ES2058070T3 - Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. - Google Patents

Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos.

Info

Publication number
ES2058070T3
ES2058070T3 ES87105548T ES87105548T ES2058070T3 ES 2058070 T3 ES2058070 T3 ES 2058070T3 ES 87105548 T ES87105548 T ES 87105548T ES 87105548 T ES87105548 T ES 87105548T ES 2058070 T3 ES2058070 T3 ES 2058070T3
Authority
ES
Spain
Prior art keywords
preparation
malignant tumors
medicinal product
prevent metastasis
specific monosaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87105548T
Other languages
English (en)
Inventor
Gerhard Prof Dr Dr H Pulverer
Kurt Prof Dr Med Oette
Gerd Prof Dr Med Uhlenbruck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2058070T3 publication Critical patent/ES2058070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid Fuels And Fuel-Associated Substances (AREA)

Abstract

MEDIOS Y PROCEDIMIENTO PARA EVITAR LAS METASTASIS DE LOS TUMORES MALIGNOS, CON LA UTILIZACION DE MONOSACARIDOS ESPECIFICOS PARA ORGANOCELULOLECTINA, Y/O PREFERENTEMENTE LOS GLICOCONJUGADOS RESULTANTES, CONTENIENDO ESTOS MONOSACARIDOS, ESPECIALMENTE LA (BETA) OS, QUE CONTIENEN (BETA) - D - GALACTOSA.
ES87105548T 1986-05-09 1987-04-14 Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. Expired - Lifetime ES2058070T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3615621 1986-05-09

Publications (1)

Publication Number Publication Date
ES2058070T3 true ES2058070T3 (es) 1994-11-01

Family

ID=6300445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87105548T Expired - Lifetime ES2058070T3 (es) 1986-05-09 1987-04-14 Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos.

Country Status (6)

Country Link
US (1) US4946830A (es)
EP (1) EP0249008B1 (es)
JP (1) JPH07100658B2 (es)
AT (1) ATE94395T1 (es)
DE (1) DE3787403D1 (es)
ES (1) ES2058070T3 (es)

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US7060685B2 (en) * 2002-05-16 2006-06-13 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
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US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
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US7361644B2 (en) * 2003-11-19 2008-04-22 Glycomimetics, Inc. Specific antagonist for both E- and P-selectins
CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
EP1718146A2 (en) * 2004-02-13 2006-11-08 Pro-Pharmaceuticals, Inc. Compositions and methods used to treat acne and candida
JP2007529554A (ja) * 2004-03-19 2007-10-25 プロ−ファーマシューティカルズ，インク． 多価リガンド結合糖質ポリマーを用いた組成物、および該組成物による転移腫瘍の標的療法
US20080286251A1 (en) * 2004-08-02 2008-11-20 Propharmaceuticals, Inc. Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
AU2006280101B2 (en) * 2005-08-09 2012-06-28 Glycomimetics, Inc. Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
US7728117B2 (en) * 2005-09-02 2010-06-01 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
WO2008060378A2 (en) * 2006-10-12 2008-05-22 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
CA2677747A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) * 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
EP2318015B1 (en) * 2008-06-13 2013-08-07 GlycoMimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) * 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US9109002B2 (en) 2011-12-22 2015-08-18 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
PT2928476T (pt) 2012-12-07 2018-05-10 Glycomimetics Inc Compostos, composições e métodos que utilizam antagonistas de e-selectina para mobilização de células hematopoiéticas
US10519181B2 (en) 2014-12-03 2019-12-31 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
JP2019524791A (ja) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ
CN117298287A (zh) 2016-10-07 2023-12-29 糖模拟物有限公司 高效的多聚体e-选择蛋白拮抗剂
WO2018169853A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
WO2019133878A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

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Also Published As

Publication number Publication date
ATE94395T1 (de) 1993-10-15
JPS62267234A (ja) 1987-11-19
JPH07100658B2 (ja) 1995-11-01
EP0249008A3 (en) 1989-09-27
EP0249008B1 (de) 1993-09-15
US4946830A (en) 1990-08-07
DE3787403D1 (de) 1993-10-21
EP0249008A2 (de) 1987-12-16

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