PE20160846A1 - Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c - Google Patents

Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c

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Publication number
PE20160846A1
PE20160846A1 PE2016000840A PE2016000840A PE20160846A1 PE 20160846 A1 PE20160846 A1 PE 20160846A1 PE 2016000840 A PE2016000840 A PE 2016000840A PE 2016000840 A PE2016000840 A PE 2016000840A PE 20160846 A1 PE20160846 A1 PE 20160846A1
Authority
PE
Peru
Prior art keywords
antagonists
alpha
adenoreceptors
piperidinyltetrahydroquinolines
substituted
Prior art date
Application number
PE2016000840A
Other languages
English (en)
Inventor
Eva Maria Becker-Pelster
Philipp Buchgraber
Anja Buchmuller
Karen Engel
Volker Geiss
Andreas Goller
Frank Wunder
Raimund Kast
Andreas Knorr
Dieter Lang
Gorden Redlich
Carsten Schmeck
Hanna Tinel
Herbert Himmel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of PE20160846A1 publication Critical patent/PE20160846A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

SE REFIERE A DERIVADOS DE PIPERIDINILTETRAHIDROQUINOLINAS SUSTITUIDAS DE FORMULA (I) DONDE R1, R2, R3 Y R4 SON TAL COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: [4-(3,4-DIHIDROISOQUINOLIN-2(1H)-IL)PIPERIDIN-1-IL][2-(2-OXA-6-AZAESPIRO[3.3]HEPT-6-IL)PIRIMIDIN-5-IL]METANONA; [4-(7-FLUORO-3,4-DIHIDROISOQUINOLIN-2(1H)-IL)PIPERIDIN-1-IL][2-(2-OXA-6-AZAESPIRO[3.3]HEPT-6-IL)PIRIMIDIN-5-IL]METANONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR ADRENERGICO ALFA-2C SIENDO UTILES PARA EL TRATAMIENTO DE MICROANGIOPATIAS DIABETICAS, TRASTORNOS TROMBOEMBOLICOS
PE2016000840A 2013-12-19 2014-12-16 Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c PE20160846A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198385 2013-12-19
EP14192877 2014-11-12

Publications (1)

Publication Number Publication Date
PE20160846A1 true PE20160846A1 (es) 2016-09-23

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US (3) US9944621B2 (es)
EP (2) EP3329920A3 (es)
JP (2) JP6487922B2 (es)
KR (1) KR20160098425A (es)
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AP (1) AP2016009276A0 (es)
AU (2) AU2014364732B2 (es)
BR (1) BR112016014008A2 (es)
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CR (1) CR20160276A (es)
CU (1) CU24390B1 (es)
CY (1) CY1120701T1 (es)
DK (1) DK3083592T3 (es)
DO (1) DOP2016000149A (es)
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HU (1) HUE039942T2 (es)
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JO (2) JOP20200052A1 (es)
LT (1) LT3083592T (es)
MX (1) MX365289B (es)
MY (1) MY177393A (es)
NI (1) NI201600084A (es)
NZ (1) NZ758272A (es)
PE (1) PE20160846A1 (es)
PH (1) PH12016501190A1 (es)
PL (1) PL3083592T3 (es)
PT (1) PT3083592T (es)
RS (1) RS57835B1 (es)
SG (1) SG11201604978QA (es)
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UA (1) UA120702C2 (es)
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JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
US20190008867A1 (en) 2015-11-13 2019-01-10 Ph Pharma Co., Ltd. 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
WO2018197333A1 (en) 2017-04-27 2018-11-01 Bayer Aktiengesellschaft Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
CN110917195A (zh) * 2018-08-20 2020-03-27 山西惠尔健生物科技有限公司 肌松剂阿库氯铵（Alcuronium chloride）可作为抗心律失常药物
BR112021007830A2 (pt) * 2018-11-20 2021-08-03 Bayer Aktiengesellschaft antagonistas do adrenoceptor-alfa2 do subtipo c (al-fa-2c) para o tratamento da apneia do sono
WO2020165031A1 (de) 2019-02-15 2020-08-20 Bayer Aktiengesellschaft Substituierte isochinolin-piperidinylmethanon-derivate
WO2020182018A1 (zh) * 2019-03-12 2020-09-17 四川科伦博泰生物医药股份有限公司 氮杂环化合物、其制备方法及用途
CN114644635B (zh) * 2020-12-21 2023-02-03 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用

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