IL96636A0 (en) 1991-09-16
PT96303A (pt) 1991-09-30
SE8904298D0 (sv) 1989-12-21
AU6978391A (en) 1991-07-24
LTIP1731A (en) 1995-07-25
DK0506778T3 (da) 1996-10-07
IL96636A (en) 1994-11-28
HU9202044D0 (en) 1992-09-28
DE69027221D1 (de) 1996-07-04
SK658190A3 (en) 1996-08-07
PL288409A1 (en) 1991-12-02
US5227389A (en) 1993-07-13
SI9012346B (sl) 1999-08-31
BG60912B1 (bg) 1996-06-28
NZ236293A (en) 1992-10-28
SK278283B6 (en) 1996-08-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee