AR058051A1 - Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. - Google Patents

Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas.

Info

Publication number
AR058051A1
AR058051A1 ARP060104048A ARP060104048A AR058051A1 AR 058051 A1 AR058051 A1 AR 058051A1 AR P060104048 A ARP060104048 A AR P060104048A AR P060104048 A ARP060104048 A AR P060104048A AR 058051 A1 AR058051 A1 AR 058051A1
Authority
AR
Argentina
Prior art keywords
alkoxy
alkyl
halogen
occurrence
independently selected
Prior art date
Application number
ARP060104048A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR058051A1 publication Critical patent/AR058051A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Abstract

Métodos para su preparacion, composiciones farmacéuticas que los contienen y métodos para su utilizacion. Reivindicacion 1: Un compuesto de acuerdo con la formula (1) en la cual R1 es cianometilo; A es fenilo o cicloalquil C3-7-; R2 en cada aparicion se selecciona independientemente entre H, -OH, -NH2, -CN, halogeno, alquil C1-6-, cicloalquil C3-7-, alcoxi C1-6- y alcoxi C1-6-alquil C1-6-; n es 1, 2 o 3; R3 en cada aparicion se selecciona independientemente entre H, -OH, -NH2, -NO2, - CN, halogeno, alquil C1-6-, alcoxi C1-6- y alcoxi C1-6-alquil C1-6-; m es 1, 2 o 3; R4 se selecciona entre H, -OH, -OSO2R6, alquil C1-6-, alcoxi C1-6-, alcoxi C1-6-alquil C1-6- y E-(CH2)p-, donde E se selecciona entre -NR6R7, -NR6SO2R7, -N+(O-)R6R7, arilo y un anillo heterocíclico aromático o no aromático de 5 o 6 miembros ligado a N o C con 1, 2, 3 o 4 átomos de N o su N-oxido y p es 0, 1, 2, 3, 4 o 5; R5 en cada aparicion se selecciona independientemente entre H, -OH, -CN, halogeno, -R6, - OR6, -NR6R7, -SR6, -SOR6 y -SO2R6; q es 1, 2 o 3; donde R6 y R7 en cada aparicion se seleccionan independientemente entre H, un grupo alquilo recto o ramificado C1-6, alquenilo o alquinilo recto o ramificado C2-6 y un grupo carbocíclico C3-7 con 0, 1 o 2 enlaces dobles o triples, donde dichos grupos están sin sustituir o están sustituidos con una o más porciones seleccionadas entre -OH, =O, -NH2, -CN, halogeno, arilo y alcoxi C1-3-; y, cuando R2, R3 o R4 es una porcion alquilo C2-6, cicloalquilo, alcoxi o alcoxialquilo, dichas porciones están sin sustituir o tienen 1, 2, 3, 4 o 5 sustituyentes seleccionados en forma independiente en cada aparicion entre -OH, -NH2, -CN, fenilo y halogeno; o su estereoisomero, enantiomero, precursor hidrolizable in vivo o su sal farmacéuticamente aceptable.
ARP060104048A 2005-09-21 2006-09-15 Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. AR058051A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71928605P 2005-09-21 2005-09-21

Publications (1)

Publication Number Publication Date
AR058051A1 true AR058051A1 (es) 2008-01-23

Family

ID=37889113

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104048A AR058051A1 (es) 2005-09-21 2006-09-15 Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas.

Country Status (8)

Country Link
US (1) US20080306110A1 (es)
EP (1) EP1928834A1 (es)
JP (1) JP2009508945A (es)
CN (1) CN101268053A (es)
AR (1) AR058051A1 (es)
TW (1) TW200728284A (es)
UY (1) UY29804A1 (es)
WO (1) WO2007035157A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101189211A (zh) * 2005-06-03 2008-05-28 阿斯利康(瑞典)有限公司 作为nk3拮抗剂的喹啉衍生物
CN101282964A (zh) * 2005-08-11 2008-10-08 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的氧-吡啶基喹啉酰胺
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
US20080234269A1 (en) * 2005-09-21 2008-09-25 Astrazeneca Ab N-Oxo-Heterocycle and N-Oxo-Alkyl Quinoline-4-Carboxamides as Nk-3 Receptor Ligands
TW200804288A (en) * 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
EA021421B1 (ru) 2008-05-23 2015-06-30 Новартис Аг Производные хинолинов и хиноксалинов в качестве ингибиторов протеинтирозинкиназы, способ их получения, содержащая их фармацевтическая композиция и способ лечения заболеваний с применением таких соединений
UY33874A (es) 2011-01-26 2012-08-31 Sanofi Aventis Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69533408T2 (de) * 1994-05-27 2005-09-08 Glaxosmithkline S.P.A. Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
US20080306110A1 (en) 2008-12-11
JP2009508945A (ja) 2009-03-05
WO2007035157A1 (en) 2007-03-29
EP1928834A1 (en) 2008-06-11
CN101268053A (zh) 2008-09-17
UY29804A1 (es) 2007-04-30
TW200728284A (en) 2007-08-01

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