AR062731A1 - Derivados de quinazolinona e isoquinolinona, composiciones farmaceuticas que los contienen, y su uso para tratar o prevenir trastornos relacionados con el estres o la depresion. - Google Patents
Derivados de quinazolinona e isoquinolinona, composiciones farmaceuticas que los contienen, y su uso para tratar o prevenir trastornos relacionados con el estres o la depresion.Info
- Publication number
- AR062731A1 AR062731A1 ARP070103999A ARP070103999A AR062731A1 AR 062731 A1 AR062731 A1 AR 062731A1 AR P070103999 A ARP070103999 A AR P070103999A AR P070103999 A ARP070103999 A AR P070103999A AR 062731 A1 AR062731 A1 AR 062731A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- heterocyclic ring
- cycloalkyl
- halogen
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a un derivado de quinazolinona o isoquinolinona de formula (1) donde R1 es alquilo C1-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-3, alquenilo C2-6, alquinilo C2-6, estando dichos alquilo C1-6, cicloalquilo C3-6 y cicloalquil C3-6-alquilo C1-3 opcionalmente sustituidos con hidroxi, alquiloxi C1-6, ciano o uno o más halogenos; R2 es arilo C1-6 opcionalmente sustituido con uno a tres sustituyentes seleccionados entre halogeno, hidroxi, ciano, alquilo C1-6, cicloalquilo C3-6, alquiloxi C1-6, cicloalquiloxi C3-6, estando dichos alquilo C1-6, cicloalquilo C3-6, alquiloxi C1-6 y cicloalquiloxi C3-6, opcionalmente sustituidos con uno o más halogenos; o R2 es un sistema de anillo heteroarilo de 5-10 miembros que comprende un heteroátomo seleccionado entre N, O y S, y está opcionalmente sustituido con un sustituyente seleccionado entre metilo, alquiloxi C1-6 y halogeno; o R2 es cicloalquilo C4-7; R3 es un sustituyente opcional seleccionado entre. alquilo C1-6, alquiloxi C1-6 y halogeno, estando dicho alquilo C1-6 y alquiloxi C1-6 opcionalmente sustituidos con uno o más halogenos; R4 es un grupo ubicado en la posicion 6 o 7 del anillo quinazolinona o isoquinolinona y tiene la formula 2, donde R5 junto con uno de R6 forman un anillo heterocíclico saturado o no saturado de 4-8 miembros que opcionalmente comprende una especie heteroatomica adicional seleccionada entre O, S y NR9, estando dicho anillo heterocíclico opcionalmente sustituido con uno o dos sustituyentes seleccionados entre metilo, halogeno, hidroxi y oxo, o R5 junto con uno de R7 y R8 forman un anillo heterocíclico de 6-8 miembro opcionalmente sustituido con uno o dos sustituyentes seleccionados entre metilo, halogeno, hidroxi y oxo; cada R6 es independientemente H, halogeno o alquilo C1-4 opcionalmente sustituido con halogeno o SO2CH3, o uno de R6 junto con R5 forman un anillo heterocíclico saturado o no saturado de 4-8 miembros que opcionalmente comprende una especie heteroatomica adicional seleccionada entre O, S y NR9, estando dicho anillo heterocíclico opcionalmente sustituido con tino o dos sustituyentes seleccionados entre metilo, halogeno, hidroxi y oxo; R7 y R8 son independientemente H, alquilo C1-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-3, cianoC1-3alquilo, arilo C6-10, aril C6-10-alquilo C1-3, alquiloxi C1-3-alquilo C1-3 o acilo C1-6, estando dichos alquilo C1-6, cicloalquilo C3-6 y cicloalquil C3-6-alquilo C1-3 opcionalmente sustituidos con hidroxi, uno o más halogenos o dialquilamino C1-2; o R7 y R8, junto con el nitrogeno al cual están unidos, forman un anillo heterocíclico saturado o no saturado de 4-8 miembros que opcionalmente comprende una especie heteroatomica adicional seleccionada entre O, S y NR10, estando dicho anillo heterocíclico opcionalmente sustituido con uno o dos sustituyentes seleccionados entre alquilo C1-6, halogeno, hidroxi, alquiloxi C1-6, ciano y COOR11; o uno de R7 y R8 es Y, CH2Y o CH2CH2Y, donde Y es un anillo heterocíclico saturado de 4-6 miembros que comprende una especie heterocíclica seleccionada entre O, SO2 y NR10, estando dicho anillo opcionalmente sustituido con 1-2 sustituyentes seleccionados entre metilo o halogeno; o uno de R7 o R8 junto con R5 forman un anillo heterocíclico de 6-8 miembros que está opcionalmente sustituido con uno o dos sustituyentes seleccionados entre metilo, halogeno, hidroxi y oxo; o uno de R7 y R8 junto con R12 forman un anillo heterocíclico saturado o no saturado de 4-8 miembros que opcionalmente comprende una especie heteroatomica adicional seleccionada entre O, S y NR13, estando dicho anillo heterocíclico opcionalmente sustituido con uno o dos sustituyentes seleccionados entre metilo, hidroxi y oxo; R9 y R10 son independientemente H, alquilo C1-6 o acilo C1-6; R11 es H o alquilo C1-6; cada R12 es independientemente H o alquilo C1-4, o uno de R12 junto con uno de R7 o R8 forman un anillo heterocíclico saturado o no saturado de 4-8 miembros que opcionalmente comprende una especie heteroatomica adicional seleccionada entre O, S y NR13, estando dicho anillo heterocíclico opcionalmente sustituido con uno o dos sustituyentes seleccionados entre metilo, hidroxi y oxo; R13 es H, alquilo C1-6 o acilo C1-6; m es 2-3; y X es N o CH; o una sal o solvato farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84371806P | 2006-09-11 | 2006-09-11 |
Publications (1)
Publication Number | Publication Date |
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AR062731A1 true AR062731A1 (es) | 2008-11-26 |
Family
ID=39184483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103999A AR062731A1 (es) | 2006-09-11 | 2007-09-11 | Derivados de quinazolinona e isoquinolinona, composiciones farmaceuticas que los contienen, y su uso para tratar o prevenir trastornos relacionados con el estres o la depresion. |
Country Status (20)
Country | Link |
---|---|
US (1) | US7820649B2 (es) |
EP (1) | EP2069315B1 (es) |
JP (1) | JP5256202B2 (es) |
KR (1) | KR20090107994A (es) |
CN (1) | CN101600698B (es) |
AR (1) | AR062731A1 (es) |
AT (1) | ATE523500T1 (es) |
AU (1) | AU2007296634B2 (es) |
CA (1) | CA2663161C (es) |
CL (1) | CL2007002635A1 (es) |
CO (1) | CO6160322A2 (es) |
EC (1) | ECSP099177A (es) |
IL (1) | IL197530A0 (es) |
MX (1) | MX2009002686A (es) |
NO (1) | NO20091012L (es) |
NZ (1) | NZ575426A (es) |
PE (1) | PE20080841A1 (es) |
RU (1) | RU2009113612A (es) |
TW (1) | TW200827352A (es) |
WO (1) | WO2008033764A2 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010229035A (ja) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−4−オン誘導体 |
WO2009130231A1 (en) * | 2008-04-24 | 2009-10-29 | Glaxo Group Limited | Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists |
JP5369721B2 (ja) * | 2009-01-30 | 2013-12-18 | 大正製薬株式会社 | ピリドピリミジン−4−オン誘導体 |
RU2012119488A (ru) | 2009-10-13 | 2013-11-20 | Мсд Осс Б.В. | Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором |
RS54112B1 (en) | 2010-10-01 | 2015-12-31 | Taisho Pharmaceutical Co. Ltd | DERIVAT 1,2,4-TRIAZOLONA |
SI2772482T1 (sl) | 2011-10-27 | 2016-06-30 | Taisho Pharmaceutical Co., Ltd. | Derivat azola |
US20150045551A1 (en) * | 2012-03-30 | 2015-02-12 | Taisho Pharmaceutical Co., Ltd | Fused azole derivative |
AU2013276617B9 (en) | 2012-06-13 | 2018-03-29 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
MY187449A (en) | 2013-11-26 | 2021-09-22 | Hoffmann La Roche | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
DK3122750T3 (da) | 2014-03-26 | 2019-11-04 | Hoffmann La Roche | Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere |
PE20161223A1 (es) | 2014-03-26 | 2016-11-12 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa) |
WO2016020405A1 (en) * | 2014-08-04 | 2016-02-11 | Sandoz Ag | Novel routes of synthesis for the preparation of suvorexant |
US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | フェノキシメチル誘導体 |
JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
BR112018006024A2 (pt) | 2015-09-24 | 2020-05-12 | F. Hoffmann-La Roche Ag | Compostos bicíclicos como inibidores de atx |
CN107614505B (zh) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | 作为双重atx/ca抑制剂的新型二环化合物 |
MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
DK3386591T3 (da) | 2015-12-09 | 2020-09-28 | Cadent Therapeutics Inc | Heteroaromatic nmda receptor modulators and uses thereof |
AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
DK3830092T3 (en) | 2018-08-03 | 2023-08-07 | Novartis Ag | Heteroaromatic nmda receptor modulators and uses thereof |
CN111100063B (zh) * | 2018-10-25 | 2022-05-17 | 南京药石科技股份有限公司 | 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2506767A1 (fr) * | 1981-05-26 | 1982-12-03 | Synthelabo | Derives heterocycliques d'amidoximes, leur preparation et leur application en therapeutique |
DE69838025T2 (de) | 1997-04-25 | 2008-05-08 | Janssen Pharmaceutica N.V. | Chinazolinone die farnesyltransferase hemmen |
IL139199A (en) | 1999-11-02 | 2006-10-31 | Nihon Nohyaku Co Ltd | Derivatives of aminoquinazolinone (thion) or their salts, their intermediates, pesticides and method of use |
FR2804114B1 (fr) * | 2000-01-25 | 2002-03-08 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
FR2842527B1 (fr) * | 2002-07-19 | 2005-01-28 | Sanofi Synthelabo | Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique |
BRPI0506909A (pt) * | 2004-01-16 | 2007-05-29 | Hoffmann La Roche | derivados de 1-benzil-5piperazin-1-il-3,4 diidro-1h-quinazolin-2-ona e os respectivos derivados de 1h-benzo (1,2,6) tiadiazina-2,2-dióxido e 1,4-diidro-benzo (d) (1,3)oxazin-2-ona como moduladores do receptor de 5-hidroxitriptamina (5-ht) para o tratamento de doenças do sistema nervoso central |
AU2005247808B2 (en) * | 2004-05-31 | 2011-02-10 | Msd K.K. | Quinazoline derivative |
WO2006012577A2 (en) * | 2004-07-22 | 2006-02-02 | Bayer Pharmaceuticals Corporation | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake |
TW200643015A (en) | 2005-03-11 | 2006-12-16 | Akzo Nobel Nv | 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives |
EP2066640B1 (en) * | 2006-09-11 | 2011-09-07 | N.V. Organon | 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives |
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2007
- 2007-09-10 KR KR1020097007035A patent/KR20090107994A/ko not_active Application Discontinuation
- 2007-09-10 AU AU2007296634A patent/AU2007296634B2/en active Active
- 2007-09-10 JP JP2009527608A patent/JP5256202B2/ja active Active
- 2007-09-10 MX MX2009002686A patent/MX2009002686A/es not_active Application Discontinuation
- 2007-09-10 US US11/852,762 patent/US7820649B2/en active Active
- 2007-09-10 AT AT07842157T patent/ATE523500T1/de not_active IP Right Cessation
- 2007-09-10 CA CA2663161A patent/CA2663161C/en active Active
- 2007-09-10 NZ NZ575426A patent/NZ575426A/en not_active IP Right Cessation
- 2007-09-10 CN CN2007800416250A patent/CN101600698B/zh active Active
- 2007-09-10 EP EP07842157A patent/EP2069315B1/en active Active
- 2007-09-10 RU RU2009113612/04A patent/RU2009113612A/ru unknown
- 2007-09-10 WO PCT/US2007/078022 patent/WO2008033764A2/en active Application Filing
- 2007-09-11 CL CL2007002635A patent/CL2007002635A1/es unknown
- 2007-09-11 TW TW096133906A patent/TW200827352A/zh unknown
- 2007-09-11 PE PE2007001221A patent/PE20080841A1/es not_active Application Discontinuation
- 2007-09-11 AR ARP070103999A patent/AR062731A1/es not_active Application Discontinuation
-
2009
- 2009-03-06 NO NO20091012A patent/NO20091012L/no not_active Application Discontinuation
- 2009-03-11 IL IL197530A patent/IL197530A0/en unknown
- 2009-03-11 EC EC2009009177A patent/ECSP099177A/es unknown
- 2009-04-08 CO CO09036257A patent/CO6160322A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2009002686A (es) | 2009-10-13 |
IL197530A0 (en) | 2009-12-24 |
EP2069315A4 (en) | 2010-11-03 |
JP5256202B2 (ja) | 2013-08-07 |
ECSP099177A (es) | 2009-06-30 |
NZ575426A (en) | 2010-09-30 |
RU2009113612A (ru) | 2010-10-20 |
US20080090802A1 (en) | 2008-04-17 |
KR20090107994A (ko) | 2009-10-14 |
NO20091012L (no) | 2009-03-26 |
EP2069315B1 (en) | 2011-09-07 |
EP2069315A2 (en) | 2009-06-17 |
ATE523500T1 (de) | 2011-09-15 |
PE20080841A1 (es) | 2008-06-14 |
CA2663161A1 (en) | 2008-03-20 |
TW200827352A (en) | 2008-07-01 |
WO2008033764A3 (en) | 2008-12-18 |
CO6160322A2 (es) | 2010-05-20 |
CN101600698B (zh) | 2012-01-11 |
AU2007296634B2 (en) | 2012-09-20 |
CL2007002635A1 (es) | 2009-10-23 |
CN101600698A (zh) | 2009-12-09 |
AU2007296634A1 (en) | 2008-03-20 |
US7820649B2 (en) | 2010-10-26 |
CA2663161C (en) | 2014-10-28 |
WO2008033764A2 (en) | 2008-03-20 |
JP2010502746A (ja) | 2010-01-28 |
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