PE20121050A1 - Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog - Google Patents

Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog

Info

Publication number
PE20121050A1
PE20121050A1 PE2011002119A PE2011002119A PE20121050A1 PE 20121050 A1 PE20121050 A1 PE 20121050A1 PE 2011002119 A PE2011002119 A PE 2011002119A PE 2011002119 A PE2011002119 A PE 2011002119A PE 20121050 A1 PE20121050 A1 PE 20121050A1
Authority
PE
Peru
Prior art keywords
ftalazin
hedgehog
piperidin
trajectory
pyrazole
Prior art date
Application number
PE2011002119A
Other languages
English (en)
Inventor
Philip Arthur Hipskind
Bharvin Kumar Patel
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20121050A1 publication Critical patent/PE20121050A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES H O METILO; R2 ES H O METILO; R3, R4, R5, R6 O R7 SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, TRIFLUOROMETILO, METILSULFONIO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-FLUORO-N-METIL-N-(1-(4-(1-METIL-1H-PIRAZOL-5-IL)FTALAZIN-1-IL)PIPERIDIN-4-IL)-2-(TRIFLUOROMETIL)BENZAMIDA; ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN ANTAGONISTA DE LA TRAYECTORIA DE HEDGEHOG UTIL EN EL TRATAMIENTO DEL CANCER
PE2011002119A 2009-06-19 2010-06-15 Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog PE20121050A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21862809P 2009-06-19 2009-06-19

Publications (1)

Publication Number Publication Date
PE20121050A1 true PE20121050A1 (es) 2012-08-09

Family

ID=42332981

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011002119A PE20121050A1 (es) 2009-06-19 2010-06-15 Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog

Country Status (36)

Country Link
US (2) US8273742B2 (es)
EP (1) EP2443104B1 (es)
JP (1) JP5596139B2 (es)
KR (1) KR101389165B1 (es)
CN (1) CN102459233B (es)
AR (1) AR077014A1 (es)
AU (1) AU2010260244B2 (es)
BR (1) BRPI1011601A2 (es)
CA (1) CA2764542C (es)
CL (1) CL2011003147A1 (es)
CO (1) CO6480932A2 (es)
CR (1) CR20110658A (es)
DK (1) DK2443104T3 (es)
DO (1) DOP2011000386A (es)
EA (1) EA019059B1 (es)
EC (1) ECSP11011541A (es)
ES (1) ES2409054T3 (es)
HK (1) HK1164872A1 (es)
HN (1) HN2011003139A (es)
HR (1) HRP20130408T1 (es)
IL (1) IL216599A (es)
JO (1) JO2931B1 (es)
MA (1) MA33363B1 (es)
MX (1) MX2011014029A (es)
MY (1) MY156667A (es)
NZ (1) NZ596882A (es)
PE (1) PE20121050A1 (es)
PL (1) PL2443104T3 (es)
PT (1) PT2443104E (es)
SG (1) SG177289A1 (es)
SI (1) SI2443104T1 (es)
TN (1) TN2011000627A1 (es)
TW (1) TWI385165B (es)
UA (1) UA106755C2 (es)
WO (1) WO2010147917A1 (es)
ZA (1) ZA201108587B (es)

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EA017386B1 (ru) 2008-11-17 2012-12-28 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
AU2009314288B2 (en) * 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9464079B2 (en) 2011-03-23 2016-10-11 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
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WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105017140B (zh) * 2014-04-28 2017-12-29 复旦大学 邻氨基苯甲酰胺化合物及其制备方法和用途
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
CA2987067A1 (en) * 2015-06-05 2016-12-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
EA201892075A1 (ru) 2016-03-15 2019-04-30 Оризон Дженомикс, С.А. Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
CN106279114B (zh) * 2016-08-04 2019-01-29 东南大学 一种Taladegib的合成方法
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN106831718B (zh) * 2016-12-30 2019-05-07 上海科技大学 平滑受体配体及其应用
JP7323457B2 (ja) 2017-05-18 2023-08-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 肥満細胞疾患の処置のための方法及び医薬組成物
JP7327855B2 (ja) 2020-06-26 2023-08-16 ラクオリア創薬株式会社 レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬
EP4229828A1 (en) * 2020-10-13 2023-08-23 Endeavor Biomedicines, Inc. Methods of treating fibrosis

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EA017386B1 (ru) 2008-11-17 2012-12-28 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
AU2009314288B2 (en) 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
AU2010260244A1 (en) 2012-01-19
EP2443104A1 (en) 2012-04-25
MA33363B1 (fr) 2012-06-01
MX2011014029A (es) 2012-02-21
US9000023B2 (en) 2015-04-07
CA2764542C (en) 2013-09-10
BRPI1011601A2 (pt) 2016-03-22
HRP20130408T1 (en) 2013-06-30
JO2931B1 (en) 2015-09-15
EA201270049A1 (ru) 2012-05-30
CN102459233B (zh) 2014-07-02
US20100324048A1 (en) 2010-12-23
CL2011003147A1 (es) 2012-07-20
EA019059B1 (ru) 2013-12-30
KR20120024783A (ko) 2012-03-14
ZA201108587B (en) 2013-05-29
TW201113268A (en) 2011-04-16
NZ596882A (en) 2013-08-30
IL216599A0 (en) 2012-03-01
SG177289A1 (en) 2012-02-28
PT2443104E (pt) 2013-05-07
HK1164872A1 (en) 2012-09-28
ES2409054T3 (es) 2013-06-24
TWI385165B (zh) 2013-02-11
JP2012530705A (ja) 2012-12-06
DK2443104T3 (da) 2013-05-06
UA106755C2 (uk) 2014-10-10
AU2010260244B2 (en) 2013-09-05
SI2443104T1 (sl) 2013-07-31
PL2443104T3 (pl) 2013-08-30
JP5596139B2 (ja) 2014-09-24
ECSP11011541A (es) 2012-01-31
US8273742B2 (en) 2012-09-25
TN2011000627A1 (en) 2013-05-24
AR077014A1 (es) 2011-07-27
CO6480932A2 (es) 2012-07-16
EP2443104B1 (en) 2013-04-17
US20120316174A1 (en) 2012-12-13
DOP2011000386A (es) 2012-02-29
HN2011003139A (es) 2013-07-29
MY156667A (en) 2016-03-15
KR101389165B1 (ko) 2014-04-24
CR20110658A (es) 2012-02-20
WO2010147917A1 (en) 2010-12-23
CA2764542A1 (en) 2010-12-23
CN102459233A (zh) 2012-05-16
IL216599A (en) 2015-09-24

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