AR085657A1 - Compuestos de isoxazol - Google Patents
Compuestos de isoxazolInfo
- Publication number
- AR085657A1 AR085657A1 ARP120100793A ARP120100793A AR085657A1 AR 085657 A1 AR085657 A1 AR 085657A1 AR P120100793 A ARP120100793 A AR P120100793A AR P120100793 A ARP120100793 A AR P120100793A AR 085657 A1 AR085657 A1 AR 085657A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- cyano
- alkoxy
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Los compuestos de la fórmula (1) son útiles en el control de parásitos, en particular ectoparásitos, en y sobre todo vertebrados.Reivindicación 1: Un compuesto de la fórmula (1) que incluye todos los estereoisómeros y geométricos, óxidos N, óxidos S y sales de los mismos, en donde: X es S(O)m, O ó NR5’ y X1 y X2 son cada uno independiente del otro CR3 o N; m es un entero de 0 a 2; R5’ es H, alquilo C1-6, haloalquilo C1-6, alquilcarbonilo C1-6 o alcoxicarbonilo C1-6; cada R3 es independientemente H, halógeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, halocicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, amino, N-mono o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano, nitro o no sustituido o halógeno-, alquilo C1-6-, haloalquilo C1-6-, alcoxi C1-6-, haloalcoxi C1-6-, amino-, ciano- o fenilo sustituido por nitro, piridilo o pirimidilo; B y B’ son cada uno independientemente un grupo CR2’; B1, B2 y B3 cada uno se seleccionan independientemente del grupo que consiste CR2’ y N; cada R2’ es independientemente del otro H o R2; cada R2 es independientemente halógeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, N-mono o N,N-di-alquilamino C1-6, alcoxicarbonilo C1-6, ciano (-CN) o nitro (-NO2); R1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilcicloalquilo C4-7 o cicloalquilalquilo C4-7, cada uno sustituido o no sustituido con uno o más sustituyentes seleccionados independientemente de R4; R4 es halógeno, hidroxi, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, ciano o nitro; R5 es H, alquilo C1-6, haloalquilo C1-6, halógeno o ciano; o R5 y X2 junto con los átomos C intermedios forman un anillo carbocíclico de 5 ó 6 miembros; o R5 y X1 junto con los átomos C intermedios forman un anillo carbocíclico de 5 ó 6 miembros; R6 es H; alquilo C1-6, que es sustituido o no sustituido por alcoxi C1-4, ciano, fenilo, etenilo o etinilo; alquilcarbonilo C2-7; haloalquilcarbonilo C2-7; o alcoxicarbonilo C2-7; Z es alquilo C1-6, un grupo -C(O)-Q, un grupo -C(S)-Q o un grupo -S(O)t-Q; t es 1 ó 2; Q es alcoxi C1-6; haloalcoxi C1-6; alquiltio C1-6; haloalquiltio C1-6; NR7R8; C(O)OR7; C(O)R7; alquilo C1-6 que es sustituido o no sustituido por cicloalquilo C3-6, halógeno, ciano, nitro, hidroxi, alcoxi C1-6, haloalcoxi C1-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, NHC(O)R7, alcoxicarbonilo C1-6, sulfonamido, N-mono- o N,N-di-alquilsufonamido C1-4, C(O)NR7R8, alcanoilo C2-6, no sustituido o alquilo C1-2-, haloalquilo C1-2-, alcoxi C1-2-, haloalcoxi C1-2-, halógeno-, ciano- o alcoxicarbonilo C1-4-arilo C6-10 sustituido, o no sustituido o alquilo C1-2-, haloalquilo C1-2-, alcoxi C1-2-, haloalcoxi C1-2-, halógeno-, ciano- o alcoxicarbonilo C1-4-heterociclilo de 4 a 6 miembros sustituido; alquenilo C2-6; alquinilo C2-6; cicloalquilo C3-6 que es sustituido o no sustituido por halógeno, alquilo C1-2 o haloalquilo C1-2; arilo C6-10 no sustituido o sustituido por alquilo C1-2, haloalquilo C1-2, alcoxi C1-2, haloalcoxi C1-2, halógeno, ciano o alcoxicarbonilo C1-4; o heterociclilo de 4 a 6 miembros sustituido o no sustituido por alquilo C1-2, haloalquilo C1-2, alcoxi C1-2, haloalcoxi C1-2, halógeno, ciano o alcoxicarbonilo C1-4; y R7 y R8 son cada uno independiente del otro H, alquilo C1-6, haloalquilo C1-6, no sustituido o alquilo C1-4 sustituido cicloalquilo C3-6, alquenilo C2-6 o alquinilo C2-6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH4072011 | 2011-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR085657A1 true AR085657A1 (es) | 2013-10-16 |
Family
ID=45809012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120100793A AR085657A1 (es) | 2011-03-10 | 2012-03-09 | Compuestos de isoxazol |
Country Status (15)
Country | Link |
---|---|
US (1) | US8822466B2 (es) |
EP (1) | EP2683713B1 (es) |
JP (1) | JP2014507459A (es) |
CN (1) | CN103502246A (es) |
AR (1) | AR085657A1 (es) |
AU (1) | AU2012224521B2 (es) |
BR (1) | BR112013022755A2 (es) |
CA (1) | CA2829149A1 (es) |
CL (1) | CL2013002472A1 (es) |
CO (1) | CO6801794A2 (es) |
ES (1) | ES2542409T3 (es) |
MX (1) | MX2013010297A (es) |
RU (1) | RU2013145304A (es) |
WO (1) | WO2012120135A1 (es) |
ZA (1) | ZA201306175B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
ME03323B (me) | 2012-02-06 | 2019-10-20 | Merial Inc | Paraziticidne oralne veterinarske kompozicije koje sadrže sistemski djelujuća aktivna sredstva, metodi i primjene istih |
JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
LT2953942T (lt) | 2013-02-06 | 2018-02-12 | Bayer Cropscience Aktiengesellschaft | Halogenpakeistieji pirazolo dariniai kaip pesticidai |
CN105473584B (zh) | 2013-06-24 | 2020-01-31 | 勃林格殷格翰动物保健美国公司 | 噻吩-或呋喃-取代的异噻唑啉化合物 |
WO2015039073A1 (en) | 2013-09-16 | 2015-03-19 | Kellogg Glen E | Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methds of use thereof |
NZ719916A (en) | 2013-11-01 | 2017-09-29 | Merial Inc | Antiparasitic and pesticidal isoxazoline compounds |
CN106061965A (zh) | 2014-01-03 | 2016-10-26 | 拜耳动物保健有限责任公司 | 作为农药的新型吡唑基杂芳基酰胺 |
US10857121B2 (en) | 2014-04-17 | 2020-12-08 | Merial Inc. | Use of malononitrile compounds for protecting animals from parasites |
WO2016008830A1 (de) | 2014-07-15 | 2016-01-21 | Bayer Cropscience Aktiengesellschaft | Aryl-triazolyl-pyridine als schädlingsbekämpfungsmittel |
EP3207023B1 (en) | 2014-10-14 | 2019-09-18 | Syngenta Participations AG | Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof |
KR102443434B1 (ko) * | 2014-10-14 | 2022-09-14 | 신젠타 파티서페이션즈 아게 | 1-(3,5-디클로로-4-플루오로-페닐)-2,2,2-트리플루오로-에타논의 제조 방법 |
US9975823B2 (en) | 2014-10-14 | 2018-05-22 | Syngenta Participations Ag | Process for the preparation of 5-bromo-1,2,3-trichlorobenzene |
EP3207024B1 (en) | 2014-10-14 | 2018-07-25 | Syngenta Participations AG | Process for the preparation of halo-substituted trifluoroacetophenones |
EP3018129A1 (en) * | 2014-11-10 | 2016-05-11 | Novartis Tiergesundheit AG | Diaryl isoxazoline compound |
UY36570A (es) * | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
JP6824900B2 (ja) * | 2015-04-08 | 2021-02-03 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | イソオキサゾリン活性薬剤を含む延長放出注射製剤、方法及びその使用 |
SI3298027T1 (sl) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintične depsipeptidne spojine |
UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
EP3525590A1 (en) | 2016-10-14 | 2019-08-21 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
CN110167921A (zh) | 2016-11-16 | 2019-08-23 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫缩肽化合物 |
WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
CN111194316A (zh) | 2017-08-14 | 2020-05-22 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的吡唑-异噁唑啉化合物 |
CN112996788B (zh) | 2018-07-09 | 2024-07-16 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫的杂环化合物 |
WO2020112374A1 (en) | 2018-11-20 | 2020-06-04 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
EP3941587A1 (en) | 2019-03-19 | 2022-01-26 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
AR119790A1 (es) | 2019-08-29 | 2022-01-12 | Pi Industries Ltd | Compuestos de isoxazolina y su uso como agentes para el control de plagas |
US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
AU2021278871A1 (en) | 2020-05-28 | 2023-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
WO2021242581A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
CA3205997A1 (en) | 2020-12-21 | 2022-06-30 | University Of Georgia Research Foundation Inc. | Parasiticidal collar comprising isoxazoline compounds |
CA3209562A1 (en) | 2021-01-27 | 2022-08-04 | Intervet International B.V. | Cyclopropylamide compounds against parasites in fish |
US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
CN101331127B (zh) * | 2005-12-16 | 2012-05-23 | 杜邦公司 | 用于防治无脊椎害虫的5-芳基异噁唑啉 |
TWI412322B (zh) * | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
ES2344027T3 (es) * | 2006-03-10 | 2010-08-16 | Nissan Chemical Industries, Ltd. | Compuesto de isoxazolina sustituido y agente de control de plagas. |
BRPI0810196A2 (pt) * | 2007-04-10 | 2011-12-06 | Bayer Cropscience Ag | inseticidas de derivados de aril isoxazolina |
TWI461411B (zh) | 2007-08-17 | 2014-11-21 | Du Pont | 製備5-鹵烷基-4,5-二氫異唑衍生物之方法 |
WO2009071500A2 (en) | 2007-12-03 | 2009-06-11 | Novartis Ag | Organic compounds |
NZ593135A (en) * | 2008-12-19 | 2013-04-26 | Novartis Ag | Isoxazoline derivatives and their use as pesticide |
JP2010235590A (ja) * | 2009-03-09 | 2010-10-21 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
-
2012
- 2012-03-09 MX MX2013010297A patent/MX2013010297A/es not_active Application Discontinuation
- 2012-03-09 JP JP2013557121A patent/JP2014507459A/ja active Pending
- 2012-03-09 CA CA2829149A patent/CA2829149A1/en not_active Abandoned
- 2012-03-09 AR ARP120100793A patent/AR085657A1/es unknown
- 2012-03-09 ES ES12707629.7T patent/ES2542409T3/es active Active
- 2012-03-09 AU AU2012224521A patent/AU2012224521B2/en not_active Expired - Fee Related
- 2012-03-09 EP EP20120707629 patent/EP2683713B1/en not_active Not-in-force
- 2012-03-09 CN CN201280012748.2A patent/CN103502246A/zh active Pending
- 2012-03-09 WO PCT/EP2012/054161 patent/WO2012120135A1/en active Application Filing
- 2012-03-09 RU RU2013145304/04A patent/RU2013145304A/ru not_active Application Discontinuation
- 2012-03-09 US US14/004,307 patent/US8822466B2/en not_active Expired - Fee Related
- 2012-03-09 BR BR112013022755A patent/BR112013022755A2/pt not_active IP Right Cessation
-
2013
- 2013-08-16 ZA ZA2013/06175A patent/ZA201306175B/en unknown
- 2013-08-21 CO CO13198103A patent/CO6801794A2/es active IP Right Grant
- 2013-08-27 CL CL2013002472A patent/CL2013002472A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2013002472A1 (es) | 2014-03-07 |
CA2829149A1 (en) | 2012-09-13 |
WO2012120135A1 (en) | 2012-09-13 |
CO6801794A2 (es) | 2013-11-29 |
US20130345221A1 (en) | 2013-12-26 |
BR112013022755A2 (pt) | 2019-09-24 |
ZA201306175B (en) | 2014-04-30 |
CN103502246A (zh) | 2014-01-08 |
EP2683713B1 (en) | 2015-04-22 |
AU2012224521B2 (en) | 2015-10-29 |
US8822466B2 (en) | 2014-09-02 |
JP2014507459A (ja) | 2014-03-27 |
EP2683713A1 (en) | 2014-01-15 |
RU2013145304A (ru) | 2015-04-20 |
MX2013010297A (es) | 2013-10-17 |
AU2012224521A1 (en) | 2013-09-05 |
ES2542409T3 (es) | 2015-08-05 |
NZ614662A (en) | 2015-06-26 |
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