AR076002A1 - Derivados imidazolicos heterociclicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden. - Google Patents
Derivados imidazolicos heterociclicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden.Info
- Publication number
- AR076002A1 AR076002A1 ARP100101038A ARP100101038A AR076002A1 AR 076002 A1 AR076002 A1 AR 076002A1 AR P100101038 A ARP100101038 A AR P100101038A AR P100101038 A ARP100101038 A AR P100101038A AR 076002 A1 AR076002 A1 AR 076002A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- independently selected
- nrarb
- cycloalkyl
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 22
- 229910052739 hydrogen Inorganic materials 0.000 abstract 17
- 239000001257 hydrogen Substances 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 11
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 10
- 150000002431 hydrogen Chemical group 0.000 abstract 10
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 9
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- -1 carboxy, formyl Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Substances 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005469 ethylenyl group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) o una sal farmacéuticamente aceptable del mismo, en la que L se selecciona a partir de -O-, -CH2CH2-, -CH=CH-, -C:::C-, -OCH2-, -CH2O-, -CH2OCH2-, y grupo e formulas (2); X es hidrogeno (H) o halogeno y Z es hidrogeno; o X y Z, junto con los átomos de carbono a los que están unidos, forman un anillo condensado aromático o no aromático de cinco a ocho miembros que opcionalmente contiene uno o dos heteroátomos que se seleccionan independientemente a partir de nitrogeno, oxígeno, y azufre; en la que el anillo de cinco a ocho miembros está opcionalmente sustituido con uno, dos, o tres sustituyentes que se seleccionan independientemente a partir de alcoxi, alcoxialquilo, alcoxicarbonilo, alquilo, alquilsulfonilo, arilo, arilalquilo, arilsulfonilo, carboxi, formilo, halo, haloalcoxi, haloalquilo, hidroxi, hidroxialquilo, -NRaRb, (NRaRb)alquilo, (NRaRb)carbonilo, oxo, y espirociclo; X' es hidrogeno (H) o halogeno y Z' es hidrogeno; o X' y Z', junto con los átomos de carbono a los que están unidos, forman un anillo condensado aromático o no aromático de cinco a ocho miembros que opcionalmente contiene uno o dos heteroátomos que se seleccionan independientemente a partir de nitrogeno, oxígeno, y azufre; en los que el anillo de cinco a ocho miembros está opcionalmente sustituido con uno, dos, o tres sustituyentes que se seleccionan independientemente a partir de alcoxi, alcoxialquilo, alcoxicarbonilo, alquilo, alquilsulfonilo, arilo, arilalquilo, arilsulfonilo, carboxi, formilo, halo, haloalcoxi, haloalquilo, hidroxi, hidroxialquilo, -NRaRb, (NRaRb)alquilo, (NRaRb)carbonilo, oxo, y espirociclo; Y y Y' son cada uno independientemente -CH2-, -CH2CH2-, o -CH2O-, en los que el -CH2O- se dibuja de tal forma que el átomo de oxigeno esté unido al átomo de carbono sustituido con Rv y Rq o Rv' y Rq'; Rp es hidrogeno o alquilo C1-4; Rq es hidrogeno, alquilo, o halo; o Rp y Rq, junto con los átomos de carbono a los que están unidos, forman un anillo cicloalquilo; Rv se selecciona a partir de hidrogeno, alquilo, halo, e hidroxi; o Rv y Rq, junto con el átomo de carbono al que están unidos, forman un grupo etilenilo o un anillo cicloalquilo; Rp' es hidrogeno o alquilo C1-4; Rq' es hidrogeno, alquilo, o halo; o Rp' y Rq' junto con los átomos de carbono a los que están unidos, forman un anillo cicloalquilo; Rv' se seleccionan independientemente a partir de hidrogeno, alquilo, halo, e hidroxi; o Rv' y Rq', junto con el átomo de carbono al que están unidos, forman un grupo etilenilo o un anillo cicloalquilo; Rw y Rw' se seleccionan independientemente a partir de hidrogeno y alquilo; R1 es hidrogeno o -CO)Rx; R2 es hidrogeno o -C(O)Ry; Rx y Ry se seleccionan independientemente a partir de cicloalquilo, heteroarilo, heterociclilo, alcoxi, y alquilo, estando dicho alquilo sustituido por uno o más sustituyentes que se seleccionan independientemente a partir de arilo, alquenilo, cicloalquilo, heterociclilo, heteroarilo, -OR3, -C(O)OR4, NRaRb, y C(O)NRcRd, en los que cualquiera de dichos arilo y heteroarilo puede estar opcionalmente sustituido con uno o más sustituyentes que se seleccionan independientemente a partir de alquenilo, alquilo, haloalquilo, arilalquilo, heterociclilo, heterociclilalquilo, halogeno, ciano, nitro, -C(O)OR4, -OR5, NRaRb, (NRaRb)alquilo, y (MeO)(HO)P(O)O-, y en los que cualquiera de dichos cicloalquilo y heterociclilo puede opcionalmente estar condensado a un anillo aromático y puede estar opcionalmente sustituido con uno o más sustituyentes que se seleccionan independientemente a partir de alquilo, hidroxilo, halogeno, arilo, NRaRb, oxo, y -C(O)OR4; R3 es hidrogeno, alquilo, o arilalquilo; R4 es alquilo o arilalquilo; R5 es hidrogeno, alquilo, o arilalquilo; Ra y Rb se seleccionan independientemente a partir de hidrogeno, alquilo, cicloalquilo, arilalquilo, heteroarilo, -C(O)R6, -C(O)OR7, -C(O)NRcRd, y (NRcRd)alquilo, o de forma alternativa, Ra y Rb, junto con el átomo de nitrogeno al que están unidos, forman un anillo de cinco o seis miembros o estructura anular bicíclica con puente, en la que dicho anillo de cinco o seis miembros o estructura anular bicíclica con puente opcionalmente pueden contener uno o dos heteroátomos adicionales que se seleccionan independientemente a partir de nitrogeno, oxígeno, y azufre y pueden contener uno, dos, o tres sustituyentes que se seleccionan independientemente a partir de alquilo C1-6, haloalquilo C1-4, arilo, hidroxilo, alcoxi C1-6, haloalcoxi C1-4, y halogeno; R6 es alquilo; R7 es alquilo, arilalquilo, cicloalquilo, o haloalquilo; y Rc y Rd se seleccionan independientemente a partir de hidrogeno, alquilo, arilalquilo y cicloalquilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16453109P | 2009-03-30 | 2009-03-30 | |
| US12/729,940 US8796466B2 (en) | 2009-03-30 | 2010-03-23 | Hepatitis C virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076002A1 true AR076002A1 (es) | 2011-05-11 |
Family
ID=42320079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101038A AR076002A1 (es) | 2009-03-30 | 2010-03-30 | Derivados imidazolicos heterociclicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8796466B2 (es) |
| EP (1) | EP2414350B1 (es) |
| JP (1) | JP5612660B2 (es) |
| KR (1) | KR20120034603A (es) |
| CN (1) | CN102448956B (es) |
| AR (1) | AR076002A1 (es) |
| AU (1) | AU2010234970A1 (es) |
| BR (1) | BRPI1013393A2 (es) |
| CA (1) | CA2757269A1 (es) |
| CL (1) | CL2011002426A1 (es) |
| CO (1) | CO6430431A2 (es) |
| EA (1) | EA022384B1 (es) |
| IL (1) | IL215055A0 (es) |
| MX (1) | MX2011009948A (es) |
| NZ (1) | NZ595168A (es) |
| PE (1) | PE20120546A1 (es) |
| SG (1) | SG174521A1 (es) |
| WO (1) | WO2010117635A1 (es) |
| ZA (1) | ZA201106795B (es) |
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| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
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| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
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| NZ595168A (en) | 2013-05-31 |
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| JP5612660B2 (ja) | 2014-10-22 |
| CN102448956B (zh) | 2015-05-06 |
| CL2011002426A1 (es) | 2012-03-02 |
| WO2010117635A1 (en) | 2010-10-14 |
| EA201171152A1 (ru) | 2012-10-30 |
| MX2011009948A (es) | 2011-10-06 |
| JP2012522053A (ja) | 2012-09-20 |
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