ES2087280T3 - 4-fenil-4-piperidina-carboxamidas sustituidas con efecto tanto anestesico local como analgesico, asi como procedimientos para su preparacion. - Google Patents

4-fenil-4-piperidina-carboxamidas sustituidas con efecto tanto anestesico local como analgesico, asi como procedimientos para su preparacion.

Info

Publication number
ES2087280T3
ES2087280T3 ES91901571T ES91901571T ES2087280T3 ES 2087280 T3 ES2087280 T3 ES 2087280T3 ES 91901571 T ES91901571 T ES 91901571T ES 91901571 T ES91901571 T ES 91901571T ES 2087280 T3 ES2087280 T3 ES 2087280T3
Authority
ES
Spain
Prior art keywords
preparation
phenyl
well
analgesic
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901571T
Other languages
English (en)
Inventor
Anna-Lena Ask
Rune Sandberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2087280T3 publication Critical patent/ES2087280T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)

Abstract

4-FENIL-4-PIPERIDINCARBOXAMIDAS SUSTITUIDAS CON EFECTO TANTO ANESTESICO COMO ANALGESICO LOCAL ASI COMO LOS PROCESOS PARA SU PREPARACION COMPUESTOS DE LA FORMULA (IV) PARA USARLOS COMO ANESTESICOS Y ANALGESICOS LOCALES, ASI COMO UN METODO PARA SU PREPARACION, SUS PREPARACIONES FARMACEUTICAS Y SU USO.
ES91901571T 1989-12-21 1990-12-17 4-fenil-4-piperidina-carboxamidas sustituidas con efecto tanto anestesico local como analgesico, asi como procedimientos para su preparacion. Expired - Lifetime ES2087280T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds

Publications (1)

Publication Number Publication Date
ES2087280T3 true ES2087280T3 (es) 1996-07-16

Family

ID=20377821

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901571T Expired - Lifetime ES2087280T3 (es) 1989-12-21 1990-12-17 4-fenil-4-piperidina-carboxamidas sustituidas con efecto tanto anestesico local como analgesico, asi como procedimientos para su preparacion.

Country Status (40)

Country Link
US (2) US5227389A (es)
EP (1) EP0506778B1 (es)
JP (1) JP2656152B2 (es)
KR (1) KR0179382B1 (es)
CN (1) CN1037841C (es)
AT (1) ATE138650T1 (es)
AU (1) AU647068B2 (es)
BG (1) BG60912B1 (es)
BR (1) BR1100379A (es)
CA (1) CA2069608C (es)
CZ (1) CZ278035B6 (es)
DE (1) DE69027221T2 (es)
DK (1) DK0506778T3 (es)
DZ (1) DZ1468A1 (es)
EG (1) EG19361A (es)
ES (1) ES2087280T3 (es)
FI (1) FI100881B (es)
HK (1) HK22997A (es)
HR (1) HRP920591B1 (es)
HU (1) HU213110B (es)
IE (1) IE74855B1 (es)
IL (1) IL96636A (es)
IS (1) IS1664B (es)
LT (1) LT4005B (es)
LV (2) LV10949B (es)
NO (1) NO178858C (es)
NZ (1) NZ236293A (es)
PL (1) PL163591B1 (es)
PT (1) PT96303B (es)
RO (1) RO112864B1 (es)
RU (1) RU2039043C1 (es)
SA (1) SA91110209B1 (es)
SE (1) SE8904298D0 (es)
SG (1) SG46413A1 (es)
SI (1) SI9012346B (es)
SK (1) SK658190A3 (es)
UA (1) UA26403A (es)
WO (1) WO1991009845A1 (es)
YU (1) YU48086B (es)
ZA (1) ZA909903B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
SE9404438D0 (sv) * 1994-12-21 1994-12-21 Astra Ab New process
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) * 1996-01-05 1996-03-06 Pfizer Ltd Therapeutic agents
DE19642591A1 (de) * 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
RU2125878C1 (ru) * 1996-12-26 1999-02-10 Новокузнецкий научно-исследовательский химико-фармацевтический институт Анальгетическое средство
RU2117481C1 (ru) * 1997-07-15 1998-08-20 Государственный научно-исследовательский институт органической химии и технологии Анальгетическое средство и способ его приготовления
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US20020102291A1 (en) * 1997-12-15 2002-08-01 Noven Pharmaceuticals, Inc. Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803239D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
JP4280073B2 (ja) * 2001-04-12 2009-06-17 ファーマコペイア ドラッグ ディスカバリー， インコーポレイテッド Ｍｃｈアンタゴニストとして使用されるアリールピペリジンおよびビアリールピペリジン
RU2203041C1 (ru) * 2001-12-27 2003-04-27 Закрытое акционерное общество "Брынцалов-А" Спазмолитические таблетки бралангин
ES2356306T3 (es) * 2002-02-08 2011-04-06 Ono Pharmaceutical Co., Ltd. Compuestos y fármacos derivados de piperidina que contienen los compuestos como principio activo.
AU2003300902A1 (en) * 2002-12-13 2004-07-09 Smithkline Beecham Corporation Piperidine derivatives as CCR5 antagonists
WO2008045564A2 (en) * 2006-10-12 2008-04-17 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
BRPI0820701A2 (pt) 2007-12-11 2015-06-16 Cytopathfinder Inc Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20220096452A1 (en) 2019-01-22 2022-03-31 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE96980C1 (es)
US2486796A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) * 1964-10-20 1967-08-01 Aldrich Chem Co Inc N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) * 1967-06-26 1970-11-10 Janssen Pharm 4-aryl-4-aminoalkoxy-piperidines
CH498836A (de) * 1968-12-20 1970-11-15 Geigy Ag J R Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) * 1968-12-30 1973-06-05 Ciba Geigy Corp Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) * 1971-10-21 1973-06-01 Synthelabo 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
DZ1468A1 (fr) 2004-09-13
SK278283B6 (en) 1996-08-07
WO1991009845A1 (en) 1991-07-11
CA2069608A1 (en) 1991-06-22
HRP920591B1 (en) 1998-12-31
KR0179382B1 (ko) 1999-03-20
PT96303B (pt) 1998-07-31
YU234690A (sh) 1993-10-20
ZA909903B (en) 1991-08-28
LT4005B (en) 1996-07-25
NZ236293A (en) 1992-10-28
SE8904298D0 (sv) 1989-12-21
EP0506778A1 (en) 1992-10-07
US5227389A (en) 1993-07-13
CA2069608C (en) 2001-07-10
SG46413A1 (en) 1998-02-20
CN1053605A (zh) 1991-08-07
HU213110B (en) 1997-02-28
JPH05502869A (ja) 1993-05-20
FI922806A0 (fi) 1992-06-17
DK0506778T3 (da) 1996-10-07
JP2656152B2 (ja) 1997-09-24
NO178858B (no) 1996-03-11
EG19361A (en) 1994-12-30
EP0506778B1 (en) 1996-05-29
BR1100379A (pt) 1999-12-07
RU2039043C1 (ru) 1995-07-09
DE69027221T2 (de) 1996-10-10
IS3659A7 (is) 1991-06-22
SI9012346B (sl) 1999-08-31
HUT64518A (en) 1994-01-28
BG96513A (bg) 1993-12-24
YU48086B (sh) 1997-01-08
SA91110209B1 (ar) 2004-05-08
PL288409A1 (en) 1991-12-02
LV10949B (en) 1996-06-20
NO922380L (no) 1992-06-17
SI9012346A (sl) 1998-08-31
PL163591B1 (pl) 1994-04-29
PT96303A (pt) 1991-09-30
CZ658190A3 (en) 1993-01-13
LV5766B4 (lv) 1997-06-20
IE904534A1 (en) 1991-07-03
NO178858C (no) 1996-06-19
CZ278035B6 (en) 1993-07-14
CN1037841C (zh) 1998-03-25
IL96636A (en) 1994-11-28
ATE138650T1 (de) 1996-06-15
IS1664B (is) 1997-07-04
AU647068B2 (en) 1994-03-17
HK22997A (en) 1997-02-27
US5360805A (en) 1994-11-01
AU6978391A (en) 1991-07-24
NO922380D0 (no) 1992-06-17
HRP920591A2 (en) 1997-08-31
HU9202044D0 (en) 1992-09-28
LTIP1731A (en) 1995-07-25
BG60912B1 (bg) 1996-06-28
LV5766A4 (lv) 1996-12-20
IE74855B1 (en) 1997-08-13
IL96636A0 (en) 1991-09-16
UA26403A (uk) 1999-08-30
DE69027221D1 (de) 1996-07-04
LV10949A (lv) 1995-12-20
SK658190A3 (en) 1996-08-07
RO112864B1 (ro) 1998-01-30
FI922806L (fi) 1992-06-17
FI100881B (fi) 1998-03-13
KR927003531A (ko) 1992-12-18

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