EA199800477A1 - Производные хинолина - Google Patents

Производные хинолина

Info

Publication number
EA199800477A1
EA199800477A1 EA199800477A EA199800477A EA199800477A1 EA 199800477 A1 EA199800477 A1 EA 199800477A1 EA 199800477 A EA199800477 A EA 199800477A EA 199800477 A EA199800477 A EA 199800477A EA 199800477 A1 EA199800477 A1 EA 199800477A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
formula
optionally substituted
quinoline derivatives
group
Prior art date
Application number
EA199800477A
Other languages
English (en)
Other versions
EA002124B1 (ru
Inventor
Джузеппе Арнальдо Мария Гьярдина
Марио Груни
Лука Франческо Равелиа
Карло Фарина
Original Assignee
Смитклайн Бичам С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952461 external-priority patent/IT1276170B1/it
Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it
Application filed by Смитклайн Бичам С.П.А. filed Critical Смитклайн Бичам С.П.А.
Publication of EA199800477A1 publication Critical patent/EA199800477A1/ru
Publication of EA002124B1 publication Critical patent/EA002124B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (I)или его сольвату или соли, где Ar представляет собой необязательно замещенный арил, или Сциклоалкдиенильную группу, или необязательно замещенную ароматическую группу с одним бензольным кольцом или конденсированным кольцом; R, R, Rи Rимеют значения, указанные в описании; способ получения этого соединения, фармацевтическая композиция, содержащая соединение формулы (I), или применение соединения или композиции в медицине.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800477A 1995-11-24 1996-11-22 Производные хинолина EA002124B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI952461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
IT96MI001689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici
PCT/EP1996/005203 WO1997021680A1 (en) 1995-11-24 1996-11-22 Quinoline derivatives

Publications (2)

Publication Number Publication Date
EA199800477A1 true EA199800477A1 (ru) 1998-12-24
EA002124B1 EA002124B1 (ru) 2001-12-24

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800477A EA002124B1 (ru) 1995-11-24 1996-11-22 Производные хинолина

Country Status (26)

Country Link
US (1) US6277862B1 (ru)
EP (1) EP0876347B1 (ru)
JP (1) JP2000501104A (ru)
KR (1) KR19990071597A (ru)
CN (1) CN1207730A (ru)
AP (1) AP9801237A0 (ru)
AR (1) AR004972A1 (ru)
AT (1) ATE289994T1 (ru)
BG (1) BG102558A (ru)
BR (1) BR9611820A (ru)
CA (1) CA2238298A1 (ru)
CZ (1) CZ157998A3 (ru)
DE (1) DE69634416T2 (ru)
EA (1) EA002124B1 (ru)
ES (1) ES2236757T3 (ru)
IL (1) IL124522A0 (ru)
MX (1) MX9804107A (ru)
NO (1) NO311212B1 (ru)
NZ (1) NZ323387A (ru)
OA (1) OA11010A (ru)
PL (1) PL326967A1 (ru)
SK (1) SK66798A3 (ru)
TR (1) TR199800924T2 (ru)
TW (1) TW353066B (ru)
UY (1) UY24733A1 (ru)
WO (1) WO1997021680A1 (ru)

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PL170837B1 (pl) 1991-10-18 1997-01-31 Monsanto Co S rod ek g r zybobó j c zy PL PL PL PL PL PL
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
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US7037922B1 (en) * 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
ES2259096T3 (es) * 2001-04-11 2006-09-16 Glaxosmithkline S.P.A. Derivados de quinolina-4-carboxamida 3-sustituida como antagonistas de los receptores nk-3 y nk-2.
AU2002259147A1 (en) * 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1594517B1 (en) 2003-01-28 2007-06-20 Microbia, Inc. Compositions for the treatment of gastrointestinal disorders
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
US20070249670A1 (en) * 2004-11-09 2007-10-25 Smithkline Beecham Corporation Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
CN101282961A (zh) * 2005-08-11 2008-10-08 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的烷基吡啶基喹啉
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW201018662A (en) * 2005-12-12 2010-05-16 Astrazeneca Ab Alkylsulphonamide quinolines
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
BRPI0817445A2 (pt) * 2007-09-28 2015-10-27 Glaxosmithkline Llc composto, composição farmacêutica, método de tratamento, e, processo para preparar um composto
KR20100087300A (ko) * 2007-09-28 2010-08-04 글락소스미스클라인 엘엘씨 글리코겐 포스포릴라아제 억제제 화합물 및 이의 약학적 조성물
EP3239170B1 (en) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
KR101766619B1 (ko) 2008-12-31 2017-08-08 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR102138390B1 (ko) 2012-08-21 2020-07-27 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 ｎｈｅ-매개된 역수송 저해를 위한 화합물 및 방법
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2983667B1 (en) 2013-04-12 2019-03-20 Ardelyx, Inc. Nhe3-binding compounds and methods for inhibiting phosphate transport
EP2986293A1 (en) 2013-04-19 2016-02-24 Astrazeneca AB A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
AU2018206479B2 (en) 2017-01-09 2022-07-14 Ardelyx, Inc. Inhibitors of NHE-mediated antiport
WO2018129552A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders

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FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS63119455A (ja) * 1986-06-27 1988-05-24 Nippon Shinyaku Co Ltd グリシン誘導体
PL186665B1 (pl) * 1994-05-27 2004-02-27 Smithkline Beecham Spa Pochodne chinoliny jako antagoniści receptorów NKtachykininy, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca pochodne chinoliny oraz ich zastosowanie
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
IL124522A0 (en) 1998-12-06
NO982331L (no) 1998-07-22
JP2000501104A (ja) 2000-02-02
US6277862B1 (en) 2001-08-21
MX9804107A (es) 1998-09-30
NO982331D0 (no) 1998-05-22
OA11010A (en) 2003-03-06
PL326967A1 (en) 1998-11-09
EP0876347A1 (en) 1998-11-11
EA002124B1 (ru) 2001-12-24
WO1997021680A1 (en) 1997-06-19
NO311212B1 (no) 2001-10-29
AP9801237A0 (en) 1998-06-30
BG102558A (bg) 1999-03-31
EP0876347B1 (en) 2005-03-02
ATE289994T1 (de) 2005-03-15
ES2236757T3 (es) 2005-07-16
NZ323387A (en) 2000-02-28
KR19990071597A (ko) 1999-09-27
CZ157998A3 (cs) 1998-12-16
TR199800924T2 (xx) 1998-08-21
TW353066B (en) 1999-02-21
UY24733A1 (es) 2001-08-27
DE69634416T2 (de) 2005-12-29
DE69634416D1 (de) 2005-04-07
AR004972A1 (es) 1999-04-07
BR9611820A (pt) 1999-07-13
CN1207730A (zh) 1999-02-10
CA2238298A1 (en) 1997-06-19
SK66798A3 (en) 1999-01-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU