AR074790A1 - Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. - Google Patents

Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.

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Publication number
AR074790A1
AR074790A1 ARP090104966A ARP090104966A AR074790A1 AR 074790 A1 AR074790 A1 AR 074790A1 AR P090104966 A ARP090104966 A AR P090104966A AR P090104966 A ARP090104966 A AR P090104966A AR 074790 A1 AR074790 A1 AR 074790A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
cyano
independently
haloalkyl
Prior art date
Application number
ARP090104966A
Other languages
English (en)
Inventor
Steve Nanchen
Noele Gauvry
Thomas Goebel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR074790A1 publication Critical patent/AR074790A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Los compuestos de fórmula (1) son útiles en el control de parásitos, en particular ectoparásitos, en y sobre animales de sangre caliente. Reivindicación 1: Un compuesto de fórmula (1) que incluye todos los geométricos y estereoisómeros, N-óxidos, y sales de los mismos, en donde X es S(O)m, O ó NR5' y X1 y X2 son cada uno independientemente del otro CR3' o N; n es un entero de 0 a 4; m es un entero de 0 a 2; B1, B2 y B3 se seleccionan cada uno independientemente del grupo que consiste de CR2' y N; cada R2' es independientemente del otro H o R2; cada R3' es independientemente del otro H o R3; R1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, cada uno no sustituido o sustituido con uno o más sustituyentes independientemente seleccionados de R4; R4 es halógeno, alquilo C1-6, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano o nitro; cada R2 es independientemente halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, N-mono o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano (-CN) o nitro (-NO2); cada R3 es independientemente H, halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, amino, N-mono- o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano o nitro o no sustituido o halógeno-, alquilo C1-6-, haloalquilo C1-6-, alcoxi C1-6-, haloalcoxi C1-6-, amino-, ciano- o fenilo sustituido con nitro, piridilo o pirimidilo; Z es halógeno, un radical Q o un grupo -C(W)-NR5R6; Q es un anillo heterocíclico de 5 ó 6 miembros o un sistema de anillo carbocíclico C6-10 o un sistema de anillo hetero-bicíclico fusionado de a 8, 9 ó 10-miembros, cada uno de los cuales es no sustituido o sustituido con uno o más sustituyentes independientemente seleccionados de halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-di-alquilamino C1-4, alcoxicarbonilo C1-6, sulfonamido, N-mono- o N,N,di-alquilsulfonamino C1-4, alquilcarbonilamino C1-6, N-mono- o N,N-di-alquilaminocarbonilo C1-6, alcanoilo C2-6, un grupo -(alqu)-C(W')NR5''R7, fenilo, bencilo, benzoilo, fenoxi, piridilo, piridil-(alqu)-, pirimidilo y pirimidil-(alqu)-, en donde el fenilo, bencilo, benzoilo, fenoxi, piridilo y pirimidilo son cada uno no sustituido o sustituido por halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, ciano, nitro o amino; (alqu) es alquileno C1-6 de cadena recta o ramificada; W y W' son cada uno independientemente del otro O ó S; R5, R5' y R5'' son cada uno independientemente del otro H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7, cicloalquilalquilo C4-7, alquilcarbonilo C1-6 o alcoxicarbonilo C1-6; R6 es H; Q', en donde Q' tiene independientemente el mismo significado de Q; o es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7, o cicloalquilalquilo C4-7, cada uno no sustituido o sustituido por halógeno alcoxi C1-6, alquiltio C1-6. alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-dialquilamino C1-6, cicloalquilamino C3-6, alcoxicarbonilo C1-6, alcanoilo C2-6, alquilcarbonilamino C1-6, aminocarbonilo, N-mono- o N,N-di-alquilaminocarbonilo C1-6, un grupo -C(W')NR5''R7 o un radical Q'', en donde Q'' independientemente tiene el mismo significado de Q; o R5 y R6 junto con el átomo de N al cual ellos se adhieren, forman un anillo de 3 a 7 miembros que opcionalmente contiene un heteroátomo adicional seleccionado del grupo que consiste de N, S y O y cuyo anillo es adicionalmente no sustituido o sustituido por alquilo C1-2, alquilo C1-2, alcoxi C1-2, halógeno, ciano o nitro; y R7 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, que es cada uno no sustituido o sustituido por halógeno alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano, nitro, amino, N-mono- o N,N-di-alquilamino C1-6, piridilo, pirimidilo o tiazolilo, o por piridilo, pirimidilo o tiazolilo que es mono- o disustituido por halógeno, ciano, alquilo C1-2 o haloalquilo C1-2.
ARP090104966A 2008-12-19 2009-12-17 Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. AR074790A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08172398 2008-12-19
CH11842009 2009-07-27

Publications (1)

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AR074790A1 true AR074790A1 (es) 2011-02-09

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ARP090104966A AR074790A1 (es) 2008-12-19 2009-12-17 Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.

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US (3) US8383659B2 (es)
EP (1) EP2379537B9 (es)
JP (1) JP5608676B2 (es)
CN (1) CN102256971B (es)
AR (1) AR074790A1 (es)
AU (1) AU2009327079B2 (es)
BR (1) BRPI0923009B1 (es)
CA (1) CA2747354C (es)
CL (1) CL2011001390A1 (es)
CO (1) CO6341475A2 (es)
DK (1) DK2379537T5 (es)
ES (1) ES2395704T3 (es)
HU (2) HUE015568T4 (es)
LU (1) LUC00030I2 (es)
MX (1) MX2011006568A (es)
NL (1) NL300891I2 (es)
NO (1) NO2017048I1 (es)
NZ (1) NZ593135A (es)
PL (1) PL2379537T3 (es)
PT (1) PT2379537E (es)
RU (1) RU2518462C2 (es)
TW (1) TWI454472B (es)
WO (1) WO2010070068A2 (es)
ZA (1) ZA201103780B (es)

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