PE20071223A1 - Procedimiento de preparacion de derivados de acil-amino-alquilen-amida - Google Patents
Procedimiento de preparacion de derivados de acil-amino-alquilen-amidaInfo
- Publication number
- PE20071223A1 PE20071223A1 PE2007000444A PE2007000444A PE20071223A1 PE 20071223 A1 PE20071223 A1 PE 20071223A1 PE 2007000444 A PE2007000444 A PE 2007000444A PE 2007000444 A PE2007000444 A PE 2007000444A PE 20071223 A1 PE20071223 A1 PE 20071223A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- alkyl
- procedure
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE ACIL-AMINO-ALQUILEN-AMIDA DE FORMULA (I) DONDE R ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C7), TRIFLUOROMETILO, OH O ALCOXILO(C1-C7); R1 ES H O ALQUILO(C1-C7); R2 ES H, ALQUILO(C1-C7) O FENILO; R3 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C7), TRIFLUOROMETILO, OH O ALCOXILO(C1-C7), NAFTILO, ENTRE OTROS; R5 ES CICLOALQUILO(C3-C8), D-AZA-CICLOHEPTAN-2-ON-3-ILO, ENTRE OTROS; EN DONDE DICHO PROCEDIMIENTO COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA BASE TAL COMO ETOXIDO DE SODIO EN PRESENCIA DE UN SOLVENTE ORGANICO TAL COMO TETRAHIDROFURANO PARA FORMAR UN COMPUESTO DE FORMULA (III), DONDE T ES UN GRUPO PROTECTOR TAL COMO TERBUTOXI-CARBONILO; B) HACER REACCIONAR EL COMPUESTO DE FORMULA (III) CON UN COMPUESTO DE FORMULA (IV) EN PRESENCIA DE UNA BASE TAL COMO TRIETIL-AMINA Y UN SOLVENTE ORGANICO TAL COMO TERBUTIL-METIL-ETER PARA FORMAR UN COMPUESTO DE FORMULA (I), DONDE X ES HALOGENO; Y C) FORMAR UN SOLVATO O HIDRATO EN FORMA OPCIONAL. DICHO COMPUESTO DE FORMULA (I) ES EL HEMI-HIDRATO DE N-[(R)-EPSILON-CAPROLACTAMA-3-IL]-AMIDA DEL ACIDO (4R)-4-[N'-METIL-N'-(3,5-BIS-TRIFLUORO-METIL-BENZOIL)-AMINO]-4-(3,4-DICLORO-BENCIL)-BUT-2-ENOICO SIENDO UTIL EN EL TRATAMIENTO DEL SINDROME DEL INTESTINO IRRITABLE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
| GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071223A1 true PE20071223A1 (es) | 2008-01-22 |
Family
ID=38324102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000444A PE20071223A1 (es) | 2006-04-13 | 2007-04-11 | Procedimiento de preparacion de derivados de acil-amino-alquilen-amida |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8008479B2 (es) |
| EP (1) | EP2010498B1 (es) |
| JP (1) | JP5208917B2 (es) |
| KR (1) | KR20080108291A (es) |
| AR (1) | AR060506A1 (es) |
| AT (1) | ATE486853T1 (es) |
| AU (1) | AU2007237482B2 (es) |
| CA (1) | CA2645362C (es) |
| CL (1) | CL2007001040A1 (es) |
| CY (1) | CY1111294T1 (es) |
| DE (1) | DE602007010269D1 (es) |
| DK (1) | DK2010498T3 (es) |
| EC (1) | ECSP088820A (es) |
| GT (1) | GT200800209A (es) |
| HK (1) | HK1125640A1 (es) |
| HR (1) | HRP20110045T1 (es) |
| JO (1) | JO2630B1 (es) |
| MA (1) | MA30394B1 (es) |
| MX (1) | MX2008013117A (es) |
| MY (1) | MY145069A (es) |
| NO (1) | NO20084783L (es) |
| NZ (1) | NZ571142A (es) |
| PE (1) | PE20071223A1 (es) |
| PL (1) | PL2010498T3 (es) |
| PT (1) | PT2010498E (es) |
| RU (1) | RU2433122C2 (es) |
| SI (1) | SI2010498T1 (es) |
| TW (1) | TW200815358A (es) |
| WO (1) | WO2007118651A1 (es) |
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| WO2017143038A1 (en) | 2016-02-16 | 2017-08-24 | Concert Pharmaceuticals, Inc. | Deuterated gft-505 |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ288345B6 (en) * | 1995-02-22 | 2001-05-16 | Novartis Ag | Arylacylaminoethanes, process of their preparation and pharmaceutical preparation in which they are comprised |
| MY132550A (en) | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB0010958D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en active Active
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en active Application Filing
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Application Discontinuation
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2009
- 2009-05-15 HK HK09104457.9A patent/HK1125640A1/xx not_active IP Right Cessation
-
2011
- 2011-01-21 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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