EA201171152A1 - Ингибиторы вируса гепатита c - Google Patents
Ингибиторы вируса гепатита cInfo
- Publication number
- EA201171152A1 EA201171152A1 EA201171152A EA201171152A EA201171152A1 EA 201171152 A1 EA201171152 A1 EA 201171152A1 EA 201171152 A EA201171152 A EA 201171152A EA 201171152 A EA201171152 A EA 201171152A EA 201171152 A1 EA201171152 A1 EA 201171152A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hepatitis
- new compounds
- virus inhibitors
- compositions containing
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
В заявке описаны новые соединения формулы (I) и композиции, содержащие такие новые соединения. Эти соединения являются эффективными противовирусными средствами, в особенности, в качестве ингибиторов функции белка NS5A, кодированного вирусом гепатита С (ВГС). Соответственно также описан способ лечения связанных с ВГС заболеваний или состояний путем применения этих новых соединений или композиций, содержащих такие новые соединения.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16453109P | 2009-03-30 | 2009-03-30 | |
US12/729,940 US8796466B2 (en) | 2009-03-30 | 2010-03-23 | Hepatitis C virus inhibitors |
PCT/US2010/028456 WO2010117635A1 (en) | 2009-03-30 | 2010-03-24 | Hepatitis c virus inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201171152A1 true EA201171152A1 (ru) | 2012-10-30 |
EA022384B1 EA022384B1 (ru) | 2015-12-30 |
Family
ID=42320079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171152A EA022384B1 (ru) | 2009-03-30 | 2010-03-24 | Ингибиторы вируса гепатита c |
Country Status (19)
Country | Link |
---|---|
US (1) | US8796466B2 (ru) |
EP (1) | EP2414350B1 (ru) |
JP (1) | JP5612660B2 (ru) |
KR (1) | KR20120034603A (ru) |
CN (1) | CN102448956B (ru) |
AR (1) | AR076002A1 (ru) |
AU (1) | AU2010234970A1 (ru) |
BR (1) | BRPI1013393A2 (ru) |
CA (1) | CA2757269A1 (ru) |
CL (1) | CL2011002426A1 (ru) |
CO (1) | CO6430431A2 (ru) |
EA (1) | EA022384B1 (ru) |
IL (1) | IL215055A0 (ru) |
MX (1) | MX2011009948A (ru) |
NZ (1) | NZ595168A (ru) |
PE (1) | PE20120546A1 (ru) |
SG (1) | SG174521A1 (ru) |
WO (1) | WO2010117635A1 (ru) |
ZA (1) | ZA201106795B (ru) |
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AR076002A1 (es) | 2011-05-11 |
MX2011009948A (es) | 2011-10-06 |
CO6430431A2 (es) | 2012-04-30 |
AU2010234970A1 (en) | 2011-10-06 |
EP2414350A1 (en) | 2012-02-08 |
CL2011002426A1 (es) | 2012-03-02 |
KR20120034603A (ko) | 2012-04-12 |
CA2757269A1 (en) | 2010-10-14 |
ZA201106795B (en) | 2013-02-27 |
EA022384B1 (ru) | 2015-12-30 |
NZ595168A (en) | 2013-05-31 |
JP2012522053A (ja) | 2012-09-20 |
US20110077280A1 (en) | 2011-03-31 |
BRPI1013393A2 (pt) | 2016-03-29 |
US8796466B2 (en) | 2014-08-05 |
SG174521A1 (en) | 2011-10-28 |
IL215055A0 (en) | 2011-11-30 |
PE20120546A1 (es) | 2012-05-21 |
EP2414350B1 (en) | 2014-11-12 |
CN102448956A (zh) | 2012-05-09 |
CN102448956B (zh) | 2015-05-06 |
JP5612660B2 (ja) | 2014-10-22 |
WO2010117635A1 (en) | 2010-10-14 |
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