AR081998A1 - Compuestos de isoxazolinas, composicion para el control de parasitos en base al compuesto, metodo de control de parasitos y uso del compuesto para tal fin - Google Patents

Compuestos de isoxazolinas, composicion para el control de parasitos en base al compuesto, metodo de control de parasitos y uso del compuesto para tal fin

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Publication number
AR081998A1
AR081998A1 ARP110102102A ARP110102102A AR081998A1 AR 081998 A1 AR081998 A1 AR 081998A1 AR P110102102 A ARP110102102 A AR P110102102A AR P110102102 A ARP110102102 A AR P110102102A AR 081998 A1 AR081998 A1 AR 081998A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
cyano
alkoxy
halogen
Prior art date
Application number
ARP110102102A
Other languages
English (en)
Inventor
Thomas Goebel
Steve Nanchen
Nolle Gauvry
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR081998A1 publication Critical patent/AR081998A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Los compuestos de la presente son útiles en el control de parásitos, en particular ectoparásitos, en y de vertebrados.Reivindicación 1: Un compuesto de fórmula (1) incluyendo todos los isómeros geométricos y estereoisómeros, N-óxidos, S-óxidos y sales de este, en donde X es S(O)m, O ó NR5’ y X1 y X2 son cada uno independientemente del otro CR3’ o N; n es un número entero de 0 a 4; m es un número entero de 0 a 2; R5’ es H, alquilo C1-6, haloalquilo C1-6, alquilcarbonilo C1-6 o alcoxicarbonilo C1-6; B1, B2 y B3 cada uno independientemente se selecciona del grupo que consiste de CR2’ y N; cada R2’ es independientemente del otro H o R2; cada R3’ es independientemente del otro H o R3; R1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, cada uno sustituido o no sustituido con uno o más sustituyentes independientemente seleccionados de R4; R4 es un halógeno, alquilo C1-6, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano o nitro; cada R2 es independientemente un halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, N-mono- o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano (-CN) o nitro (-NO2); cada R3 es independientemente H, halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilo C1-6-sulfinilo, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, amino, N-mono- o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano, nitro o no sustituido o halógeno-, alquilo C1-6-, haloalquilo C1-6-, alcoxi C1-6, haloalcoxi C1-6-, amino-, ciano- o nitro- fenilo sustituido, piridilo o pirimidilo; R5 es H, alquilo C1-6, haloalquilo C1-6, halógeno o ciano; o R5 y X2 juntos con los átomos de C intermedios forman un anillo carbocíclico de 5- ó 6-miembros; R6 es H; alquilo C1-6, el cual es sustituido o no sustituido por un alcoxi C1-4, ciano, fenilo, etenilo o etinilo; alquilcarbonilo C2-7; haloalquilcarbonilo C2-7 alcoxicarbonilo C2-7; Z es un alquilo C1-6, un grupo -C(O)-Q, un grupo -C(S)-Q o un grupo -S(O)t-Q; t es 1 ó 2; Q es alcoxi C1-6; haloalcoxi C1-6; alquiltio C1-6 haloalquiltio C1-6; NR7R8; CO2R7; COR7; alquilo C1-6 el cual es sustituido o no sustituido por un cicloalquilo C3-6, halógeno, ciano, nitro, hidroxi, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, alquilcarbonilamino C1-6, haloalquilcarboniloamino C1-6, alcoxicarbonilo C1-6, sulfonamido, N-mono- o N,N-di-alquilsulfonamido C1-4, N-mono- o N,N-di-alquilaminocarbonilo C1-6, N-mono- o N,N-di-haloalquilaminocarbonilo C1-6, alcanoil C2-6, no sustituido o alquilo C1-2-, haloalquilo C1-2-, alcoxi C1-2-, haloalcoxi C1-2-, halógeno-, ciano- o C1-4-alcoxicarbonilo-arilo C6-10 sustituido, o no sustituido o alquilo C1-2-, haloalquilo C1-2-, alcoxi C1-2, haloalcoxi C1-2-, halógeno-, ciano- o alcoxicarbonilo C1-4-heterociclil sustituido de 4- a 6- miembros; alquenilo C2-6; alquinilo C2-6; cicloalquilo C3-6 el cual es sustituido o no sustituido por un halógeno, alquilo C1-2 o haloalquilo C1-2; arilo C6-10 sustituido o no sustituido por un alquilo C1-2, haloalquilo C1-2, alcoxi C1-2, haloalcoxi C1-2, halógeno, ciano o alcoxicarbonilo C1-4; o heterociclil de 4- a 6-miembros sustituido o no sustituido por un alquilo C1-2, haloalquilo C1-2, alcoxi C1-2, haloalcoxi C1-2, halógeno, ciano o alcoxicarbonilo C1-4; y R7 y R8 son cada uno independientemente del otro H, alquilo C1-6, haloalquilo C1-6 o cicloalquilo C3-6.
ARP110102102A 2010-06-17 2011-06-16 Compuestos de isoxazolinas, composicion para el control de parasitos en base al compuesto, metodo de control de parasitos y uso del compuesto para tal fin AR081998A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH9852010 2010-06-17

Publications (1)

Publication Number Publication Date
AR081998A1 true AR081998A1 (es) 2012-11-07

Family

ID=44533456

Family Applications (1)

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ARP110102102A AR081998A1 (es) 2010-06-17 2011-06-16 Compuestos de isoxazolinas, composicion para el control de parasitos en base al compuesto, metodo de control de parasitos y uso del compuesto para tal fin

Country Status (10)

Country Link
US (1) US8592418B2 (es)
EP (1) EP2582696B1 (es)
JP (1) JP2013530176A (es)
CN (1) CN102947296B (es)
AR (1) AR081998A1 (es)
AU (1) AU2011267113B2 (es)
CA (1) CA2800967A1 (es)
UY (1) UY33403A (es)
WO (1) WO2011157748A1 (es)
ZA (1) ZA201209024B (es)

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EP2582696B1 (en) 2014-10-22
EP2582696A1 (en) 2013-04-24
CN102947296B (zh) 2015-08-26
US20130096124A1 (en) 2013-04-18
CA2800967A1 (en) 2011-12-22
US8592418B2 (en) 2013-11-26
CN102947296A (zh) 2013-02-27
AU2011267113A1 (en) 2012-12-13
UY33403A (es) 2011-12-30
JP2013530176A (ja) 2013-07-25
WO2011157748A1 (en) 2011-12-22
AU2011267113B2 (en) 2014-05-22
ZA201209024B (en) 2013-07-31

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