NO20083584L - Bensoyl-piperidin derivater som 5HT2/D3 modulatorer - Google Patents
Bensoyl-piperidin derivater som 5HT2/D3 modulatorerInfo
- Publication number
- NO20083584L NO20083584L NO20083584A NO20083584A NO20083584L NO 20083584 L NO20083584 L NO 20083584L NO 20083584 A NO20083584 A NO 20083584A NO 20083584 A NO20083584 A NO 20083584A NO 20083584 L NO20083584 L NO 20083584L
- Authority
- NO
- Norway
- Prior art keywords
- modulators
- benzoyl
- piperidine derivatives
- ht2a
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser med den generelle formel som doble modulatorer av 5-HT2a- og D3-reseptorer som er anvendelige mot CNS-lidelser, hvor A, R1, R2, n, p, q og r er som definert i beskrivelsen. 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06110112 | 2006-02-17 | ||
EP06112464 | 2006-04-11 | ||
PCT/EP2007/051160 WO2007093540A1 (en) | 2006-02-17 | 2007-02-07 | Benzoyl-piperidine derivatives as 5ht2/d3 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083584L true NO20083584L (no) | 2008-11-14 |
Family
ID=38091740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083584A NO20083584L (no) | 2006-02-17 | 2008-08-19 | Bensoyl-piperidin derivater som 5HT2/D3 modulatorer |
Country Status (15)
Country | Link |
---|---|
US (2) | US8039490B2 (no) |
EP (1) | EP1987019B1 (no) |
JP (1) | JP4855485B2 (no) |
KR (1) | KR101062513B1 (no) |
AR (1) | AR059513A1 (no) |
AU (1) | AU2007216563B2 (no) |
BR (1) | BRPI0707960A2 (no) |
CA (1) | CA2640807A1 (no) |
CL (1) | CL2007000396A1 (no) |
ES (1) | ES2399447T3 (no) |
IL (1) | IL193176A (no) |
NO (1) | NO20083584L (no) |
RU (1) | RU2396265C2 (no) |
TW (1) | TWI329107B (no) |
WO (1) | WO2007093540A1 (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5502733B2 (ja) * | 2007-07-26 | 2014-05-28 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht2a及びd3受容体の二重のモジュレーター |
JP5296073B2 (ja) * | 2007-08-09 | 2013-09-25 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht2a及びd3受容体のデュアルモジュレーターとしてのベンゾイル−ピペリジン誘導体 |
KR101329548B1 (ko) | 2008-09-22 | 2013-11-18 | 에프. 호프만-라 로슈 아게 | 피페라진 d3 및 5-ht2a 수용체 조절제 |
US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
RU2013126657A (ru) * | 2010-11-15 | 2014-12-27 | Эббви Инк. | Ингибиторы nampt и rock |
US8877778B2 (en) * | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8722683B2 (en) | 2011-02-17 | 2014-05-13 | Hoffmann La-Roche Inc. | Benzodioxole piperazine compounds |
US8598357B2 (en) | 2011-03-03 | 2013-12-03 | Hoffmann-La Roche Inc. | Benzodioxole piperidine compounds |
US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
CN107847495A (zh) * | 2015-05-06 | 2018-03-27 | 加利福尼亚大学董事会 | K‑Ras调节剂 |
US11358940B2 (en) | 2017-04-20 | 2022-06-14 | The Regents Of The University Of California | K-Ras modulators |
JP6948830B2 (ja) * | 2017-05-17 | 2021-10-13 | 花王株式会社 | 乳化化粧料 |
KR102656934B1 (ko) | 2017-07-10 | 2024-04-16 | 셀진 코포레이션 | 항증식성 화합물 및 이의 사용 방법 |
BR112022007238A2 (pt) | 2019-10-29 | 2022-07-05 | Shanghai Hansoh Biomedical Co Ltd | Compostos modificadores derivados de anel de quatro membros, métodos para preparar os referidos compostos, composição e uso |
TW202118758A (zh) | 2019-11-05 | 2021-05-16 | 大陸商上海翰森生物醫藥科技有限公司 | 苯并噻吩類衍生物調節劑、其製備方法和應用 |
WO2021164661A1 (zh) * | 2020-02-20 | 2021-08-26 | 上海科技大学 | 2-苯基环丙基甲基胺衍生物及其制备方法和用途 |
KR20240005786A (ko) | 2021-04-28 | 2024-01-12 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 피페라진 폴리사이클릭 유도체를 함유하는 염, 이의 결정형, 이의 제조 방법, 및 이의 용도 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024264A (en) * | 1974-08-15 | 1977-05-17 | Ab Ferrosan | Diphenylbutylpiperidines |
GB1514718A (en) | 1974-08-15 | 1978-06-21 | Ferrosan Ab | Diphenyl-butylpiperidines |
JP2860689B2 (ja) * | 1990-03-14 | 1999-02-24 | 第一製薬株式会社 | ピリミジン誘導体 |
EP0479601B1 (en) * | 1990-10-05 | 1999-12-15 | Ajinomoto Co., Inc. | Piperidine derivatives and their use as antiarrhythmic agents |
CZ20013451A3 (cs) | 1999-03-26 | 2002-04-17 | Astrazeneca Ab | Nové sloučeniny |
GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
HUP0103986A2 (hu) * | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
CA2473892C (en) * | 2001-12-04 | 2010-09-21 | Actelion Pharmaceuticals Ltd | Novel quinoline derivatives |
EP1348434A1 (en) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
AU2003303678A1 (en) | 2003-01-03 | 2004-08-10 | Genzyme Corporation | Urea derivatives and their use as anti-inflammatory agents |
JP5502733B2 (ja) * | 2007-07-26 | 2014-05-28 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht2a及びd3受容体の二重のモジュレーター |
JP5296073B2 (ja) * | 2007-08-09 | 2013-09-25 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht2a及びd3受容体のデュアルモジュレーターとしてのベンゾイル−ピペリジン誘導体 |
-
2007
- 2007-02-07 WO PCT/EP2007/051160 patent/WO2007093540A1/en active Application Filing
- 2007-02-07 KR KR1020087022377A patent/KR101062513B1/ko not_active IP Right Cessation
- 2007-02-07 JP JP2008554738A patent/JP4855485B2/ja not_active Expired - Fee Related
- 2007-02-07 ES ES07704416T patent/ES2399447T3/es active Active
- 2007-02-07 EP EP07704416A patent/EP1987019B1/en not_active Not-in-force
- 2007-02-07 RU RU2008133322/04A patent/RU2396265C2/ru not_active IP Right Cessation
- 2007-02-07 AU AU2007216563A patent/AU2007216563B2/en not_active Ceased
- 2007-02-07 BR BRPI0707960-5A patent/BRPI0707960A2/pt not_active IP Right Cessation
- 2007-02-07 CA CA002640807A patent/CA2640807A1/en not_active Abandoned
- 2007-02-13 US US11/705,635 patent/US8039490B2/en not_active Expired - Fee Related
- 2007-02-13 TW TW096105346A patent/TWI329107B/zh active
- 2007-02-14 CL CL2007000396A patent/CL2007000396A1/es unknown
- 2007-02-15 AR ARP070100651A patent/AR059513A1/es unknown
-
2008
- 2008-07-31 IL IL193176A patent/IL193176A/en not_active IP Right Cessation
- 2008-08-19 NO NO20083584A patent/NO20083584L/no not_active Application Discontinuation
-
2011
- 2011-09-15 US US13/233,056 patent/US8415350B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2007216563A1 (en) | 2007-08-23 |
EP1987019A1 (en) | 2008-11-05 |
US20120004208A1 (en) | 2012-01-05 |
IL193176A (en) | 2013-01-31 |
JP2009526807A (ja) | 2009-07-23 |
RU2396265C2 (ru) | 2010-08-10 |
TWI329107B (en) | 2010-08-21 |
WO2007093540A1 (en) | 2007-08-23 |
IL193176A0 (en) | 2009-02-11 |
RU2008133322A (ru) | 2010-03-27 |
EP1987019B1 (en) | 2012-11-28 |
US20070197531A1 (en) | 2007-08-23 |
US8039490B2 (en) | 2011-10-18 |
KR101062513B1 (ko) | 2011-09-06 |
ES2399447T3 (es) | 2013-04-01 |
JP4855485B2 (ja) | 2012-01-18 |
CA2640807A1 (en) | 2007-08-23 |
KR20080095899A (ko) | 2008-10-29 |
TW200808758A (en) | 2008-02-16 |
US8415350B2 (en) | 2013-04-09 |
AR059513A1 (es) | 2008-04-09 |
AU2007216563B2 (en) | 2012-08-09 |
CL2007000396A1 (es) | 2008-01-04 |
BRPI0707960A2 (pt) | 2011-05-10 |
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