AR085903A1 - Compuestos de pirazol sustituidos con halogeno - Google Patents

Compuestos de pirazol sustituidos con halogeno

Info

Publication number
AR085903A1
AR085903A1 ARP120100818A AR085903A1 AR 085903 A1 AR085903 A1 AR 085903A1 AR P120100818 A ARP120100818 A AR P120100818A AR 085903 A1 AR085903 A1 AR 085903A1
Authority
AR
Argentina
Prior art keywords
haloalkyl
optionally substituted
alkyl
nitrogen
cycloalkyl
Prior art date
Application number
Other languages
English (en)
Inventor
Maue Michael Dr
Adelt Isabelle Dr
Heil Markus Dr
Dr Jeschke Peter Prof
Kapferer Tobias Dr
Mhlthau Friedrich August Dr
Sudau Alexander Dr
Malsam Olga Dr
Lsel Peter Dr
Voerste Arnd Dr
Ulrich Grgens
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of AR085903A1 publication Critical patent/AR085903A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

El uso de los compuestos para combatir parásitos animales. Se refiere además a procedimientos y productos intermedios para la preparación de los compuestos según la fórmula (1).Reivindicación 1: Compuestos de la fórmula general (1), en los que R1 representa hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, alquilcarbonilo C1-6, alcoxicarbonilo C1-6, cianoalquilo C1-2, arilalquilo C1-3, heteroarilalquilo C1-3 eventualmente sustituidos; el grupo químico A1 representa CR2 o nitrógeno, A2 representa CR3 o nitrógeno, A3 representa CR4 o nitrógeno, y A4 representa CR5 o nitrógeno, pero donde no más de tres de los grupos químicos A1 a A4 representan simultáneamente nitrógeno; R2, R3, R4 y R5 representan independientemente entre sí hidrógeno, halógeno, CN, NO2, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, alquilamino C1-6, N,N-di-alquilamino C1-6, N-alquilaminocarbonilo C1-6, N-cicloalquilaminocarbonilo C3-6 o (alcoxi C1-3)-carbonilo eventualmente sustituidos; en caso que ninguno de los grupos A2 y A3 represente nitrógeno, R3 y R4 junto con el átomo de carbono al que están unidos pueden formar un anillo de 5 ó 6 miembros que contiene 0, 1 ó 2 átomos de nitrógeno y/o 0 ó 1 átomo de oxígeno y/o 0 ó 1 átomo de azufre, o en caso que ninguno de los grupos A1 y A2 represente nitrógeno, R2 y R3 junto con el átomo de carbono al que están unidos pueden formar un anillo de 6 miembros que contiene 0, 1 ó 2 átomos de nitrógeno; W representa oxígeno o azufre; R6 representa hidrógeno, alquilo C1-6, arilalquilo C1-3, heteroarilalquilo C1-3, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, (alquil C1-3)-cicloalquilo C3-6 y (cicloalquil C3-6)-alquilo C1-3 eventualmente sustituidos, alquilcarbonilo C1-6, alcoxicarbonilo C1-6; Q representa el resto de fórmula (2); E representa un enlace, -CH2-, S, SO, SO2, -S-CH2-, -SO-CH2-, -SO2-CH2-, -CH2-S-CH2-, -CH2-SO-CH2-, -CH2-SO2-CH2-, -S-CH2-CH2-, -SO-CH2-CH2-, -SO2-CH2-CH2-, -NR6-CH2-, -CH2-NR6-CH2-; R7 representa ciano y C(=S)NH2; Z1 representa un haloalquilo C1-6 y cicloalquilo C3-6 eventualmente sustituidos, halocicloalquilo C3-6; y Z2 representa halógeno, ciano, nitro o un haloalquilo C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6 eventualmente sustituidos; y Z3 representa hidrógeno o un alquilo C1-6, alquenilo C1-4, alquinilo C1-4, haloalquilo C1-6 eventualmente sustituidos. Reivindicación 12: Compuestos de las fórmulas generales (3) y (4), en las que R2, R3, R4 y R5 representan independientemente entre sí hidrógeno, halógeno, ciano, nitro, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, alquilamino C1-6, N,N-di-alquilamino C1-6, N-alquilaminocarbonilo C1-6, N-cicloalquilaminocarbonilo C3-6 o (alcoxi C1-3)-carbonilo eventualmente sustituidos. Reivindicación 13: Compuestos de las fórmulas generales (5) y (6), en las que X1 representa halógeno, ciano y haloalquilo C1-4, y Z2 representa halógeno, ciano, nitro o un haloalquilo C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6 eventualmente sustituido, y Z3 representa hidrógeno o un alquilo C1-6, alquenilo C1-4, alquinilo C1-4, haloalquilo C1-6 eventualmente sustituido, e Y representa un alquilo C1-6 eventualmente sustituido.
ARP120100818 2011-03-18 2012-03-13 Compuestos de pirazol sustituidos con halogeno AR085903A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161454134P 2011-03-18 2011-03-18
EP11158838 2011-03-18
EP11190693 2011-11-25

Publications (1)

Publication Number Publication Date
AR085903A1 true AR085903A1 (es) 2013-11-06

Family

ID=46878641

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100818 AR085903A1 (es) 2011-03-18 2012-03-13 Compuestos de pirazol sustituidos con halogeno

Country Status (17)

Country Link
US (1) US9126945B2 (es)
EP (1) EP2686303B1 (es)
JP (1) JP5951650B2 (es)
KR (1) KR101834362B1 (es)
CN (1) CN103502221B (es)
AR (1) AR085903A1 (es)
AU (1) AU2012230503B2 (es)
BR (1) BR112013023924A2 (es)
CA (1) CA2830117C (es)
CO (1) CO6852084A2 (es)
DK (1) DK2686303T3 (es)
ES (1) ES2564972T3 (es)
IL (1) IL228307A (es)
MX (1) MX350121B (es)
RU (1) RU2600739C2 (es)
WO (1) WO2012126766A1 (es)
ZA (1) ZA201307753B (es)

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CO6852084A2 (es) 2014-01-30
EP2686303A1 (de) 2014-01-22
ZA201307753B (en) 2015-04-29
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US9126945B2 (en) 2015-09-08
EP2686303B1 (de) 2016-01-20
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MX350121B (es) 2017-08-28
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DK2686303T3 (en) 2016-03-29
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US20140088153A1 (en) 2014-03-27
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