MX9804107A - Derivados de quinolina. - Google Patents

Derivados de quinolina.

Info

Publication number
MX9804107A
MX9804107A MX9804107A MX9804107A MX9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A MX 9804107 A MX9804107 A MX 9804107A
Authority
MX
Mexico
Prior art keywords
compound
quinoline derivatives
optionally substituted
group
solvate
Prior art date
Application number
MX9804107A
Other languages
English (en)
Inventor
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Luca Francesco Raveglia
Carlo Farino
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952461 external-priority patent/IT1276170B1/it
Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of MX9804107A publication Critical patent/MX9804107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

Un compuesto o solvato o sal del mismo de la formula (Ver Formula) en donde a R es un grupo arilo opcionalmente substituido o un grupo cicloalcadienilo de C5-7, o un grupo heterocíclico aromático de anillo individual o funcionado opcionalmente substituido; R, R1, R2 y R3 son como se define en la descripcion; un procedimiento para la preparacion dicho compuesto, una composicion farmacéutica que contiene un compuesto o composicion en medicina.
MX9804107A 1995-11-24 1998-05-22 Derivados de quinolina. MX9804107A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI952461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
IT96MI001689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici

Publications (1)

Publication Number Publication Date
MX9804107A true MX9804107A (es) 1998-09-30

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804107A MX9804107A (es) 1995-11-24 1998-05-22 Derivados de quinolina.

Country Status (26)

Country Link
US (1) US6277862B1 (es)
EP (1) EP0876347B1 (es)
JP (1) JP2000501104A (es)
KR (1) KR19990071597A (es)
CN (1) CN1207730A (es)
AP (1) AP9801237A0 (es)
AR (1) AR004972A1 (es)
AT (1) ATE289994T1 (es)
BG (1) BG102558A (es)
BR (1) BR9611820A (es)
CA (1) CA2238298A1 (es)
CZ (1) CZ157998A3 (es)
DE (1) DE69634416T2 (es)
EA (1) EA002124B1 (es)
ES (1) ES2236757T3 (es)
IL (1) IL124522A0 (es)
MX (1) MX9804107A (es)
NO (1) NO311212B1 (es)
NZ (1) NZ323387A (es)
OA (1) OA11010A (es)
PL (1) PL326967A1 (es)
SK (1) SK66798A3 (es)
TR (1) TR199800924T2 (es)
TW (1) TW353066B (es)
UY (1) UY24733A1 (es)
WO (1) WO1997021680A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219131B (hu) * 1991-10-18 2001-02-28 Monsanto Co. Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) * 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
CA2368455A1 (en) 1999-03-29 2000-10-05 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
JP2004525184A (ja) * 2001-04-11 2004-08-19 グラクソスミスクライン・ソシエタ・ペル・アチオニ Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体
AU2002259147A1 (en) * 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05008097A (es) 2003-01-28 2006-02-08 Microbia Inc Metodos y composiciones para el tratamiento de desordenes gastrointestinales.
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
US20070249670A1 (en) * 2004-11-09 2007-10-25 Smithkline Beecham Corporation Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
WO2007018466A1 (en) * 2005-08-11 2007-02-15 Astrazeneca Ab Alkylpyridyl quinolines as nk3 receptor modulators
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) * 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
KR20100087300A (ko) * 2007-09-28 2010-08-04 글락소스미스클라인 엘엘씨 글리코겐 포스포릴라아제 억제제 화합물 및 이의 약학적 조성물
CN101861303A (zh) * 2007-09-28 2010-10-13 葛兰素史密丝克莱恩有限责任公司 糖原磷酸化酶抑制剂化合物和其药物组合物
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
MX345283B (es) 2008-12-31 2017-01-24 Ardelyx Inc Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2880338A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
KR20230132619A (ko) 2013-04-12 2023-09-15 알데릭스, 인코포레이티드 Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법
EP2986293A1 (en) 2013-04-19 2016-02-24 Astrazeneca AB A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
CA3049679A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibitors of nhe-mediated antiport
JP7292207B2 (ja) 2017-01-09 2023-06-16 アルデリックス， インコーポレイテッド 消化管障害を処置するために有用な化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6399057A (ja) * 1986-06-27 1988-04-30 Nippon Shinyaku Co Ltd グリシン誘導体
NZ287442A (en) * 1994-05-27 1998-05-27 Smithkline Beecham Spa 4-substituted quinoline derivatives; medicaments; use as an nk3 receptor antagonist
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
ES2236757T3 (es) 2005-07-16
EP0876347A1 (en) 1998-11-11
NO311212B1 (no) 2001-10-29
CZ157998A3 (cs) 1998-12-16
WO1997021680A1 (en) 1997-06-19
TW353066B (en) 1999-02-21
DE69634416T2 (de) 2005-12-29
CN1207730A (zh) 1999-02-10
NO982331L (no) 1998-07-22
JP2000501104A (ja) 2000-02-02
DE69634416D1 (de) 2005-04-07
US6277862B1 (en) 2001-08-21
EA199800477A1 (ru) 1998-12-24
NZ323387A (en) 2000-02-28
EP0876347B1 (en) 2005-03-02
EA002124B1 (ru) 2001-12-24
CA2238298A1 (en) 1997-06-19
ATE289994T1 (de) 2005-03-15
IL124522A0 (en) 1998-12-06
TR199800924T2 (xx) 1998-08-21
AP9801237A0 (en) 1998-06-30
KR19990071597A (ko) 1999-09-27
PL326967A1 (en) 1998-11-09
BG102558A (bg) 1999-03-31
NO982331D0 (no) 1998-05-22
BR9611820A (pt) 1999-07-13
SK66798A3 (en) 1999-01-11
OA11010A (en) 2003-03-06
UY24733A1 (es) 2001-08-27
AR004972A1 (es) 1999-04-07

Similar Documents

Publication Publication Date Title
MX9804107A (es) Derivados de quinolina.
DE3854454D1 (de) Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung.
IL93050A0 (en) Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ275647A (en) Tricyclic amide and urea derivatives and medicaments
HU906402D0 (en) Process for producing tricyclic carbapeneme derivatives an pharmaceutical preparatives containing these compounds as active substance
DE3581566D1 (de) Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
CA2136553A1 (en) 7-(2-aminoethyl)-Benzothiazolones
AU3620597A (en) Indole derivatives for the treatment of osteoporosis
HUT45538A (en) Process for producing quinoline derivatives and pharmaceutical compositions containing them
ATE48001T1 (de) Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
AU7414691A (en) New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them
IL108085A0 (en) Serotoninergic ergoline derivatives their preparation and pharmacutical compositions containing them
ES8606880A1 (es) Un procedimiento para la preparacion de nuevos peptidos.
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
AU4583489A (en) New indole derivatives, process for preparing them and pharmaceutical compositions containing them
NO174886C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrrolidin-derivater
WO1987004435A3 (en) Xanthine compounds
AU585418B2 (en) 6H-isoxazolo`` 3,4-d`` pyrazolo`` 3,4-b`` pyridines,a process for their preparation and their use as medicaments