JO3649B1 - بيبريدينيل تترا هيدرو كوينولينات مستبدلة - Google Patents

بيبريدينيل تترا هيدرو كوينولينات مستبدلة

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Publication number
JO3649B1
JO3649B1 JOP/2014/0371A JOP20140371A JO3649B1 JO 3649 B1 JO3649 B1 JO 3649B1 JO P20140371 A JOP20140371 A JO P20140371A JO 3649 B1 JO3649 B1 JO 3649B1
Authority
JO
Jordan
Prior art keywords
diabetic
prevention
treatment
peripheral
disorders
Prior art date
Application number
JOP/2014/0371A
Other languages
English (en)
Inventor
Volker Geiss Dr
Andreas Knorr Dr
Raimund Kast Dr
Gorden Redlich Dr
Eva Maria Becker-Pelster Dr
Anja Buchmüller Dr
Frank Wunder Dr
Karen Engel Dr
Carsten Schmeck Dr
Herbert Himmel Dr
Philipp Buchgraber Dr
Hanna Tinel Dr
Andreas Gӧller Dr
Dieter Lang Dr
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of JO3649B1 publication Critical patent/JO3649B1/ar

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<strong><span dir="RTL">يتعلق الطلب الحالي مع </span>piperidinyltetrahydroquinolines<span dir="RTL"> مستبدلة جديدة، بعمليات لتحضيرها، باستخدامها في طريقة للمعالجة و/أو لمنع الأمراض وباستخدامها لتحضير أدوية للمعالجة و/أو لمنع الأمراض، بالتحديد لمعالجة و/أو لمنع اعتلال الشعيرات الدموية بسبب مرض السكر، قرحات على الأطراف بسبب مرض السكر، بالتحديد لتعزيز التئام الجروح لقرحات القدم السكري، فشل القلب بسبب مرض السكر، اضطرابات الأوعية الدقيقة التاجية بالقلب بسبب مرض السكر، اضطرابات الأوعية الطرفية والقلبية، اضطرابات تجلطية انسدادية ونقص الإمداد الدموي، اضطرابات الدورة الدموية الطرفية، ظاهرة </span>Raynaud<span dir="RTL">، عرض </span>CREST<span dir="RTL">، اضطرابات الدورة الدموية الصغرى، عرج متقطع، واعتلال الأعصاب الطرفية واللاإرادية.</span></strong>
JOP/2014/0371A 2013-12-19 2014-12-18 بيبريدينيل تترا هيدرو كوينولينات مستبدلة JO3649B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198385 2013-12-19
EP14192877 2014-11-12

Publications (1)

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JO3649B1 true JO3649B1 (ar) 2020-08-27

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JOP/2014/0371A JO3649B1 (ar) 2013-12-19 2014-12-18 بيبريدينيل تترا هيدرو كوينولينات مستبدلة

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JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
US20190008867A1 (en) 2015-11-13 2019-01-10 Ph Pharma Co., Ltd. 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
US20200230136A1 (en) 2017-04-27 2020-07-23 Bayer Aktiengesellschaft Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
CN110917195A (zh) * 2018-08-20 2020-03-27 山西惠尔健生物科技有限公司 肌松剂阿库氯铵（Alcuronium chloride）可作为抗心律失常药物
BR112021007830A2 (pt) 2018-11-20 2021-08-03 Bayer Aktiengesellschaft antagonistas do adrenoceptor-alfa2 do subtipo c (al-fa-2c) para o tratamento da apneia do sono
WO2020165031A1 (de) 2019-02-15 2020-08-20 Bayer Aktiengesellschaft Substituierte isochinolin-piperidinylmethanon-derivate
CN113330009B (zh) * 2019-03-12 2024-02-09 四川科伦博泰生物医药股份有限公司 氮杂环化合物、其制备方法及用途
WO2022135335A1 (zh) * 2020-12-21 2022-06-30 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用

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