AR059513A1 - Derivados benzoil - piperidina como moduladores de 5ht/ d3 - Google Patents
Derivados benzoil - piperidina como moduladores de 5ht/ d3Info
- Publication number
- AR059513A1 AR059513A1 ARP070100651A ARP070100651A AR059513A1 AR 059513 A1 AR059513 A1 AR 059513A1 AR P070100651 A ARP070100651 A AR P070100651A AR P070100651 A ARP070100651 A AR P070100651A AR 059513 A1 AR059513 A1 AR 059513A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- halo
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente está relacionada con compuestos de benzoil piperidina como moduladores de receptores 5HT/D3. Compuestos utiles frente a los trastornos del SNC. Reivindicacion 1: Un compuesto de formula (1) en el que A es arilo o heteroarilo de 5 o 6 miembros opcionalmente sustituido con entre 1 y 5 sustituyentes seleccionados de entre el grupo que consiste en ciano, halo, alquilo C1-6, haloalquilo C1-6, alquilsulfonilo C1-6, o alcoxi C1-6; n es 1, 2, 3, o 4; p es 1, 2, 3, o 4; q es 0 o 1; r es 0, 1, 2, o 3; R1 es alquenilo C2-6 o alquinilo C2-6 sustituido con arilo, o es alquilo C1-6 opcionalmente sustituido con entre 1 y 5 sustituyentes seleccionados de entre el grupo que consiste en: halo, hidroxi, alquilo C1-6, haloalquilo C1-6, -CO(O)- alquilo C1-6, cicloalquilo C3-10, alcoxi C1-6 opcionalmente sustituido con uno, dos o tres halo o sustituido con arilo, arilo opcionalmente sustituido con halo o alcoxi C1-6, heteroarilo de 5 a 10 miembros opcionalmente sustituido con alquilo C1-6, y fenoxilo, o es alcoxi C1-6, o es cicloalquilo C3-10 opcionalmente sustituido por uno o más Ra; o es heterocicloalquilo de 4 a 10 miembros opcionalmente sustituido por uno o más Ra, o es arilo opcionalmente sustituido por uno o más Ra, o es heteroarilo de 5 a 10 miembros opcionalmente sustituido por uno o más Ra, o es -NRbRc, en el que Rb es H o alquilo C1-6 y en los que Rc es H, alquilo C1-6 o arilo opcionalmente sustituido por uno o más Ra, en los que Ra se selecciona de: halo, ciano, oxo, hidroxi, halobencenosulfonilo, alquilo C1-6 opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados de entre el grupo que consiste en: heterocicloalquilo de 5 a 10 miembros, y arilo que esta opcionalmente sustituido con halo o alcoxi C1-6, haloalquilo C1-6, 5 haloalcoxi C1-6, alcoxi C1-6 opcionalmente sustituido con arilo o heteroarilo de 5 a 10 miembros que está opcionalmente sustituido con alquilo C1-6, ariloxi, -NH(CO)-alquilo C1-6, -O(CO)-alquilo C1-6, alquilsulfonilo C1-6, arilo, heterocicloalquilo de 4 a 10 miembros opcionalmente sustituido con hidroxi, alquilo C1-6 u oxo, heteroarilo de 5 a 10 miembros opcionalmente sustituido con alquilo C1-6 u oxo, y dialquilamino C1-6; R2 es H, OH, alquilo C1-6 o halo; así como las sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06110112 | 2006-02-17 | ||
| EP06112464 | 2006-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059513A1 true AR059513A1 (es) | 2008-04-09 |
Family
ID=38091740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100651A AR059513A1 (es) | 2006-02-17 | 2007-02-15 | Derivados benzoil - piperidina como moduladores de 5ht/ d3 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8039490B2 (es) |
| EP (1) | EP1987019B1 (es) |
| JP (1) | JP4855485B2 (es) |
| KR (1) | KR101062513B1 (es) |
| AR (1) | AR059513A1 (es) |
| AU (1) | AU2007216563B2 (es) |
| BR (1) | BRPI0707960A2 (es) |
| CA (1) | CA2640807A1 (es) |
| CL (1) | CL2007000396A1 (es) |
| ES (1) | ES2399447T3 (es) |
| IL (1) | IL193176A (es) |
| NO (1) | NO20083584L (es) |
| RU (1) | RU2396265C2 (es) |
| TW (1) | TWI329107B (es) |
| WO (1) | WO2007093540A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2183245B1 (en) | 2007-07-26 | 2014-07-09 | F. Hoffmann-La Roche AG | Dual modulators of 5-ht2a and d3 receptors |
| MX2010001195A (es) * | 2007-08-09 | 2010-03-01 | Hoffmann La Roche | Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3. |
| BRPI0918949A2 (pt) | 2008-09-22 | 2019-09-24 | Hoffmann La Roche | moduladores de receptores de 5-ht2a e piperazina d3 |
| US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US9302989B2 (en) * | 2010-11-15 | 2016-04-05 | Abbvie Inc. | NAMPT and rock inhibitors |
| US8877778B2 (en) * | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
| US8722683B2 (en) | 2011-02-17 | 2014-05-13 | Hoffmann La-Roche Inc. | Benzodioxole piperazine compounds |
| US8598357B2 (en) | 2011-03-03 | 2013-12-03 | Hoffmann-La Roche Inc. | Benzodioxole piperidine compounds |
| US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
| AU2016258192B2 (en) | 2015-05-06 | 2021-07-29 | Leidos Biomedical Research, Inc. | K-Ras modulators |
| WO2018195439A2 (en) | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
| JP6948830B2 (ja) * | 2017-05-17 | 2021-10-13 | 花王株式会社 | 乳化化粧料 |
| JP7258009B2 (ja) | 2017-07-10 | 2023-04-14 | セルジーン コーポレイション | 抗増殖化合物及びその使用方法 |
| CA3157843A1 (en) | 2019-10-29 | 2021-05-06 | Shanghai Hansoh Biomedical Co., Ltd. | Modifier of four-membered ring derivative, preparation method and application thereof |
| EP4056568A4 (en) | 2019-11-05 | 2024-02-28 | Shanghai Hansoh Biomedical Co., Ltd. | BENZOTHIOPHENE DERIVATIVE REGULATOR, PREPARATION METHOD AND USE THEREOF |
| CN113277974B (zh) * | 2020-02-20 | 2023-04-07 | 上海科技大学 | 2-苯基环丙基甲基胺衍生物及其制备方法和用途 |
| EP4332093A1 (en) | 2021-04-28 | 2024-03-06 | Shanghai Hansoh Biomedical Co., Ltd. | Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024264A (en) | 1974-08-15 | 1977-05-17 | Ab Ferrosan | Diphenylbutylpiperidines |
| GB1514718A (en) | 1974-08-15 | 1978-06-21 | Ferrosan Ab | Diphenyl-butylpiperidines |
| JP2860689B2 (ja) * | 1990-03-14 | 1999-02-24 | 第一製薬株式会社 | ピリミジン誘導体 |
| US5229400A (en) * | 1990-10-05 | 1993-07-20 | Ajinomoto Co., Inc. | Piperidine compounds and their use as antiarrhythmic agents |
| PL350904A1 (en) | 1999-03-26 | 2003-02-10 | Astrazeneca Ab | Novel compounds |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| HUP0103986A2 (hu) * | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| EP1499607B1 (en) * | 2001-12-04 | 2005-12-07 | Actelion Pharmaceuticals Ltd. | 4-(piperidyl- and pyrrolidyl-alkyl-ureido)-quinolines as urotensin ii receptor antagonists |
| EP1348434A1 (en) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
| TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| US7186725B2 (en) * | 2003-01-03 | 2007-03-06 | Genzyme Corporation | Anti-inflammatory compositions and methods |
| EP2183245B1 (en) * | 2007-07-26 | 2014-07-09 | F. Hoffmann-La Roche AG | Dual modulators of 5-ht2a and d3 receptors |
| MX2010001195A (es) * | 2007-08-09 | 2010-03-01 | Hoffmann La Roche | Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3. |
-
2007
- 2007-02-07 RU RU2008133322/04A patent/RU2396265C2/ru not_active IP Right Cessation
- 2007-02-07 KR KR1020087022377A patent/KR101062513B1/ko not_active IP Right Cessation
- 2007-02-07 ES ES07704416T patent/ES2399447T3/es active Active
- 2007-02-07 EP EP07704416A patent/EP1987019B1/en not_active Not-in-force
- 2007-02-07 AU AU2007216563A patent/AU2007216563B2/en not_active Ceased
- 2007-02-07 BR BRPI0707960-5A patent/BRPI0707960A2/pt not_active IP Right Cessation
- 2007-02-07 CA CA002640807A patent/CA2640807A1/en not_active Abandoned
- 2007-02-07 JP JP2008554738A patent/JP4855485B2/ja not_active Expired - Fee Related
- 2007-02-07 WO PCT/EP2007/051160 patent/WO2007093540A1/en active Application Filing
- 2007-02-13 US US11/705,635 patent/US8039490B2/en not_active Expired - Fee Related
- 2007-02-13 TW TW096105346A patent/TWI329107B/zh active
- 2007-02-14 CL CL2007000396A patent/CL2007000396A1/es unknown
- 2007-02-15 AR ARP070100651A patent/AR059513A1/es unknown
-
2008
- 2008-07-31 IL IL193176A patent/IL193176A/en not_active IP Right Cessation
- 2008-08-19 NO NO20083584A patent/NO20083584L/no not_active Application Discontinuation
-
2011
- 2011-09-15 US US13/233,056 patent/US8415350B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120004208A1 (en) | 2012-01-05 |
| RU2008133322A (ru) | 2010-03-27 |
| JP4855485B2 (ja) | 2012-01-18 |
| AU2007216563A1 (en) | 2007-08-23 |
| EP1987019A1 (en) | 2008-11-05 |
| NO20083584L (no) | 2008-11-14 |
| CA2640807A1 (en) | 2007-08-23 |
| JP2009526807A (ja) | 2009-07-23 |
| EP1987019B1 (en) | 2012-11-28 |
| BRPI0707960A2 (pt) | 2011-05-10 |
| WO2007093540A1 (en) | 2007-08-23 |
| ES2399447T3 (es) | 2013-04-01 |
| TWI329107B (en) | 2010-08-21 |
| IL193176A (en) | 2013-01-31 |
| US20070197531A1 (en) | 2007-08-23 |
| CL2007000396A1 (es) | 2008-01-04 |
| RU2396265C2 (ru) | 2010-08-10 |
| US8039490B2 (en) | 2011-10-18 |
| TW200808758A (en) | 2008-02-16 |
| IL193176A0 (en) | 2009-02-11 |
| KR20080095899A (ko) | 2008-10-29 |
| KR101062513B1 (ko) | 2011-09-06 |
| US8415350B2 (en) | 2013-04-09 |
| AU2007216563B2 (en) | 2012-08-09 |
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Legal Events
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