IL124522A0 - Quinoline derivatives - Google Patents
Quinoline derivativesInfo
- Publication number
- IL124522A0 IL124522A0 IL12452296A IL12452296A IL124522A0 IL 124522 A0 IL124522 A0 IL 124522A0 IL 12452296 A IL12452296 A IL 12452296A IL 12452296 A IL12452296 A IL 12452296A IL 124522 A0 IL124522 A0 IL 124522A0
- Authority
- IL
- Israel
- Prior art keywords
- quinoline derivatives
- quinoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002461 IT1276170B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
| IT96MI001689 IT1307331B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
| PCT/EP1996/005203 WO1997021680A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL124522A0 true IL124522A0 (en) | 1998-12-06 |
Family
ID=26331326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12452296A IL124522A0 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277862B1 (xx) |
| EP (1) | EP0876347B1 (xx) |
| JP (1) | JP2000501104A (xx) |
| KR (1) | KR19990071597A (xx) |
| CN (1) | CN1207730A (xx) |
| AP (1) | AP9801237A0 (xx) |
| AR (1) | AR004972A1 (xx) |
| AT (1) | ATE289994T1 (xx) |
| BG (1) | BG102558A (xx) |
| BR (1) | BR9611820A (xx) |
| CA (1) | CA2238298A1 (xx) |
| CZ (1) | CZ157998A3 (xx) |
| DE (1) | DE69634416T2 (xx) |
| EA (1) | EA002124B1 (xx) |
| ES (1) | ES2236757T3 (xx) |
| IL (1) | IL124522A0 (xx) |
| MX (1) | MX9804107A (xx) |
| NO (1) | NO311212B1 (xx) |
| NZ (1) | NZ323387A (xx) |
| OA (1) | OA11010A (xx) |
| PL (1) | PL326967A1 (xx) |
| SK (1) | SK66798A3 (xx) |
| TR (1) | TR199800924T2 (xx) |
| TW (1) | TW353066B (xx) |
| UY (1) | UY24733A1 (xx) |
| WO (1) | WO1997021680A1 (xx) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU219131B (hu) * | 1991-10-18 | 2001-02-28 | Monsanto Co. | Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok |
| SE9703407D0 (sv) * | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
| SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
| GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US7037922B1 (en) * | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| EP1165542B1 (en) | 1999-03-29 | 2003-08-20 | Neurogen Corporation | 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands |
| AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| ATE313539T1 (de) * | 2001-04-11 | 2006-01-15 | Glaxosmithkline Spa | Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten |
| WO2002089802A2 (en) * | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CN100589839C (zh) | 2003-01-28 | 2010-02-17 | 艾恩伍德医药品股份有限公司 | 多肽及包含多肽的药物组合物 |
| GB0303086D0 (en) | 2003-02-11 | 2003-03-19 | Merck Sharp & Dohme | New compounds |
| GB0419192D0 (en) | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
| JP2008519761A (ja) * | 2004-11-09 | 2008-06-12 | スミスクライン ビーチャム コーポレーション | グリコーゲンホスホリラーゼ阻害化合物およびその医薬組成物 |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| JP2009504641A (ja) * | 2005-08-11 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | Ｎｋ−３受容体の調節剤としてのアルキルピリジルキノリン |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2197845A1 (en) * | 2007-09-28 | 2010-06-23 | GlaxoSmithKline LLC | Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof |
| EP2195287A1 (en) * | 2007-09-28 | 2010-06-16 | GlaxoSmithKline LLC | Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| HUE036405T2 (hu) | 2008-12-31 | 2018-07-30 | Ardelyx Inc | Vegyületek és módszerek az NHE-közvetített (Na+/H+ cserével mûködõ) antiport gátlására folyadékretencióval vagy túlzott sómennyiség jelenlétével és a gyomor-bél traktus zavaraival összefüggõ rendellenességek kezelésében |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2880338A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| SI2983667T1 (sl) | 2013-04-12 | 2019-09-30 | Ardelyx, Inc. | Spojine za vezavo NHE3 in metode za zaviranje transporta fosfata |
| EP2986293A1 (en) | 2013-04-19 | 2016-02-24 | Astrazeneca AB | A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos) |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
| EP3565808A1 (en) | 2017-01-09 | 2019-11-13 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| US11147884B2 (en) | 2017-01-09 | 2021-10-19 | Ardelyx, Inc. | Inhibitors of NHE-mediated antiport |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
| JPS6399057A (ja) * | 1986-06-27 | 1988-04-30 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
| ES2227769T3 (es) * | 1994-05-27 | 2005-04-01 | Glaxosmithkline S.P.A. | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-22 AP APAP/P/1998/001237A patent/AP9801237A0/en unknown
- 1996-11-22 NZ NZ323387A patent/NZ323387A/en unknown
- 1996-11-22 DE DE69634416T patent/DE69634416T2/de not_active Expired - Fee Related
- 1996-11-22 BR BR9611820A patent/BR9611820A/pt not_active Application Discontinuation
- 1996-11-22 EP EP96941023A patent/EP0876347B1/en not_active Expired - Lifetime
- 1996-11-22 KR KR1019980703873A patent/KR19990071597A/ko not_active Application Discontinuation
- 1996-11-22 JP JP9521658A patent/JP2000501104A/ja active Pending
- 1996-11-22 EA EA199800477A patent/EA002124B1/ru not_active IP Right Cessation
- 1996-11-22 IL IL12452296A patent/IL124522A0/xx unknown
- 1996-11-22 WO PCT/EP1996/005203 patent/WO1997021680A1/en not_active Application Discontinuation
- 1996-11-22 CA CA002238298A patent/CA2238298A1/en not_active Abandoned
- 1996-11-22 SK SK667-98A patent/SK66798A3/sk unknown
- 1996-11-22 CN CN96199753A patent/CN1207730A/zh active Pending
- 1996-11-22 ES ES96941023T patent/ES2236757T3/es not_active Expired - Lifetime
- 1996-11-22 AT AT96941023T patent/ATE289994T1/de not_active IP Right Cessation
- 1996-11-22 TR TR1998/00924T patent/TR199800924T2/xx unknown
- 1996-11-22 CZ CZ981579A patent/CZ157998A3/cs unknown
- 1996-11-22 PL PL96326967A patent/PL326967A1/xx unknown
- 1996-11-22 US US09/077,151 patent/US6277862B1/en not_active Expired - Fee Related
- 1996-11-23 TW TW085114500A patent/TW353066B/zh active
- 1996-11-25 AR ARP960105317A patent/AR004972A1/es not_active Application Discontinuation
-
1997
- 1997-09-30 UY UY24733A patent/UY24733A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 OA OA9800061A patent/OA11010A/en unknown
- 1998-05-22 NO NO19982331A patent/NO311212B1/no unknown
- 1998-05-22 MX MX9804107A patent/MX9804107A/es unknown
- 1998-06-18 BG BG102558A patent/BG102558A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK66798A3 (en) | 1999-01-11 |
| UY24733A1 (es) | 2001-08-27 |
| MX9804107A (es) | 1998-09-30 |
| ES2236757T3 (es) | 2005-07-16 |
| CN1207730A (zh) | 1999-02-10 |
| NZ323387A (en) | 2000-02-28 |
| OA11010A (en) | 2003-03-06 |
| BG102558A (bg) | 1999-03-31 |
| DE69634416T2 (de) | 2005-12-29 |
| EP0876347A1 (en) | 1998-11-11 |
| EP0876347B1 (en) | 2005-03-02 |
| TR199800924T2 (xx) | 1998-08-21 |
| US6277862B1 (en) | 2001-08-21 |
| ATE289994T1 (de) | 2005-03-15 |
| JP2000501104A (ja) | 2000-02-02 |
| AR004972A1 (es) | 1999-04-07 |
| AP9801237A0 (en) | 1998-06-30 |
| NO982331L (no) | 1998-07-22 |
| NO311212B1 (no) | 2001-10-29 |
| PL326967A1 (en) | 1998-11-09 |
| CA2238298A1 (en) | 1997-06-19 |
| BR9611820A (pt) | 1999-07-13 |
| WO1997021680A1 (en) | 1997-06-19 |
| EA199800477A1 (ru) | 1998-12-24 |
| CZ157998A3 (cs) | 1998-12-16 |
| EA002124B1 (ru) | 2001-12-24 |
| TW353066B (en) | 1999-02-21 |
| KR19990071597A (ko) | 1999-09-27 |
| DE69634416D1 (de) | 2005-04-07 |
| NO982331D0 (no) | 1998-05-22 |
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