AR065322A1 - 2-aminooxazolinas comoligandos de taar1 - Google Patents
2-aminooxazolinas comoligandos de taar1Info
- Publication number
- AR065322A1 AR065322A1 ARP080100608A ARP080100608A AR065322A1 AR 065322 A1 AR065322 A1 AR 065322A1 AR P080100608 A ARP080100608 A AR P080100608A AR P080100608 A ARP080100608 A AR P080100608A AR 065322 A1 AR065322 A1 AR 065322A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- heteroaryl
- aryl
- halogen
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Abstract
La presente se refiere a compuestos de la formula (1) en la que R1 es arilo o heteroarilo, dichos grupos arilo y heteroarilo pueden estar sin sustituir o sustituidos de una a tres veces por sustituyentes elegidos entre el grupo formado por cicloalquilo, fenilo, feniloxi, bencilo, benciloxi, halogeno, alquilo inferior, alcoxi inferior, heteroarilo, piperidin-1-ilo o por alquilo inferior sustituido por halogeno, o es arilo o heteroarilo, en los que por lo menos un átomo de hidrogeno se ha reemplazado por deuterio o tritio; R2 es hidrogeno, alquilo inferior o es bencilo sin sustituir o sustituido por alcoxi o halogeno; o R1 y R2 junto con el átomo de N al que están unidos forman un 2,3-dihidroindol-1-ilo o 3,4-dihidro-quinolin-1- ilo, R3 es hidrogeno o alquilo inferior; o a las sales de adicion de ácido farmacéuticamente idoneas de los mismos para el tratamiento de trastornos del SNC.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07102429 | 2007-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065322A1 true AR065322A1 (es) | 2009-05-27 |
Family
ID=39577660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100608A AR065322A1 (es) | 2007-02-15 | 2008-02-13 | 2-aminooxazolinas comoligandos de taar1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US7902238B2 (es) |
EP (1) | EP2121641B1 (es) |
JP (1) | JP5130305B2 (es) |
KR (2) | KR101335845B1 (es) |
CN (1) | CN101616902B (es) |
AR (1) | AR065322A1 (es) |
AU (1) | AU2008214774A1 (es) |
BR (1) | BRPI0807813A2 (es) |
CA (1) | CA2676944C (es) |
CL (1) | CL2008000434A1 (es) |
ES (1) | ES2525229T3 (es) |
IL (1) | IL200045A0 (es) |
MX (1) | MX2009008465A (es) |
PE (1) | PE20081783A1 (es) |
RU (1) | RU2460725C2 (es) |
TW (1) | TWI372051B (es) |
WO (1) | WO2008098857A1 (es) |
ZA (1) | ZA200905272B (es) |
Families Citing this family (142)
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RU2010104632A (ru) * | 2007-07-27 | 2011-09-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | 2-азетидинметанамины и 2-пирролидинметанамины в качестве лигандов taar |
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KR101335845B1 (ko) | 2013-12-02 |
CA2676944C (en) | 2016-01-19 |
JP5130305B2 (ja) | 2013-01-30 |
IL200045A0 (en) | 2010-04-15 |
RU2009132189A (ru) | 2011-03-20 |
TW200845968A (en) | 2008-12-01 |
CA2676944A1 (en) | 2008-08-21 |
ZA200905272B (en) | 2010-05-26 |
US20090105307A1 (en) | 2009-04-23 |
PE20081783A1 (es) | 2008-12-18 |
EP2121641A1 (en) | 2009-11-25 |
CN101616902B (zh) | 2013-03-27 |
BRPI0807813A2 (pt) | 2014-08-05 |
WO2008098857A1 (en) | 2008-08-21 |
US7902238B2 (en) | 2011-03-08 |
KR20090104914A (ko) | 2009-10-06 |
MX2009008465A (es) | 2009-08-20 |
KR20120041776A (ko) | 2012-05-02 |
CL2008000434A1 (es) | 2008-08-22 |
ES2525229T3 (es) | 2014-12-19 |
CN101616902A (zh) | 2009-12-30 |
KR101222412B1 (ko) | 2013-01-15 |
RU2460725C2 (ru) | 2012-09-10 |
AU2008214774A1 (en) | 2008-08-21 |
EP2121641B1 (en) | 2014-09-24 |
JP2010518137A (ja) | 2010-05-27 |
TWI372051B (en) | 2012-09-11 |
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