BG102558A - Хинолинови производни - Google Patents
Хинолинови производни Download PDFInfo
- Publication number
- BG102558A BG102558A BG102558A BG10255898A BG102558A BG 102558 A BG102558 A BG 102558A BG 102558 A BG102558 A BG 102558A BG 10255898 A BG10255898 A BG 10255898A BG 102558 A BG102558 A BG 102558A
- Authority
- BG
- Bulgaria
- Prior art keywords
- formula
- compound
- alkyl
- group
- alkylcarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI952461 IT1276170B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
ITMI961689 IT1307331B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
PCT/EP1996/005203 WO1997021680A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BG102558A true BG102558A (bg) | 1999-03-31 |
Family
ID=26331326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102558A BG102558A (bg) | 1995-11-24 | 1998-06-18 | Хинолинови производни |
Country Status (26)
Country | Link |
---|---|
US (1) | US6277862B1 (xx) |
EP (1) | EP0876347B1 (xx) |
JP (1) | JP2000501104A (xx) |
KR (1) | KR19990071597A (xx) |
CN (1) | CN1207730A (xx) |
AP (1) | AP9801237A0 (xx) |
AR (1) | AR004972A1 (xx) |
AT (1) | ATE289994T1 (xx) |
BG (1) | BG102558A (xx) |
BR (1) | BR9611820A (xx) |
CA (1) | CA2238298A1 (xx) |
CZ (1) | CZ157998A3 (xx) |
DE (1) | DE69634416T2 (xx) |
EA (1) | EA002124B1 (xx) |
ES (1) | ES2236757T3 (xx) |
IL (1) | IL124522A0 (xx) |
MX (1) | MX9804107A (xx) |
NO (1) | NO311212B1 (xx) |
NZ (1) | NZ323387A (xx) |
OA (1) | OA11010A (xx) |
PL (1) | PL326967A1 (xx) |
SK (1) | SK66798A3 (xx) |
TR (1) | TR199800924T2 (xx) |
TW (1) | TW353066B (xx) |
UY (1) | UY24733A1 (xx) |
WO (1) | WO1997021680A1 (xx) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU219131B (hu) * | 1991-10-18 | 2001-02-28 | Monsanto Co. | Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok |
SE9703407D0 (sv) * | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
JP2002540203A (ja) | 1999-03-29 | 2002-11-26 | ニューロゲン コーポレイション | Nk−3および/またはgaba(a)受容体リガンドとしての4−置換キノリン誘導体 |
WO2000064877A1 (en) | 1999-04-26 | 2000-11-02 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
DE60209362T2 (de) * | 2001-04-11 | 2006-10-26 | Glaxosmithkline S.P.A. | 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten |
WO2002089802A2 (en) * | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
ES2350123T3 (es) | 2003-01-28 | 2011-01-18 | Ironwood Pharmaceuticals, Inc. | Composiciones para el tratamiento de trastornos gastrointestinales. |
GB0303086D0 (en) | 2003-02-11 | 2003-03-19 | Merck Sharp & Dohme | New compounds |
GB0419192D0 (en) | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
US20070249670A1 (en) * | 2004-11-09 | 2007-10-25 | Smithkline Beecham Corporation | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof |
GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
CN101282961A (zh) * | 2005-08-11 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 作为nk3受体调节剂的烷基吡啶基喹啉 |
AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
TW200804288A (en) | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
CN101932557A (zh) * | 2007-09-28 | 2010-12-29 | 葛兰素史密丝克莱恩有限责任公司 | 糖原磷酸化酶抑制剂化合物及其药物组合物 |
EA201000392A1 (ru) * | 2007-09-28 | 2010-10-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Соединение, представляющее собой ингибитор гликогенфосфорилазы, и его фармацевтическая композиция |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
WO2010078449A2 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2887964B1 (en) | 2012-08-21 | 2019-07-03 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
SI2983667T1 (sl) | 2013-04-12 | 2019-09-30 | Ardelyx, Inc. | Spojine za vezavo NHE3 in metode za zaviranje transporta fosfata |
CA2909752A1 (en) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos) |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
JP7292207B2 (ja) | 2017-01-09 | 2023-06-16 | アルデリックス, インコーポレイテッド | 消化管障害を処置するために有用な化合物 |
CA3049679A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
JPS6399057A (ja) * | 1986-06-27 | 1988-04-30 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
ES2227769T3 (es) * | 1994-05-27 | 2005-04-01 | Glaxosmithkline S.P.A. | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-22 IL IL12452296A patent/IL124522A0/xx unknown
- 1996-11-22 CN CN96199753A patent/CN1207730A/zh active Pending
- 1996-11-22 AP APAP/P/1998/001237A patent/AP9801237A0/en unknown
- 1996-11-22 ES ES96941023T patent/ES2236757T3/es not_active Expired - Lifetime
- 1996-11-22 US US09/077,151 patent/US6277862B1/en not_active Expired - Fee Related
- 1996-11-22 SK SK667-98A patent/SK66798A3/sk unknown
- 1996-11-22 NZ NZ323387A patent/NZ323387A/en unknown
- 1996-11-22 CA CA002238298A patent/CA2238298A1/en not_active Abandoned
- 1996-11-22 CZ CZ981579A patent/CZ157998A3/cs unknown
- 1996-11-22 BR BR9611820A patent/BR9611820A/pt not_active Application Discontinuation
- 1996-11-22 EA EA199800477A patent/EA002124B1/ru not_active IP Right Cessation
- 1996-11-22 EP EP96941023A patent/EP0876347B1/en not_active Expired - Lifetime
- 1996-11-22 AT AT96941023T patent/ATE289994T1/de not_active IP Right Cessation
- 1996-11-22 KR KR1019980703873A patent/KR19990071597A/ko not_active Application Discontinuation
- 1996-11-22 DE DE69634416T patent/DE69634416T2/de not_active Expired - Fee Related
- 1996-11-22 WO PCT/EP1996/005203 patent/WO1997021680A1/en not_active Application Discontinuation
- 1996-11-22 PL PL96326967A patent/PL326967A1/xx unknown
- 1996-11-22 JP JP9521658A patent/JP2000501104A/ja active Pending
- 1996-11-22 TR TR1998/00924T patent/TR199800924T2/xx unknown
- 1996-11-23 TW TW085114500A patent/TW353066B/zh active
- 1996-11-25 AR ARP960105317A patent/AR004972A1/es not_active Application Discontinuation
-
1997
- 1997-09-30 UY UY24733A patent/UY24733A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 OA OA9800061A patent/OA11010A/en unknown
- 1998-05-22 MX MX9804107A patent/MX9804107A/es unknown
- 1998-05-22 NO NO19982331A patent/NO311212B1/no unknown
- 1998-06-18 BG BG102558A patent/BG102558A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
OA11010A (en) | 2003-03-06 |
US6277862B1 (en) | 2001-08-21 |
MX9804107A (es) | 1998-09-30 |
EP0876347B1 (en) | 2005-03-02 |
AP9801237A0 (en) | 1998-06-30 |
EA199800477A1 (ru) | 1998-12-24 |
TR199800924T2 (xx) | 1998-08-21 |
CN1207730A (zh) | 1999-02-10 |
DE69634416D1 (de) | 2005-04-07 |
EA002124B1 (ru) | 2001-12-24 |
NO982331L (no) | 1998-07-22 |
SK66798A3 (en) | 1999-01-11 |
IL124522A0 (en) | 1998-12-06 |
CA2238298A1 (en) | 1997-06-19 |
TW353066B (en) | 1999-02-21 |
PL326967A1 (en) | 1998-11-09 |
JP2000501104A (ja) | 2000-02-02 |
EP0876347A1 (en) | 1998-11-11 |
KR19990071597A (ko) | 1999-09-27 |
AR004972A1 (es) | 1999-04-07 |
DE69634416T2 (de) | 2005-12-29 |
NZ323387A (en) | 2000-02-28 |
NO982331D0 (no) | 1998-05-22 |
CZ157998A3 (cs) | 1998-12-16 |
ES2236757T3 (es) | 2005-07-16 |
BR9611820A (pt) | 1999-07-13 |
NO311212B1 (no) | 2001-10-29 |
WO1997021680A1 (en) | 1997-06-19 |
UY24733A1 (es) | 2001-08-27 |
ATE289994T1 (de) | 2005-03-15 |
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