CO6251260A2 - Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c. - Google Patents

Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c.

Info

Publication number
CO6251260A2
CO6251260A2 CO10097369A CO10097369A CO6251260A2 CO 6251260 A2 CO6251260 A2 CO 6251260A2 CO 10097369 A CO10097369 A CO 10097369A CO 10097369 A CO10097369 A CO 10097369A CO 6251260 A2 CO6251260 A2 CO 6251260A2
Authority
CO
Colombia
Prior art keywords
nrarb
alkyl
independently selected
alkoxyalkyl
haloalkyl
Prior art date
Application number
CO10097369A
Other languages
English (en)
Inventor
Carol Bachand
Makonen Belema
Daniel H Deon
Andrew C Good
Jason Goodrich
Clint A James
Rico Lavoie
Omar D Lopez
Alain Martel
Nicholas A Meanwell
Van N Nguyen
Jeffrey Lee Romine
Edward H Ruediger
Lawrence B Snyder
Laurent Denis R St
Fukang Yang
David R Langley
Gan Wang
Lawrence G Hamann
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6251260A2 publication Critical patent/CO6251260A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

La presente descripción se refiere a compuestos, composiciones y métodos para la terapia de infección del unas de hepatitis C (VHC). También se describen composiciones farmacéuticas que contienen tales compuestos y métodos para utilizar estos compuestos en la terapia de infección por VHC. 1.- Un compuesto de fórmula (I)o una de sus sales farmacéuticamente aceptables, caracterizado porque u y u' son independientemente 0, 1, 2 ó 3; cada uno de D y E es un anillo aromático de cinco miembros que contiene uno, dos o tres heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; cada R1 y R1' se selecciona independientemente de alcoxi, alcoxialquilo, alcoxicarbonilo, alquilo, arilalcoxicarbonilo, carboxi, formilo, halo, haloalquilo, hidroxi, hidroxialquilo, NRaRb, (NRaRb)alquilo y (NRaRb)carbonilo; R2 y R2', junto con los átomos de carbono a los que están unidos, forman un anillo de cinco a ocho miembros que opcionalmente contiene uno o dos heteroátomos seleccionados independientemente de nitrógeno, oxigeno y azufre; en donde el anillo de cinco a ocho miembros está opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente de alcoxi, alcoxialquilo, alcoxicarbonilo, alquilo, alquilsulfonilo, arilo, arilalquilo, arilsulfonilo, carboxi, formilo, halo, haloalcoxi, haloalquilo, hidroxi, hidroxialquilo, NRaRb, (NRaRb)alquilo, (NRaRb)carbonilo, oxo y espirociclo; cada uno de R3 y R3' se selecciona independientemente de hidrógeno, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, arilalcoxicarbonilo, carboxi, haloalquilo, heterociclilalquilo, hidroxialquilo, (NRaRb)carbonilo y trialquilsililalcoxialquilo; R4 y R4' se seleccionan cada uno independientemente de en donde; cada m es independientemente 0, 1 ó 2; ...
CO10097369A 2008-02-13 2010-08-09 Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c. CO6251260A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2826608P 2008-02-13 2008-02-13

Publications (1)

Publication Number Publication Date
CO6251260A2 true CO6251260A2 (es) 2011-02-21

Family

ID=40409903

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10097369A CO6251260A2 (es) 2008-02-13 2010-08-09 Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c.

Country Status (27)

Country Link
US (1) US7704992B2 (es)
EP (1) EP2242750B1 (es)
JP (1) JP5425815B2 (es)
KR (1) KR101614964B1 (es)
CN (1) CN101998954B (es)
AR (1) AR070365A1 (es)
AU (1) AU2009215105B2 (es)
BR (1) BRPI0908456A2 (es)
CA (1) CA2715550C (es)
CL (1) CL2009000323A1 (es)
CO (1) CO6251260A2 (es)
CY (1) CY1114298T1 (es)
DK (1) DK2242750T3 (es)
EA (1) EA020511B1 (es)
ES (1) ES2415208T3 (es)
HK (1) HK1144195A1 (es)
HR (1) HRP20130421T1 (es)
IL (1) IL207258A0 (es)
MX (1) MX2010008531A (es)
NZ (1) NZ586990A (es)
PE (1) PE20091575A1 (es)
PL (1) PL2242750T3 (es)
PT (1) PT2242750E (es)
SI (1) SI2242750T1 (es)
TW (1) TWI423798B (es)
WO (1) WO2009102568A1 (es)
ZA (1) ZA201005485B (es)

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