PE20081344A1 - Inhibidores del virus de la hepatitis c - Google Patents
Inhibidores del virus de la hepatitis cInfo
- Publication number
- PE20081344A1 PE20081344A1 PE2007001545A PE2007001545A PE20081344A1 PE 20081344 A1 PE20081344 A1 PE 20081344A1 PE 2007001545 A PE2007001545 A PE 2007001545A PE 2007001545 A PE2007001545 A PE 2007001545A PE 20081344 A1 PE20081344 A1 PE 20081344A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cyclopropylsulfonil
- carbamoil
- prolinamide
- isoquinolinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Abstract
REFERIDA A UN DERIVADO DE ISOQUINOLINA DE FORMULA (I), DONDE m ES 1, 2 O 3; R1 ES OH O NHSO2R6; R6 ES ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R2 ES H, ALQUENILO, ALQUILO, CICLOALQUILO, ENTRE OTROS; R3 ES ALQUENILO, ALCOXIALQUILO, ALQUILO, ENTRE OTROS; R4 ES FENILO O UN ANILLO PARCIALMENTE O COMPLETAMENTE INSATURADO DE CINCO O SEIS MIEMBROS QUE CONTIENE OPCIONALMENTE DE UNO A CUATRO HETEROATOMOS SELECCIONADOS DE N, O Y S, DONDE CADA ANILLO PUEDE ESTAR SUSTITUIDO CON ALQUILO, ALCOXI, CARBOXI, ENTRE OTROS; R5A, R5B, R5C, R5D, R5E Y R5F SON H, ALCOXI, ALQUILO, ALCOXICARBONILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(4,6-DIMETIL-2-PIRIDIL)-L-VALIL-(4R)-N-((1R,2S)-1-((CICLOPROPILSULFONIL)CARBAMOIL)-2-VINILCICLOPROPIL)-4-((6-METOXI-1-ISOQUINOLINIL)OXI)-L-PROLINAMIDA, N-(4,6-DIMETIL-2-PIRIDIL)-D-VALIL-(4R)-N-((1R,2S)-1-((CICLOPROPILSULFONIL)CARBAMOIL)-2-VINILCICLOPROPIL)-4-((6-METOXI-1-ISOQUINOLINIL)OXI)-L-PROLINAMIDA, N-(5-(TRIFLUOROMETIL)-2-PIRIDIL)VALIL-(4R)-N-((1R,2S)-1-((CICLOPROPILSULFONIL)CARBAMOIL)-2-VINILCICLOPROPIL)-4-((6-METOXI-1-ISOQUINOLINIL)OXI)-L-PROLINAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEASA NS3 CODIFICADA POR EL VIRUS DE LA HEPATITIS C
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86503406P | 2006-11-09 | 2006-11-09 | |
US11/934,840 US7772180B2 (en) | 2006-11-09 | 2007-11-05 | Hepatitis C virus inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081344A1 true PE20081344A1 (es) | 2008-09-18 |
Family
ID=39304590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001545A PE20081344A1 (es) | 2006-11-09 | 2007-11-09 | Inhibidores del virus de la hepatitis c |
Country Status (18)
Country | Link |
---|---|
US (1) | US7772180B2 (es) |
EP (1) | EP2086963B1 (es) |
JP (1) | JP2010509359A (es) |
KR (1) | KR20090082467A (es) |
CN (1) | CN101541784B (es) |
AR (1) | AR063653A1 (es) |
AU (1) | AU2007319435A1 (es) |
BR (1) | BRPI0718625A2 (es) |
CA (1) | CA2669310A1 (es) |
CL (1) | CL2007003250A1 (es) |
EA (1) | EA200900676A1 (es) |
IL (1) | IL198248A0 (es) |
MX (1) | MX2009004888A (es) |
NO (1) | NO20091591L (es) |
NZ (1) | NZ576817A (es) |
PE (1) | PE20081344A1 (es) |
TW (1) | TW200826938A (es) |
WO (1) | WO2008060927A2 (es) |
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-
2007
- 2007-11-05 US US11/934,840 patent/US7772180B2/en active Active
- 2007-11-08 NZ NZ576817A patent/NZ576817A/en not_active IP Right Cessation
- 2007-11-08 EP EP07864081.0A patent/EP2086963B1/en active Active
- 2007-11-08 CN CN2007800416231A patent/CN101541784B/zh not_active Expired - Fee Related
- 2007-11-08 BR BRPI0718625-8A patent/BRPI0718625A2/pt not_active IP Right Cessation
- 2007-11-08 WO PCT/US2007/084012 patent/WO2008060927A2/en active Application Filing
- 2007-11-08 CA CA002669310A patent/CA2669310A1/en not_active Abandoned
- 2007-11-08 MX MX2009004888A patent/MX2009004888A/es active IP Right Grant
- 2007-11-08 AU AU2007319435A patent/AU2007319435A1/en not_active Abandoned
- 2007-11-08 EA EA200900676A patent/EA200900676A1/ru unknown
- 2007-11-08 JP JP2009536467A patent/JP2010509359A/ja active Pending
- 2007-11-08 KR KR1020097011785A patent/KR20090082467A/ko not_active Application Discontinuation
- 2007-11-09 PE PE2007001545A patent/PE20081344A1/es not_active Application Discontinuation
- 2007-11-09 CL CL200703250A patent/CL2007003250A1/es unknown
- 2007-11-09 TW TW096142550A patent/TW200826938A/zh unknown
- 2007-11-09 AR ARP070105019A patent/AR063653A1/es active Pending
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AU2007319435A1 (en) | 2008-05-22 |
MX2009004888A (es) | 2009-05-19 |
CN101541784B (zh) | 2013-04-24 |
JP2010509359A (ja) | 2010-03-25 |
AR063653A1 (es) | 2009-02-04 |
NZ576817A (en) | 2011-08-26 |
WO2008060927A3 (en) | 2008-07-03 |
CN101541784A (zh) | 2009-09-23 |
EP2086963A2 (en) | 2009-08-12 |
KR20090082467A (ko) | 2009-07-30 |
WO2008060927A2 (en) | 2008-05-22 |
TW200826938A (en) | 2008-07-01 |
US7772180B2 (en) | 2010-08-10 |
NO20091591L (no) | 2009-07-28 |
EP2086963B1 (en) | 2015-09-16 |
EA200900676A1 (ru) | 2010-02-26 |
IL198248A0 (en) | 2009-12-24 |
CA2669310A1 (en) | 2008-05-22 |
CL2007003250A1 (es) | 2008-05-23 |
BRPI0718625A2 (pt) | 2014-04-01 |
US20080119461A1 (en) | 2008-05-22 |
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