EA200900676A1 - Ингибиторы вируса гепатита с - Google Patents

Ингибиторы вируса гепатита с

Info

Publication number
EA200900676A1
EA200900676A1 EA200900676A EA200900676A EA200900676A1 EA 200900676 A1 EA200900676 A1 EA 200900676A1 EA 200900676 A EA200900676 A EA 200900676A EA 200900676 A EA200900676 A EA 200900676A EA 200900676 A1 EA200900676 A1 EA 200900676A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatitis
virus inhibitors
disclosed
virus
inhibitors
Prior art date
Application number
EA200900676A
Other languages
English (en)
Inventor
Най Син
Брайан Ли Венэйблс
Ли-Цян Сунь
Сын-Юуэнь Сит
Янь Чэнь
Пол Майкл Скола
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA200900676A1 publication Critical patent/EA200900676A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Раскрыты ингибиторы вируса гепатита С, имеющие общую формулу (I). Также раскрыты композиции, содержащие соединения, и способы использования соединений для ингибирования HCV.
EA200900676A 2006-11-09 2007-11-08 Ингибиторы вируса гепатита с EA200900676A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86503406P 2006-11-09 2006-11-09
US11/934,840 US7772180B2 (en) 2006-11-09 2007-11-05 Hepatitis C virus inhibitors
PCT/US2007/084012 WO2008060927A2 (en) 2006-11-09 2007-11-08 Hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
EA200900676A1 true EA200900676A1 (ru) 2010-02-26

Family

ID=39304590

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900676A EA200900676A1 (ru) 2006-11-09 2007-11-08 Ингибиторы вируса гепатита с

Country Status (18)

Country Link
US (1) US7772180B2 (ru)
EP (1) EP2086963B1 (ru)
JP (1) JP2010509359A (ru)
KR (1) KR20090082467A (ru)
CN (1) CN101541784B (ru)
AR (1) AR063653A1 (ru)
AU (1) AU2007319435A1 (ru)
BR (1) BRPI0718625A2 (ru)
CA (1) CA2669310A1 (ru)
CL (1) CL2007003250A1 (ru)
EA (1) EA200900676A1 (ru)
IL (1) IL198248A0 (ru)
MX (1) MX2009004888A (ru)
NO (1) NO20091591L (ru)
NZ (1) NZ576817A (ru)
PE (1) PE20081344A1 (ru)
TW (1) TW200826938A (ru)
WO (1) WO2008060927A2 (ru)

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AR063653A1 (es) 2009-02-04
WO2008060927A3 (en) 2008-07-03
CL2007003250A1 (es) 2008-05-23
BRPI0718625A2 (pt) 2014-04-01
US20080119461A1 (en) 2008-05-22
CN101541784A (zh) 2009-09-23
CA2669310A1 (en) 2008-05-22
JP2010509359A (ja) 2010-03-25
EP2086963A2 (en) 2009-08-12
AU2007319435A1 (en) 2008-05-22
NO20091591L (no) 2009-07-28
EP2086963B1 (en) 2015-09-16
PE20081344A1 (es) 2008-09-18
IL198248A0 (en) 2009-12-24
WO2008060927A2 (en) 2008-05-22
TW200826938A (en) 2008-07-01
CN101541784B (zh) 2013-04-24
MX2009004888A (es) 2009-05-19
KR20090082467A (ko) 2009-07-30
NZ576817A (en) 2011-08-26

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